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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891 Species: Rattus norvegicus RGD Object: Gene Symbol: Il1b Name: interleukin 1 beta

Acc ID: CHEBI:17489 Term: 3',5'-cyclic AMP Definition: 3',5'-cyclic purine nucleotide having having adenine as the nucleobase. CasRN: 60-92-4 Chemical ID: MESH:D000242

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:730981	6480464	CTD	Ibuprofen inhibits the reaction [IL1B protein results in increased abundance of Cyclic AMP]	PMID:17709599
increases abundance	ISO	RGD:730981	6480464	CTD	IL1B protein results in increased abundance of Cyclic AMP	PMID:17709599
multiple interactions	ISO	RGD:730981	6480464	CTD	Dipyridamole promotes the reaction [IL1B protein results in increased abundance of Cyclic AMP] 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone promotes the reaction [IL1B protein results in increased abundance of Cyclic AMP] KT 5720 inhibits the reaction [Dipyridamole promotes the reaction [IL1B protein results in increased abundance of Cyclic AMP]] Rolipram promotes the reaction [IL1B protein results in increased abundance of Cyclic AMP] KT 5823 inhibits the reaction [Dipyridamole promotes the reaction [IL1B protein results in increased abundance of Cyclic AMP]]	PMID:8904084
increases abundance	ISO	RGD:730981	6480464	CTD	IL1B protein results in increased abundance of Cyclic AMP	PMID:8904084 PMID:17709599
increases abundance	ISO	RGD:730981	6480464	CTD	IL1B protein results in increased abundance of Cyclic AMP	PMID:17709599 PMID:8904084
multiple interactions	ISO	RGD:10790	6480464	CTD	Cyclic AMP promotes the reaction [IL1B protein results in increased expression of IL1RN mRNA] Cyclic AMP inhibits the reaction [IL1B protein results in increased expression of HP mRNA] Cyclic AMP inhibits the reaction [IL1B protein results in increased expression of CRP mRNA]	PMID:22117073