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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:6716
Term: medroxyprogesterone acetate
Definition: An acetate ester resulting from the formal condensation of the 17alpha-hydroxy group of medroxyprogesterone with the carboxy group of acetic acid. A widely used progestin in menopausal hormone therapy and in progestogen-only birth control.
Chemical ID: MESH:D017258
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bdecreases expressionISOIL1B (Homo sapiens)6480464CTDMedroxyprogesterone Acetate results in decreased expression of IL1B mRNAPMID:20843944
Il1bmultiple interactionsISOIl1b (Mus musculus)6480464CTD[Indomethacin co-treated with Medroxyprogesterone Acetate] results in decreased secretion of IL1B proteinPMID:16537180
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