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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891 Species: Rattus norvegicus RGD Object: Gene Symbol: Il1b Name: interleukin 1 beta

Acc ID: CHEBI:6015 Term: isoflurane Definition: An organofluorine compound that has formula C3H2ClF5O. CasRN: 26675-46-7 Chemical ID: MESH:D007530

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:10790	6480464	CTD	Isoflurane results in decreased expression of IL1B mRNA	PMID:17414419
increases expression	EXP		6480464	CTD	Isoflurane results in increased expression of IL1B mRNA	PMID:10422944