GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:49662
Term: indomethacin
Definition: An indole-3-acetic acid that has formula C19H16ClNO4.
CasRN: 53-86-1
Chemical ID: MESH:D007213
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7309816480464CTDIndomethacin inhibits the reaction [IL1B protein results in decreased expression of COL1A1 mRNA]

PMID:8971655
multiple interactionsISORGD:7309816480464CTDIndomethacin inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]

PMID:15705740
multiple interactionsISORGD:7309816480464CTDIndomethacin inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]

PMID:12512699
multiple interactionsISORGD:7309816480464CTDIndomethacin inhibits the reaction [IL1B results in increased activity of EDNRB]

PMID:12126971
multiple interactionsISORGD:7309816480464CTDIndomethacin inhibits the reaction [IL1B results in increased chemical synthesis of Dinoprostone]

Indomethacin inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]

PMID:16529823
multiple interactionsISORGD:7309816480464CTDIndomethacin promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]

PMID:10772282
multiple interactionsISORGD:7309816480464CTDIndomethacin inhibits the reaction [[Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein] results in increased abundance of Dinoprostone]

Indomethacin inhibits the reaction [[Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein] results in increased abundance of Prostaglandin D2]

PMID:12743569
decreases secretionISORGD:7309816480464CTDIndomethacin results in decreased secretion of IL1B protein

PMID:10393680
PMID:10388637
increases secretionISORGD:7309816480464CTDIndomethacin results in increased secretion of IL1B protein

PMID:10772282
multiple interactionsISORGD:107906480464CTD[Indomethacin co-treated with Medroxyprogesterone Acetate] results in decreased secretion of IL1B protein

PMID:16537180
multiple interactionsISORGD:107906480464CTDIndomethacin inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]

Indomethacin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]

PMID:18799549
increases expressionISORGD:107906480464CTDIndomethacin results in increased expression of IL1B protein

PMID:17329845
multiple interactionsISORGD:107906480464CTDoren gedoku to inhibits the reaction [Indomethacin results in increased expression of IL1B protein]

PMID:17329845
multiple interactionsEXP 6480464CTDIndomethacin inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]

PMID:11286988
multiple interactionsEXP 6480464CTDIndomethacin inhibits the reaction [IL1B protein results in increased secretion of CRH protein]

PMID:11852909
increases expressionEXP 6480464CTDIndomethacin results in increased expression of IL1B protein

PMID:16133968
increases expressionEXP 6480464CTDIndomethacin results in increased expression of IL1B mRNA

PMID:11950807
multiple interactionsEXP 6480464CTDTheophylline inhibits the reaction [Indomethacin results in increased expression of IL1B protein]

Pentoxifylline inhibits the reaction [Indomethacin results in increased expression of IL1B protein]

TNF protein affects the reaction [Indomethacin results in increased expression of IL1B protein]

PMID:16133968
increases secretionEXP 6480464CTDIndomethacin results in increased secretion of IL1B protein

PMID:21451212
decreases secretionISORGD:7309816480464CTDIndomethacin results in decreased secretion of IL1B protein

PMID:10388637
PMID:10393680
multiple interactionsISORGD:7309816480464CTDIndomethacin inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]

PMID:12517972
PMID:15705740
multiple interactionsISORGD:7309816480464CTDIndomethacin promotes the reaction [IL1B protein results in increased expression of PTGS2 mRNA]

PMID:12517972
multiple interactionsISORGD:7309816480464CTDIndomethacin inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]

PMID:12512699
PMID:12517972
increases expressionISORGD:7309816480464CTDIndomethacin results in increased expression of [IL1B protein results in increased expression of PTGS2 protein]

PMID:12517972
multiple interactionsEXP 6480464CTDIndomethacin inhibits the reaction [Formaldehyde results in increased expression of IL1B protein]

PMID:21983654
multiple interactionsEXP 6480464CTDIndomethacin promotes the reaction [Acetic Acid results in increased expression of IL1B protein]

PMID:11376495
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