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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bdecreases expressionEXP 6480464CTDTretinoin results in decreased expression of IL1B mRNAPMID:12969142 PMID:21274875
Il1bmultiple interactionsEXP 6480464CTDIL1B protein promotes the reaction [Tretinoin affects the localization of RARA protein]; IL1B protein promotes the reaction [Tretinoin affects the localization of RXRB protein]; IL1B protein promotes the reaction [Tretinoin results in increased expression of ALPL mRNA]; IL1B protein promotes the reaction [Tretinoin results in increased expression of and results in increased activity of ALPL protein]; IL1B protein promotes the reaction [Tretinoin results in increased expression of RARB protein]; IL1B protein promotes the reaction [Tretinoin results in increased expression of RXRB protein]; Tretinoin inhibits the reaction [Mercuric Chloride results in increased expression of IL1B mRNA]; Tretinoin inhibits the reaction [Ursodeoxycholic Acid results in decreased expression of IL1B mRNA]; Ursodeoxycholic Acid inhibits the reaction [Tretinoin results in decreased expression of IL1B mRNA]PMID:11171635 PMID:17078027 PMID:17250768 PMID:21274875
Il1bdecreases expressionISOIL1B (Homo sapiens)6480464CTDTretinoin results in decreased expression of IL1B proteinPMID:17118196
Il1bincreases expressionISOIL1B (Homo sapiens)6480464CTDTretinoin metabolite results in increased expression of IL1B mRNA; Tretinoin results in increased expression of IL1B mRNAPMID:14646600 PMID:15498508 PMID:15982314 PMID:16804330 PMID:26892147 PMID:33167477
Il1bincreases secretionISOIL1B (Homo sapiens)6480464CTDTretinoin results in increased secretion of IL1B proteinPMID:26892147
Il1bmultiple interactionsISOIL1B (Homo sapiens)6480464CTDArsenic Trioxide promotes the reaction [Tretinoin results in increased expression of IL1B mRNA]; Arsenic Trioxide promotes the reaction [Tretinoin results in increased secretion of IL1B protein]; Tretinoin results in increased expression of and results in increased secretion of IL1B proteinPMID:16804330 PMID:26892147
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