GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Il1b | increases expression | EXP | | 6480464 | CTD | Uric Acid results in increased expression of IL1B mRNA; Uric Acid results in increased expression of IL1B protein | PMID:19655406 PMID:33894285 | Il1b | multiple interactions | EXP | | 6480464 | CTD | Colchicine inhibits the reaction [Uric Acid results in increased expression of IL1B protein]; Drugs, Chinese Herbal inhibits the reaction [Uric Acid results in increased expression of IL1B mRNA]; Drugs, Chinese Herbal inhibits the reaction [Uric Acid results in increased expression of IL1B protein]; simiaowan inhibits the reaction [Uric Acid results in increased expression of IL1B protein] | PMID:19655406 PMID:33894285 | Il1b | increases expression | ISO | Il1b (Mus musculus) | 6480464 | CTD | Uric Acid results in increased expression of IL1B mRNA; Uric Acid results in increased expression of IL1B protein | PMID:27542954 | Il1b | increases secretion | ISO | Il1b (Mus musculus) | 6480464 | CTD | Uric Acid results in increased secretion of IL1B protein | PMID:18403674 PMID:21051542 | Il1b | increases secretion | ISO | IL1B (Homo sapiens) | 6480464 | CTD | Uric Acid results in increased secretion of IL1B protein | PMID:18403674 PMID:21051542 | Il1b | multiple interactions | ISO | Il1b (Mus musculus) | 6480464 | CTD | [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Uric Acid] results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Uric Acid] promotes the reaction [PYCARD protein binds to CASP1 protein binds to IL1B protein binds to NLRP3 protein]; [Lipopolysaccharides co-treated with Uric Acid] results in increased expression of and results in increased activity of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Uric Acid] results in increased expression of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Uric Acid] results in increased expression of IL1B mRNA; [Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of and results in increased cleavage of IL1B protein; [Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of IL1B protein; acetovanillone inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of IL1B protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Chloroquine inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Chlorquinaldol inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of IL1B protein]; CYBA protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of and results in increased secretion of IL1B protein]; diallyl disulfide inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of IL1B protein]; diallyl trisulfide inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] promotes the reaction [PYCARD protein binds to CASP1 protein binds to IL1B protein binds to NLRP3 protein]]; diallyl trisulfide inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased expression of and results in increased secretion of IL1B protein]; diallyl trisulfide inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased expression of IL1B mRNA]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Uric Acid] results in increased secretion of IL1B protein]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of and results in increased cleavage of IL1B protein]; NLRP3 protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased expression of IL1B protein]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of IL1B protein]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of and results in increased cleavage of IL1B protein]; PYCARD protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; TXN protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; UOX protein inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of IL1B protein]; Uric Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL1B mRNA] | PMID:18403674 PMID:18604214 PMID:21051542 PMID:23430110 PMID:24158569 PMID:33749747 PMID:36002070 PMID:36577999 PMID:36796188 | Il1b | multiple interactions | ISO | IL1B (Homo sapiens) | 6480464 | CTD | 2-(5-benzo(1,3)dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride inhibits the reaction [Uric Acid promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; [Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Uric Acid] results in increased expression of IL1B protein; [Uric Acid co-treated with TGFB1 protein] promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Ammonium Chloride inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Apigenin inhibits the reaction [Uric Acid results in increased expression of and results in increased cleavage of and results in increased secretion of IL1B protein]; AQP1 mRNA affects the reaction [Uric Acid results in increased secretion of IL1B protein]; AQP9 mRNA affects the reaction [Uric Acid results in increased secretion of IL1B protein]; CASP1 protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; Chloroquine inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of and results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; diphenyleneiodonium inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; flavone analog inhibits the reaction [Uric Acid results in increased cleavage of and results in increased secretion of IL1B protein]; latrunculin A inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Mercuric Chloride inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine inhibits the reaction [Uric Acid results in increased cleavage of and results in increased secretion of IL1B protein]; NLRP3 protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; Phloretin inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; PYCARD protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; TGFBR2 protein affects the reaction [Uric Acid promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; tyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone analog inhibits the reaction [Uric Acid results in increased cleavage of and results in increased secretion of IL1B protein]; Uric Acid promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Uric Acid results in increased expression of and results in increased cleavage of and results in increased secretion of IL1B protein | PMID:18403674 PMID:18604214 PMID:21051542 PMID:26296894 PMID:29960001 PMID:36850003 | | ||||||||||||||||||||||
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