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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:5134
Term: fluticasone
Definition: A trifluorinated corticosteroid used in the form of its propionate ester for treatment of allergic rhinitis.
Chemical ID: MESH:C065382
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bmultiple interactionsISOIL1B (Homo sapiens)6480464CTDFluticasone inhibits the reaction [IL1B protein results in increased expression of SELE mRNA]; Fluticasone inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]; Fluticasone inhibits the reaction [Particulate Matter results in increased expression of IL1B mRNA]; Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of IL1B protein]; Mifepristone inhibits the reaction [Fluticasone inhibits the reaction [IL1B protein results in increased expression of SELE mRNA]]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of IL1B protein]]PMID:10460758 PMID:31822346 PMID:9371735
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