GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Il1b | decreases expression | EXP | | 6480464 | CTD | Methotrexate results in decreased expression of IL1B protein | PMID:18535404 | Il1b | increases expression | EXP | | 6480464 | CTD | Methotrexate results in increased expression of IL1B; Methotrexate results in increased expression of IL1B mRNA; Methotrexate results in increased expression of IL1B protein | PMID:26517535 PMID:28414158 PMID:29027214 PMID:33720507 PMID:34737150 PMID:36249937 PMID:36482745 PMID:37341015 PMID:37866152 | Il1b | multiple interactions | EXP | | 6480464 | CTD | 18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in increased expression of IL1B protein]; Buspirone inhibits the reaction [Methotrexate results in increased expression of IL1B protein]; mangiferin inhibits the reaction [Methotrexate results in increased expression of IL1B protein]; Methotrexate inhibits the reaction [Freund's Adjuvant results in increased expression of IL1B mRNA]; Methotrexate inhibits the reaction [Freund's Adjuvant results in increased expression of IL1B protein]; Methotrexate inhibits the reaction [Freund's Adjuvant results in increased secretion of IL1B protein]; Methotrexate promotes the reaction [T 614 results in decreased expression of IL1B protein]; Perindopril inhibits the reaction [Methotrexate results in increased expression of IL1B protein]; pinostrobin inhibits the reaction [Methotrexate results in increased expression of IL1B protein]; ramelteon inhibits the reaction [Methotrexate results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [Methotrexate results in increased expression of IL1B]; sinapinic acid inhibits the reaction [Methotrexate results in increased expression of IL1B protein] | PMID:19019215 PMID:26517535 PMID:27613480 PMID:28414158 PMID:33720507 PMID:34737150 PMID:36249937 PMID:36482745 PMID:37341015 PMID:37866152 | Il1b | increases expression | ISO | IL1B (Homo sapiens) | 6480464 | CTD | Methotrexate results in increased expression of IL1B mRNA; Methotrexate results in increased expression of IL1B protein | PMID:17379860 PMID:19100307 PMID:21678067 PMID:24444433 PMID:29027214 | Il1b | increases secretion | ISO | IL1B (Homo sapiens) | 6480464 | CTD | Methotrexate results in increased secretion of IL1B protein | PMID:24444433 PMID:27605418 | Il1b | multiple interactions | ISO | Il1b (Mus musculus) | 6480464 | CTD | [Cyclophosphamide co-treated with Methotrexate co-treated with Fluorouracil] results in decreased expression of IL1B protein | PMID:31651976 | Il1b | multiple interactions | ISO | IL1B (Homo sapiens) | 6480464 | CTD | [Methotrexate analog binds to Lipids] which results in decreased expression of IL1B mRNA; Leucovorin inhibits the reaction [Methotrexate results in increased expression of IL1B mRNA]; Methotrexate inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Methotrexate results in increased expression of and results in increased secretion of IL1B protein; parthenolide inhibits the reaction [Methotrexate results in increased expression of IL1B mRNA]; parthenolide inhibits the reaction [Methotrexate results in increased secretion of IL1B protein]; SB 203580 inhibits the reaction [Methotrexate results in increased expression of IL1B protein] | PMID:16393772 PMID:19100307 PMID:24065615 PMID:24444433 PMID:25330300 | | ||||||||||||||||||||||
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