RGD Reference Report - Significance of IL-1beta and IL-1 receptor antagonist (IL-1Ra) in bronchoalveolar lavage fluid (BALF) in patients with diffuse panbronchiolitis (DPB). - Rat Genome Database

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Significance of IL-1beta and IL-1 receptor antagonist (IL-1Ra) in bronchoalveolar lavage fluid (BALF) in patients with diffuse panbronchiolitis (DPB).

Authors: Kadota, J  Matsubara, Y  Ishimatsu, Y  Ashida, M  Abe, K  Shirai, R  Iida, K  Kawakami, K  Taniguchi, H  Fujii, T  Kaseda, M  Kawamoto, S  Kohno, S 
Citation: Kadota J, etal., Clin Exp Immunol. 1996 Mar;103(3):461-6.
RGD ID: 4143192
Pubmed: PMID:8608647   (View Abstract at PubMed)
PMCID: PMC2200364   (View Article at PubMed Central)

We evaluated the effect of erythromycin therapy on pulmonary function tests and the airway inflammatory response of patients with DPB. The number of neutrophils in BALF obtained from DPB patients was significantly higher than that of healthy volunteers. Treatment with erythromycin (600 mg/day for 12.9+/-9.5 months (mean +/- s.d.)) significantly reduced the total number of cells and neutrophils in the airway, and significantly improved pulmonary function tests. The levels of IL-1beta and IL-8 were significantly higher in DPB compared with healthy volunteers (P<0.05, P<0.05, respectively). IL-1Ra in patients is considered to have a weak inhibitory activity for IL-1beta, with approximately five-fold concentration of IL-1beta compared with that in healthy volunteers (approx. nine-fold concentration of IL-1beta). Erythromycin therapy significantly reduced these cytokines to levels comparable to those of healthy volunteers, and produced a trend toward reduction in the level of IL-1Ra in BALF. The level of IL-1beta correlated significantly with the concentration of neutrophils in BALF (r=0.72, P<0.01), as well as with the level of IL-1Ra (r=0.688, P<0.05) and IL-8 (r=0.653, P<0.05). A nearly significant or significant correlation was observed between the concentration of neutrophils and levels of IL-1Ra or IL-8 in BALF (r=0.526, P=0.053 or r=0.776, P<0.01, respectively). There was also a significant relationship between FEV(1) and the concentration of neutrophils in BALF (r=0.524, P<0.05). Our results suggest that the relative amounts of IL-1beta and IL-1Ra or IL-8 may contribute, at least in part, to the neutrophil-mediated chronic airway inflammation in patients with chronic airway disease, and long-term erythromycin therapy may down-regulate the vigorous cycle between the cytokine network and neutrophil accumulation, with resultant reduction of neutrophil-mediated inflammatory response.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
bronchiolitis  IEP 4143192; 4143192protein:increased expression:lungRGD 
bronchiolitis  ISOIL1B (Homo sapiens)4143192; 4143192protein:increased expression:lungRGD 
bronchiolitis  ISOIL1RN (Homo sapiens)4143192; 4143192protein:increased expression:lungRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il1b  (interleukin 1 beta)
Il1rn  (interleukin 1 receptor antagonist)

Genes (Mus musculus)
Il1b  (interleukin 1 beta)
Il1rn  (interleukin 1 receptor antagonist)

Genes (Homo sapiens)
IL1B  (interleukin 1 beta)
IL1RN  (interleukin 1 receptor antagonist)


Additional Information