Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bincreases expressionEXP 6480464CTDCadmium Chloride results in increased expression of IL1B mRNA; Cadmium Chloride results in increased expression of IL1B proteinPMID:24954678 PMID:25446329 PMID:32392679 PMID:36493885
Il1bmultiple interactionsEXP 6480464CTD[[nickel chloride results in increased abundance of Nickel] co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] results in increased expression of IL1B protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL1B mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL1B protein; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IL1B mRNA]; cordycepin inhibits the reaction [Cadmium Chloride results in increased expression of IL1B protein]; dendropanoxide inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL1B protein]; Fatty Acids, Omega-3 inhibits the reaction [[[nickel chloride results in increased abundance of Nickel] co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] results in increased expression of IL1B protein]; galangin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL1B protein]; protocatechuic acid inhibits the reaction [Cadmium Chloride results in increased expression of IL1B mRNA]; protocatechuic acid inhibits the reaction [Cadmium Chloride results in increased expression of IL1B protein]; Silymarin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL1B protein]; Triiodothyronine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL1B protein]PMID:31639282 PMID:32392679 PMID:34510229 PMID:35384154 PMID:36493885 PMID:36718047 PMID:36731150 PMID:36868496
Il1bdecreases expressionISOIl1b (Mus musculus)6480464CTDCadmium Chloride results in decreased expression of IL1B mRNAPMID:23503628 PMID:28666365
Il1bdecreases expressionISOIL1B (Homo sapiens)6480464CTDCadmium Chloride results in decreased expression of IL1B mRNAPMID:26472689
Il1bincreases cleavageISOIl1b (Mus musculus)6480464CTDCadmium Chloride results in increased cleavage of IL1B proteinPMID:30796460
Il1bincreases cleavageISOIL1B (Homo sapiens)6480464CTDCadmium Chloride results in increased cleavage of IL1B proteinPMID:30796460 PMID:35650140
Il1bincreases expressionISOIl1b (Mus musculus)6480464CTDCadmium Chloride results in increased expression of IL1B mRNA; Cadmium Chloride results in increased expression of IL1B proteinPMID:22271428 PMID:23948867 PMID:25528414 PMID:26352046 PMID:34743973 PMID:35844137 PMID:35983679 PMID:7536360
Il1bincreases expressionISOIL1B (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of IL1B; Cadmium Chloride results in increased expression of IL1B mRNAPMID:15033544 PMID:21605009 PMID:30796460 PMID:35650140
Il1bincreases secretionISOIL1B (Homo sapiens)6480464CTDCadmium Chloride results in increased secretion of IL1B proteinPMID:26138014 PMID:30796460
Il1bmultiple interactionsISOIl1b (Mus musculus)6480464CTD4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased cleavage of IL1B protein]; 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of IL1B mRNA]; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL1B mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL1B protein; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IL1B mRNA]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IL1B protein]; caffeic acid phenethyl ester inhibits the reaction [Cadmium Chloride results in increased expression of IL1B protein]; fargesin inhibits the reaction [Cadmium Chloride results in increased expression of IL1B protein]; Gefitinib inhibits the reaction [Cadmium Chloride results in increased expression of IL1B mRNA]; Gefitinib inhibits the reaction [Cadmium Chloride results in increased expression of IL1B protein]; lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [Cadmium Chloride results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of IL1B mRNA]PMID:23948867 PMID:30796460 PMID:33359024 PMID:34743973 PMID:35844137 PMID:35983679 PMID:7536360
Il1bmultiple interactionsISOIL1B (Homo sapiens)6480464CTD7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL1B mRNA]; [Cadmium Chloride co-treated with Lipopolysaccharides] results in increased cleavage of IL1B protein; [Cadmium Chloride co-treated with Lipopolysaccharides] results in increased expression of IL1B mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL1B mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL1B protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased secretion of IL1B protein; Acetylcysteine inhibits the reaction [[Cadmium Chloride co-treated with Lipopolysaccharides] results in increased cleavage of IL1B protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL1B mRNA]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL1B protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased secretion of IL1B protein]; Cadmium Chloride inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Cadmium Chloride inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Cadmium Chloride results in increased expression of and results in increased secretion of IL1B protein; MitoTEMPO inhibits the reaction [[Cadmium Chloride co-treated with Lipopolysaccharides] results in increased cleavage of IL1B protein]; NLRP3 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of and results in increased secretion of IL1B protein]; NLRP3 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL1B mRNA]; NLRP3 protein affects the reaction [Cadmium Chloride results in increased cleavage of IL1B protein]; NLRP3 protein affects the reaction [Cadmium Chloride results in increased expression of IL1B mRNA]; NLRP3 protein promotes the reaction [[Cadmium Chloride co-treated with Lipopolysaccharides] results in increased cleavage of IL1B protein]; SIRT1 protein inhibits the reaction [Cadmium Chloride results in increased cleavage of IL1B protein]; STF 083010 inhibits the reaction [Cadmium Chloride results in increased cleavage of IL1B protein]; STF 083010 inhibits the reaction [Cadmium Chloride results in increased expression of IL1B mRNA]; tyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone analog inhibits the reaction [[Cadmium Chloride co-treated with Lipopolysaccharides] results in increased cleavage of IL1B protein]; tyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone analog inhibits the reaction [Cadmium Chloride results in increased cleavage of IL1B protein]; XBP1 protein alternative form inhibits the reaction [SIRT1 protein inhibits the reaction [Cadmium Chloride results in increased cleavage of IL1B protein]]PMID:11076874 PMID:26138014 PMID:26809137 PMID:30572105 PMID:30796460 PMID:34510229 PMID:35301059 PMID:37300869 PMID:9138684
Go Back to source page   Continue to Ontology report