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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:3435
Term: carrageenan
Definition: A family of sulfated polysaccharides extracted from red seaweeds. The name is derived from a common name of red algae Chondrus crispus, 'carrageen moss' (Irish moss).
Chemical ID: MESH:D002351
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bincreases expressionEXP 6480464CTDCarrageenan results in increased expression of IL1B proteinPMID:22330755 PMID:23774260 PMID:23872256
Il1bincreases secretionEXP 6480464CTDCarrageenan results in increased secretion of IL1B proteinPMID:11181422 PMID:17320857 PMID:21549112
Il1bmultiple interactionsEXP 6480464CTD3-methylquercetin inhibits the reaction [Carrageenan results in increased expression of IL1B protein]; budlein A inhibits the reaction [Carrageenan results in increased secretion of IL1B protein]; Carrageenan promotes the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Dexamethasone inhibits the reaction [Carrageenan results in increased expression of IL1B protein]; imisopasem manganese inhibits the reaction [Carrageenan results in increased expression of IL1B protein]; IMMLG5521 inhibits the reaction [Carrageenan results in increased secretion of IL1B protein]; N-(2-hydroxybenzoyl)tyramine inhibits the reaction [Carrageenan results in increased expression of IL1B protein]PMID:11181422 PMID:17320857 PMID:21549112 PMID:22330755 PMID:23774260 PMID:23872256
Il1bincreases expressionISOIl1b (Mus musculus)6480464CTDCarrageenan results in increased expression of IL1B proteinPMID:20383154
Il1bincreases secretionISOIl1b (Mus musculus)6480464CTDCarrageenan results in increased secretion of IL1B proteinPMID:16368644 PMID:29499192
Il1bmultiple interactionsISOIl1b (Mus musculus)6480464CTD5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid inhibits the reaction [Carrageenan results in increased expression of IL1B protein]; indole-3-guanylhydrazone hydrochloride inhibits the reaction [Carrageenan results in increased secretion of IL1B protein]; Indomethacin inhibits the reaction [Carrageenan results in increased secretion of IL1B protein]PMID:20383154 PMID:29499192
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