GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Il1b | increases methylation | ISO | IL1B (Homo sapiens) | 6480464 | CTD | Choline results in increased methylation of IL1B gene | PMID:30116142 | Il1b | multiple interactions | ISO | Il1b (Mus musculus) | 6480464 | CTD | 2-acetoxy-5-(2-4-(trifluoromethyl)phenethylamino)benzoic acid inhibits the reaction [[Choline deficiency co-treated with Ethionine] results in increased expression of IL1B protein]; [Choline deficiency co-treated with Ethionine] results in increased expression of IL1B protein; [Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL1B mRNA; [Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL1B protein; [Dietary Fats co-treated with Choline deficiency] results in increased expression of IL1B protein; [Methionine deficiency co-treated with Choline deficiency co-treated with Dietary Fats co-treated with cyanoginosin LR] results in increased expression of IL1B protein; [Methionine deficiency co-treated with Choline deficiency co-treated with Dietary Fats] results in increased expression of IL1B protein; [Methionine deficiency co-treated with Choline deficiency co-treated with RXRA gene mutant form] results in increased expression of IL1B mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with RXRA gene mutant form] results in increased expression of IL1B protein; [Methionine deficiency co-treated with Choline deficiency] results in decreased expression of IL1B protein; [Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1B mRNA; [Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1B protein; alisol A 24-acetate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL1B mRNA]; alisol A 24-acetate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL1B protein]; Atorvastatin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1B mRNA]; Atorvastatin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1B protein]; Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL1B mRNA]; caryophyllene inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1B mRNA]; Chenodeoxycholic Acid affects the reaction [alisol A 24-acetate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL1B mRNA]]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL1B protein]]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL1B mRNA]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL1B protein]; Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1B mRNA]; Emodin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1B protein]; NLRP3 protein affects the reaction [[Methionine deficiency co-treated with Choline deficiency co-treated with Dietary Fats co-treated with cyanoginosin LR] results in increased expression of IL1B protein]; PANX1 gene mutant form inhibits the reaction [[Dietary Fats co-treated with Choline deficiency] results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL1B mRNA]; Resveratrol inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL1B protein]; rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1B mRNA]; rhein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL1B protein]; Smoke affects the reaction [[Methionine deficiency co-treated with Choline deficiency co-treated with Dietary Fats] results in increased expression of IL1B protein] | PMID:18513333 PMID:18952117 PMID:20697377 PMID:22575522 PMID:26498332 PMID:28100771 PMID:28133511 PMID:29097836 PMID:29246445 PMID:29883724 PMID:31678261 PMID:34416350 PMID:37023836 | Il1b | multiple interactions | ISO | IL1B (Homo sapiens) | 6480464 | CTD | [Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in decreased expression of IL1B mRNA; [Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in decreased secretion of IL1B protein; [Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased methylation of IL1B gene | PMID:30116142 | |
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