RGD Reference Report - Interleukin 1 beta gene promoter SNPs are associated with risk of pancreatic cancer. - Rat Genome Database

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Interleukin 1 beta gene promoter SNPs are associated with risk of pancreatic cancer.

Authors: Hamacher, R  Diersch, S  Scheibel, M  Eckel, F  Mayr, M  Rad, R  Bajbouj, M  Schmid, RM  Saur, D  Schneider, G 
Citation: Hamacher R, etal., Cytokine. 2009 May;46(2):182-6. Epub 2009 Feb 28.
RGD ID: 2317215
Pubmed: PMID:19251436   (View Abstract at PubMed)
DOI: DOI:10.1016/j.cyto.2009.01.005   (Journal Full-text)

Epidemiological and experimental data demonstrate, that inflammation contributes significantly to pancreatic carcinogenesis. IL1beta, a pleiotropic cytokine produced by inflammatory cells and tumor cells, promotes cancer progression. Single nucleotide polymorphisms (SNPs) of the IL1beta promoter were found to be associated with an increased risk for certain cancers. In this case-control study we determined IL1beta promoter SNPs in 73 patients with pancreatic cancer and 235 controls. We found that the IL1beta -511CT/-31TC genotype was significantly associated with an increased risk for pancreatic cancer (OR 1.42, p=0.0456). Among pancreatic cancer cases, patients with the -511CT/-31TC genotype had less frequently resectable disease than patients with other IL1beta -511/-31 genotypes (p=0.0323). Furthermore, the IL1beta -511CT/-31TC genotype was more frequent observed in UICC stage IV (p=0.039) and undifferentiated tumors (G3) (p=0.019). In addition, we found that the proinflammatory IL1beta -511CT/-31TC alleles define an IL1beta secretory phenotype in pancreatic cancer cell lines in vitro. These findings provide a first evidence for an association of the IL1beta gene promoter SNPs with risk for pancreatic cancer.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
pancreatic cancer susceptibilityIAGP 2317215DNA:polymorphisms:promoter:-511C>T and -31T>C (human)RGD 
pancreatic cancer susceptibilityISOIL1B (Homo sapiens)2317215; 2317215DNA:polymorphisms:promoter:-511C>T and -31T>C (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il1b  (interleukin 1 beta)

Genes (Mus musculus)
Il1b  (interleukin 1 beta)

Genes (Homo sapiens)
IL1B  (interleukin 1 beta)


Additional Information