RGD Reference Report - Pro- and Anti-inflammatory Cytokines in Gingival Crevicular Fluid and Serum of Rheumatoid Arthritis and Chronic Periodontitis Patients. - Rat Genome Database

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Pro- and Anti-inflammatory Cytokines in Gingival Crevicular Fluid and Serum of Rheumatoid Arthritis and Chronic Periodontitis Patients.

Authors: Cetinkaya, B  Guzeldemir, E  Ogus, E  Bulut, S 
Citation: Cetinkaya B, etal., J Periodontol. 2012 Mar 13.
RGD ID: 6482656
Pubmed: PMID:22414257   (View Abstract at PubMed)
DOI: DOI:10.1902/jop.2012.110467   (Journal Full-text)

Background: To evaluate pro- and anti-inflammatory cytokine levels in gingival crevicular fluid (GCF) and serum of rheumatoid arthritis (RA) and chronic periodontitis (CP) patients in order to assess whether cytokine profiles are distinguishing RA and CP patients while using healthy patients as background controls. Methods: A total of 49 patients, 17 RA patients [3 males and 14 females; mean age, 47.82+/-10.74], 16 CP patients [10 males and 6 females; mean age, 44.00+/-7.00], and 16 controls [8 males and 8 females; mean age 28.06+/-6.18]. RA patients were under the supervision of rheumatologists and 15 of the RA patients were being treated with methotrexate-sulfasalazine combined therapy and 2 of the patients were being treated with leflunomid therapy. Periodontal parameters (plaque index, gingival index, probing depth, clinical attachment level) were recorded. Interleukin (IL)-1beta, IL-4, IL-10 and tumor necrosis factor (TNF)-alpha were determined in GCF and IL-1beta and IL-10 in serum by ELISA. Results: There was significant difference found between RA, CP and controls for all periodontal parameters (p<0.05). The total amount and concentration of GCF IL-1 beta, IL-4, IL-10 and TNF-alpha were similar in RA and CP (p>0.05). While the total amount and concentration of serum IL-10 was not significantly different between the groups (p>0.05),serum IL-1beta was significantly lower in the RA group compared to CP and controls and were higher in GCF of the RA group compared to the CP group. Conclusions: Although clinical periodontal disease parameters indicated more severe periodontal disease in CP compare to RA, immunologic evaluation did not reveal consistent results regarding pro- and anti-inflammatory cytokine levels. This might be a result of the use of NSAIDs and rheumatoid agents by RA patients.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
rheumatoid arthritis  IEP 6482656protein:decreased expression:serumRGD 
rheumatoid arthritis  ISOIL1B (Homo sapiens)6482656; 6482656protein:decreased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il1b  (interleukin 1 beta)

Genes (Mus musculus)
Il1b  (interleukin 1 beta)

Genes (Homo sapiens)
IL1B  (interleukin 1 beta)


Additional Information