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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:59219
Term: ceruletide
Definition: A decapeptide comprising 5-oxoprolyl, glutamyl, aspartyl, O-sulfotyrosyl, threonyl, glycyl, tryptopyl, methionyl, aspartyl and phenylalaninamide residues in sequence. Found in the skins of certain Australian amphibians, it is an analogue of the gastrointestinal peptide hormone cholecystokinin and stimulates gastric, biliary, and pancreatic secretion. It is used in cases of paralysis of the intestine (paralytic ileus) and as a diagnostic aid in pancreatic malfunction.
Chemical ID: MESH:D002108
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bincreases expressionEXP 6480464CTDCeruletide results in increased expression of IL1B mRNA; Ceruletide results in increased expression of IL1B proteinPMID:14751415 PMID:24234420 PMID:26873426
Il1bincreases secretionEXP 6480464CTDCeruletide results in increased secretion of IL1B proteinPMID:26873426
Il1bmultiple interactionsEXP 6480464CTDDietary Fats promotes the reaction [Ceruletide results in increased expression of IL1B mRNA]; Dietary Fats promotes the reaction [Ceruletide results in increased secretion of IL1B protein]; Quercetin inhibits the reaction [Ceruletide results in increased expression of IL1B mRNA]; Quercetin inhibits the reaction [Dietary Fats promotes the reaction [Ceruletide results in increased expression of IL1B mRNA]]; resveratrol inhibits the reaction [Ceruletide results in increased expression of IL1B protein]PMID:24234420 PMID:26873426
Il1bincreases expressionISOIl1b (Mus musculus)6480464CTDCeruletide results in increased expression of IL1B mRNA; Ceruletide results in increased expression of IL1B proteinPMID:21484880 PMID:33166053
Il1bincreases secretionISOIl1b (Mus musculus)6480464CTDCeruletide results in increased secretion of IL1B proteinPMID:34423886
Il1bmultiple interactionsISOIl1b (Mus musculus)6480464CTDcoumermycin inhibits the reaction [limonin inhibits the reaction [Ceruletide results in increased secretion of IL1B protein]]; isoborneol inhibits the reaction [Ceruletide results in increased expression of IL1B protein]; limonin inhibits the reaction [Ceruletide results in increased secretion of IL1B protein]; Resveratrol inhibits the reaction [Ceruletide results in increased secretion of IL1B protein]PMID:33166053 PMID:34423886
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