GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Il1b | decreases expression | ISO | IL1B (Homo sapiens) | 6480464 | CTD | Folic Acid results in decreased expression of IL1B mRNA | PMID:30116142 | Il1b | decreases secretion | ISO | IL1B (Homo sapiens) | 6480464 | CTD | Folic Acid results in decreased secretion of IL1B protein | PMID:30116142 | Il1b | increases expression | ISO | Il1b (Mus musculus) | 6480464 | CTD | Folic Acid deficiency results in increased expression of IL1B protein; Folic Acid results in increased expression of IL1B mRNA; Folic Acid results in increased expression of IL1B protein | PMID:22647887 PMID:25629700 PMID:31593741 PMID:34619300 | Il1b | increases methylation | ISO | IL1B (Homo sapiens) | 6480464 | CTD | Folic Acid results in increased methylation of IL1B gene | PMID:30116142 | Il1b | multiple interactions | ISO | Il1b (Mus musculus) | 6480464 | CTD | CASP1 protein affects the reaction [Folic Acid deficiency results in increased expression of IL1B protein]; Folic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B mRNA]; Folic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL1B protein]; Folic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Folic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B]; Folic Acid inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; nilotinib inhibits the reaction [Folic Acid results in increased expression of IL1B protein]; PYCARD protein affects the reaction [Folic Acid deficiency results in increased expression of IL1B protein] | PMID:21528358 PMID:22647887 PMID:24177262 PMID:27738387 PMID:31593741 | Il1b | multiple interactions | ISO | IL1B (Homo sapiens) | 6480464 | CTD | [Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in decreased expression of IL1B mRNA; [Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in decreased secretion of IL1B protein; [Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased methylation of IL1B gene; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide promotes the reaction [Folic Acid inhibits the reaction [Oxygen deficiency results in increased expression of IL1B mRNA]]; Folic Acid inhibits the reaction [dimethyloxallyl glycine results in increased secretion of IL1B protein]; Folic Acid inhibits the reaction [INS protein results in increased secretion of IL1B protein]; Folic Acid inhibits the reaction [Oxygen deficiency results in increased expression of IL1B mRNA]; Folic Acid inhibits the reaction [Oxygen deficiency results in increased secretion of IL1B protein] | PMID:26974319 PMID:29685624 PMID:30116142 | | ||||||||||||||||||||||
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