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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891 Species: Rattus norvegicus RGD Object: Gene Symbol: Il1b Name: interleukin 1 beta

Acc ID: CHEBI:61668 Term: oroxylin A Definition: A dihydroxy- and monomethoxy-flavone in which the hydroxy groups are positioned at C-5 and C-7 and the methoxy group is at C-6. CasRN: 480-11-5 Chemical ID: MESH:C080669

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:10790	6480464	CTD	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]	PMID:22101131