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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:40279
Term: allopurinol
Definition: A bicyclic structure comprising a pyrazole ring fused to a hydroxy-substituted pyrimidine ring.
Chemical ID: MESH:D000493
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bmultiple interactionsEXP 6480464CTDAllopurinol inhibits the reaction [Fructose results in increased expression of IL1B protein]; Allopurinol inhibits the reaction [Glucose results in increased expression of IL1B protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of IL1B protein]PMID:22426011 PMID:23647015 PMID:24491314
Il1bdecreases expressionISOIl1b (Mus musculus)6480464CTDAllopurinol results in decreased expression of IL1B mRNAPMID:7695923
Il1bmultiple interactionsISOIl1b (Mus musculus)6480464CTD[1-Naphthylisothiocyanate co-treated with Allopurinol] results in increased expression of IL1B mRNAPMID:33749747
Il1bmultiple interactionsISOIL1B (Homo sapiens)6480464CTDAllopurinol inhibits the reaction [Glucose results in increased expression of IL1B protein]PMID:23647015
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