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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891 Species: Rattus norvegicus RGD Object: Gene Symbol: Il1b Name: interleukin 1 beta

Acc ID: CHEBI:64090 Term: tert-butyl hydroperoxide Definition: An alkyl hydroperoxide in which the alkyl group is tert-butyl. It is widely used in a variety of oxidation processes. CasRN: 75-91-2 Chemical ID: MESH:D020122

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:730981	6480464	CTD	tert-Butylhydroperoxide inhibits the reaction [Acetaminophen inhibits the reaction [Calcimycin promotes the reaction [IL1B protein results in increased activity of PTGS2 protein]]] tert-Butylhydroperoxide inhibits the reaction [Naproxen inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]] tert-Butylhydroperoxide inhibits the reaction [Ibuprofen inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]] tert-Butylhydroperoxide inhibits the reaction [rofecoxib inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]]	PMID:15705740
increases expression	ISO	RGD:730981	6480464	CTD	tert-Butylhydroperoxide results in increased expression of IL1B mRNA	PMID:15336504