RGD Reference Report - Bradykinin receptor 1 activation exacerbates experimental focal and segmental glomerulosclerosis. - Rat Genome Database

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Bradykinin receptor 1 activation exacerbates experimental focal and segmental glomerulosclerosis.

Authors: Pereira, RL  Buscariollo, BN  Correa-Costa, M  Semedo, P  Oliveira, CD  Reis, VO  Maquigussa, E  Araujo, RC  Braga, TT  Soares, MF  Moura, IC  Malheiros, DM  Filho, AP  Keller, AC  Camara, NO 
Citation: Pereira RL, etal., Kidney Int. 2011 Jun;79(11):1217-27. doi: 10.1038/ki.2011.14. Epub 2011 Mar 16.
RGD ID: 7175321
Pubmed: PMID:21412216   (View Abstract at PubMed)
DOI: DOI:10.1038/ki.2011.14   (Journal Full-text)

Focal and segmental glomerulosclerosis (FSGS) is one of the most important causes of end-stage renal failure. The bradykinin B1 receptor has been associated with tissue inflammation and renal fibrosis. To test for a role of the bradykinin B1 receptor in podocyte injury, we pharmacologically modulated its activity at different time points in an adriamycin-induced mouse model of FSGS. Estimated albuminuria and urinary protein to creatinine ratios correlated with podocytopathy. Adriamycin injection led to loss of body weight, proteinuria, and upregulation of B1 receptor mRNA. Early treatment with a B1 antagonist reduced albuminuria and glomerulosclerosis, and inhibited the adriamycin-induced downregulation of podocin, nephrin, and alpha-actinin-4 expression. Moreover, delayed treatment with antagonist also induced podocyte protection. Conversely, a B1 agonist aggravated renal dysfunction and even further suppressed the levels of podocyte-related molecules. Thus, we propose that kinin has a crucial role in the pathogenesis of FSGS operating through bradykinin B1 receptor signaling.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Objects Annotated

Genes (Rattus norvegicus)
Bdkrb1  (bradykinin receptor B1)
Il1b  (interleukin 1 beta)

Genes (Mus musculus)
Bdkrb1  (bradykinin receptor, beta 1)
Il1b  (interleukin 1 beta)

Genes (Homo sapiens)
BDKRB1  (bradykinin receptor B1)
IL1B  (interleukin 1 beta)


Additional Information