RGD Reference Report - Long-Term Binge and Escalating Ethanol Exposure Causes Necroinflammation and Fibrosis in Rat Liver. - Rat Genome Database

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Long-Term Binge and Escalating Ethanol Exposure Causes Necroinflammation and Fibrosis in Rat Liver.

Authors: Zhou, JY  Jiang, ZA  Zhao, CY  Zhen, Z  Wang, W  Nanji, AA 
Citation: Zhou JY, etal., Alcohol Clin Exp Res. 2012 Sep 25. doi: 10.1111/j.1530-0277.2012.01936.x.
RGD ID: 7204488
Pubmed: PMID:23009062   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1530-0277.2012.01936.x   (Journal Full-text)

BACKGROUND: To investigate whether "binge" and escalating alcohol exposure in the rat influences the development of pathological liver injury. METHODS: Time courses for the formation of eicosanoids by cyclooxygenase (COX), oxidative stress and nitrosative stress production, expression of hypoxia-inducible factor 1 (HIF-1), cytokines, hepatic tissue necroinflammation, and fibrosis were assessed in rats during 16 weeks of daily alcohol gavage. RESULTS: In this model of binge and escalating levels of alcohol, hepatic steatosis, necrosis, and inflammation as well as fibrosis were increased over the 16-week period. The levels of COX-2, oxidative stress, nitrosative stress, HIF-1, proinflammatory mediators (tumor necrosis factor-alpha, interleukin 1(beta) [IL-1(beta) ], IL-6), and procollagen-I were increased over the 16-week period. The content of IL-10 in rat serum increased at the end of 4 and 8 weeks but decreased thereafter and was significantly decreased at 12 and 16 weeks. CONCLUSIONS: A rat model of alcoholic liver disease (ALD) with long-term binge and escalating ethanol exposure was developed. Our data support the hypothesis that enhanced eicosanoid production by COX, oxidative stress and nitrosative stress, HIF-1, and the imbalance between pro- and anti-inflammatory cytokines plays an important role in the pathogenesis of ALD.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Alcoholic Liver Diseases  ISOIl1b (Rattus norvegicus)7204488; 7204488protein:increased expression:serum (rat)RGD 
Alcoholic Liver Diseases  IEP 7204488protein:increased expression:serum (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il1b  (interleukin 1 beta)

Genes (Mus musculus)
Il1b  (interleukin 1 beta)

Genes (Homo sapiens)
IL1B  (interleukin 1 beta)


Additional Information