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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:34718
Term: 1-chloro-2,4-dinitrobenzene
Definition: A C-nitro compound that is chlorobenzene carrying a nitro substituent at each of the 2- and 4-positions.
Chemical ID: MESH:D004137
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1baffects expressionISOIl1b (Mus musculus)6480464CTDDinitrochlorobenzene affects the expression of IL1B mRNAPMID:28219650
Il1baffects expressionISOIL1B (Homo sapiens)6480464CTDDinitrochlorobenzene affects the expression of IL1B mRNAPMID:20146380 PMID:33774146
Il1bincreases expressionISOIl1b (Mus musculus)6480464CTDDinitrochlorobenzene results in increased expression of IL1B mRNA; Dinitrochlorobenzene results in increased expression of IL1B proteinPMID:18652873 PMID:19647056 PMID:21404309
Il1bincreases expressionISOIL1B (Homo sapiens)6480464CTDDinitrochlorobenzene results in increased expression of IL1B mRNA; Dinitrochlorobenzene results in increased expression of IL1B proteinPMID:16314067 PMID:28941582 PMID:30842373 PMID:33715048
Il1bincreases secretionISOIL1B (Homo sapiens)6480464CTDDinitrochlorobenzene results in increased secretion of IL1B proteinPMID:11033066 PMID:33715048
Il1bmultiple interactionsISOIl1b (Mus musculus)6480464CTDLipopolysaccharides promotes the reaction [Dinitrochlorobenzene results in increased expression of IL1B mRNA]; NFE2L2 protein inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL1B mRNA]PMID:16687389 PMID:28219650
Il1bmultiple interactionsISOIL1B (Homo sapiens)6480464CTD[Tetradecanoylphorbol Acetate co-treated with Dinitrochlorobenzene] results in increased expression of and results in increased secretion of IL1B proteinPMID:24964617
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