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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891 Species: Rattus norvegicus RGD Object: Gene Symbol: Il1b Name: interleukin 1 beta

Acc ID: CHEBI:31401 Term: cilostazol Definition: A lactam that is 3,4-dihydroquinolin-2(1H)-one in which the hydrogen at position 6 is substiuted by a 4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy group. CasRN: 73963-72-1 Chemical ID: MESH:C045645

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:730981	6480464	CTD	cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] HMOX1 mutant form inhibits the reaction [cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]] zinc protoporphyrin inhibits the reaction [cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]	PMID:20131233
decreases expression	ISO	RGD:10790	6480464	CTD	cilostazol results in decreased expression of IL1B protein	PMID:20131233