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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:64317
Term: isoprenaline
Definition: A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Chemical ID: MESH:D007545
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bdecreases expressionEXP 6480464CTDIsoproterenol results in decreased expression of IL1B mRNA; Isoproterenol results in decreased expression of IL1B proteinPMID:24286936
Il1bincreases expressionEXP 6480464CTDIsoproterenol results in increased expression of IL1B; Isoproterenol results in increased expression of IL1B mRNA; Isoproterenol results in increased expression of IL1B proteinPMID:12215284 PMID:18487443 PMID:19904010 PMID:21762681 PMID:24286936 PMID:25045214 PMID:35014750 PMID:35305975 PMID:35430261 PMID:35815753 PMID:36593721 PMID:37806379 PMID:9387890
Il1bmultiple interactionsEXP 6480464CTD5-Methoxypsoralen inhibits the reaction [Isoproterenol results in increased expression of IL1B protein]; anethole inhibits the reaction [Isoproterenol results in increased expression of IL1B protein]; Ellagic Acid inhibits the reaction [Isoproterenol results in increased expression of IL1B mRNA]; Glyburide promotes the reaction [Isoproterenol results in increased expression of IL1B protein]; protocatechuic acid inhibits the reaction [Isoproterenol results in increased expression of IL1B protein]; punicalagin inhibits the reaction [Isoproterenol results in increased expression of IL1B protein]; pyrvinium inhibits the reaction [Glyburide promotes the reaction [Isoproterenol results in increased expression of IL1B protein]]; pyrvinium inhibits the reaction [Isoproterenol results in increased expression of IL1B protein]; Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL1B mRNA]; Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL1B protein]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL1B mRNA]]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL1B protein]]PMID:21762681 PMID:25045214 PMID:35305975 PMID:35430261 PMID:35815753 PMID:36593721 PMID:37806379
Il1bdecreases expressionISOIL1B (Homo sapiens)6480464CTDIsoproterenol results in decreased expression of IL1B mRNAPMID:32816093
Il1bincreases expressionISOIl1b (Mus musculus)6480464CTDIsoproterenol results in increased expression of IL1B; Isoproterenol results in increased expression of IL1B mRNAPMID:15302781 PMID:19023134 PMID:21335049
Il1bincreases expressionISOIL1B (Homo sapiens)6480464CTDIsoproterenol results in increased expression of IL1B mRNA; Isoproterenol results in increased expression of IL1B proteinPMID:24286936
Il1bmultiple interactionsISOIl1b (Mus musculus)6480464CTDSB 206553 inhibits the reaction [Isoproterenol results in increased expression of IL1B]; ZD 7155 inhibits the reaction [Isoproterenol results in increased expression of IL1B protein]PMID:15302781 PMID:19023134
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