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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891 Species: Rattus norvegicus RGD Object: Gene Symbol: Il1b Name: interleukin 1 beta

Acc ID: CHEBI:15367 Term: all-trans-retinoic acid Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry. CasRN: 302-79-4 Chemical ID: MESH:D014212

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:730981	6480464	CTD	Tretinoin metabolite results in increased expression of IL1B mRNA	PMID:15982314
decreases expression	ISO	RGD:730981	6480464	CTD	Tretinoin results in decreased expression of IL1B protein	PMID:17118196
multiple interactions	ISO	RGD:730981	6480464	CTD	Tretinoin results in increased expression of and results in increased secretion of IL1B protein	PMID:16804330
increases expression	ISO	RGD:730981	6480464	CTD	Tretinoin results in increased expression of IL1B mRNA	PMID:14646600 PMID:16804330 PMID:15982314
multiple interactions	EXP		6480464	CTD	IL1B protein promotes the reaction [Tretinoin results in increased expression of ALPL mRNA] IL1B protein promotes the reaction [Tretinoin results in increased expression of and results in increased activity of ALPL protein] IL1B protein promotes the reaction [Tretinoin results in increased expression of RARB protein] IL1B protein promotes the reaction [Tretinoin results in increased expression of RXRB protein]	PMID:11171635
multiple interactions	EXP		6480464	CTD	IL1B protein promotes the reaction [Tretinoin affects the localization of RXRB protein] IL1B protein promotes the reaction [Tretinoin affects the localization of RARA protein]	PMID:17078027
decreases expression	EXP		6480464	CTD	Tretinoin results in decreased expression of IL1B mRNA	PMID:12969142
increases expression	ISO	RGD:730981	6480464	CTD	Tretinoin results in increased expression of IL1B mRNA	PMID:16804330 PMID:15982314 PMID:14646600
increases expression	ISO	RGD:730981	6480464	CTD	Tretinoin results in increased expression of IL1B mRNA	PMID:14646600 PMID:15982314 PMID:16804330 PMID:15498508
increases expression	ISO	RGD:730981	6480464	CTD	Tretinoin results in increased expression of IL1B mRNA	PMID:15498508 PMID:15982314 PMID:16804330 PMID:14646600
multiple interactions	EXP		6480464	CTD	Tretinoin inhibits the reaction [Ursodeoxycholic Acid results in decreased expression of IL1B mRNA] Ursodeoxycholic Acid inhibits the reaction [Tretinoin results in decreased expression of IL1B mRNA]	PMID:21274875
decreases expression	EXP		6480464	CTD	Tretinoin results in decreased expression of IL1B mRNA	PMID:12969142 PMID:21274875
increases expression	ISO	RGD:730981	6480464	CTD	Tretinoin results in increased expression of IL1B mRNA	PMID:16804330 PMID:15498508 PMID:14646600 PMID:15982314
decreases expression	EXP		6480464	CTD	Tretinoin results in decreased expression of IL1B mRNA	PMID:21274875 PMID:12969142
multiple interactions	EXP		6480464	CTD	Tretinoin inhibits the reaction [Mercuric Chloride results in increased expression of IL1B mRNA]	PMID:17250768
increases expression	ISO	RGD:730981	6480464	CTD	Tretinoin results in increased expression of IL1B mRNA	PMID:16804330 PMID:15982314 PMID:15498508 PMID:14646600
increases expression	ISO	RGD:730981	6480464	CTD	Tretinoin results in increased expression of IL1B mRNA	PMID:14646600 PMID:15498508 PMID:15982314 PMID:16804330