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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:16842
Term: formaldehyde
Definition: An aldehyde resulting from the formal oxidation of methanol.
Chemical ID: MESH:D005557
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bincreases expressionEXP 6480464CTDFormaldehyde results in increased expression of IL1B proteinPMID:20658762 PMID:21983654
Il1bmultiple interactionsEXP 6480464CTD[Capsaicin results in increased susceptibility to Formaldehyde] which results in increased expression of IL1B mRNA; acetovanillone inhibits the reaction [Formaldehyde results in increased expression of IL1B protein]; Indomethacin inhibits the reaction [Formaldehyde results in increased expression of IL1B protein]PMID:21983654 PMID:28005965
Il1baffects expressionISOIl1b (Mus musculus)6480464CTDFormaldehyde affects the expression of IL1B proteinPMID:29315975
Il1bdecreases expressionISOIl1b (Mus musculus)6480464CTDFormaldehyde results in decreased expression of IL1B proteinPMID:15003329
Il1bdecreases expressionISOIL1B (Homo sapiens)6480464CTDFormaldehyde results in decreased expression of IL1B mRNAPMID:29594315
Il1bincreases expressionISOIl1b (Mus musculus)6480464CTDFormaldehyde results in increased expression of IL1B proteinPMID:30395894
Il1bincreases expressionISOIL1B (Homo sapiens)6480464CTDFormaldehyde results in increased expression of IL1B mRNAPMID:27664576
Il1bmultiple interactionsISOIl1b (Mus musculus)6480464CTD2-amino-3-(4'-N,N-bis(2-chloroethyl)amino)phenylpropionic acid N-oxide inhibits the reaction [[Formaldehyde co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]; [Ovalbumin co-treated with Formaldehyde] results in increased expression of and results in increased secretion of IL1B protein; [Rutin co-treated with Meloxicam] affects the reaction [Formaldehyde affects the expression of IL1B protein]; epigallocatechin gallate inhibits the reaction [Formaldehyde results in increased expression of IL1B protein]; Formaldehyde promotes the reaction [ovalbumin-alum results in increased secretion of IL1B protein]; Meloxicam affects the reaction [Formaldehyde affects the expression of IL1B protein]; Rutin affects the reaction [Formaldehyde affects the expression of IL1B protein]PMID:23671638 PMID:29315975 PMID:30395894 PMID:37105513
Il1bmultiple interactionsISOIL1B (Homo sapiens)6480464CTDFormaldehyde results in increased expression of and results in increased secretion of IL1B proteinPMID:18082304
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