PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: endometrial cancer pathway
Accession: PW:0000611
browse the term
Definition: Endometrial cancer affects the lining of the uterus, or endometrium. Hormonal and genetic alterations play a role in the development of this carcinoma type. Mutations in genes acting in several pathways have been associated with the condition and its types.
Synonyms: related_synonym: KEGG:05213; endometrial neoplasm pathway
View Interactive Diagram
G
Akt1
AKT serine/threonine kinase 1
IEA
KEGG
rno:05213
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
G
Akt2
AKT serine/threonine kinase 2
severity
IEA ISO
KEGG RGD
PMID:22146979
rno:05213, RGD:13432140
NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
G
Akt3
AKT serine/threonine kinase 3
IEA
KEGG
rno:05213
NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708
G
Apc
APC regulator of WNT signaling pathway
IEA ISO
KEGG RGD
PMID:12439748
rno:05213, RGD:13432145
NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
G
Apc2
APC regulator of WNT signaling pathway 2
IEA
KEGG
rno:05213
NCBI chr 7:9,392,336...9,414,364
Ensembl chr 7:9,392,336...9,414,310
G
Axin1
axin 1
IEA
KEGG
rno:05213
NCBI chr10:15,163,477...15,215,615
Ensembl chr10:15,163,684...15,215,615
G
Axin2
axin 2
IEA ISO
KEGG RGD
PMID:25144715
rno:05213, RGD:13432159
NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231
G
Bad
BCL2-associated agonist of cell death
IEA ISO
KEGG RGD
PMID:12790783
rno:05213, RGD:13432162
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
G
Braf
B-Raf proto-oncogene, serine/threonine kinase
IEA
KEGG
rno:05213
NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
G
Casp9
caspase 9
IEA ISO
KEGG RGD
PMID:17121923
rno:05213, RGD:13432196
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
G
Ccnd1
cyclin D1
IEA
KEGG
rno:05213
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
G
Cdh1
cadherin 1
IEA
KEGG
rno:05213
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
G
Ctnna1
catenin alpha 1
IEA
KEGG
rno:05213
NCBI chr18:26,728,246...26,860,911
Ensembl chr18:26,728,485...26,860,910
G
Ctnna2
catenin alpha 2
IEA
KEGG
rno:05213
NCBI chr 4:109,294,249...110,443,409
Ensembl chr 4:109,293,978...110,443,522
G
Ctnna3
catenin alpha 3
IEA
KEGG
rno:05213
NCBI chr20:23,614,469...25,200,026
Ensembl chr20:23,623,560...25,199,978
G
Ctnnb1
catenin beta 1
ISO IEA
KEGG RGD
PMID:19078924
rno:05213, RGD:4143515
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
G
Egf
epidermal growth factor
IEA
KEGG
rno:05213
NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
G
Egfr
epidermal growth factor receptor
IEA
KEGG
rno:05213
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
G
Elk1
ETS transcription factor ELK1
IEA
KEGG
rno:05213
NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713
G
Erbb2
erb-b2 receptor tyrosine kinase 2
ISO IEA
KEGG RGD
PMID:19078924
rno:05213, RGD:4143515
NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
G
Foxo3
forkhead box O3
IEA
KEGG
rno:05213
NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
G
Grb2
growth factor receptor bound protein 2
IEA
KEGG
rno:05213
NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309
G
Gsk3b
glycogen synthase kinase 3 beta
IEA
KEGG
rno:05213
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
G
Hras
HRas proto-oncogene, GTPase
IEA
KEGG
rno:05213
NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
G
Ilk
integrin-linked kinase
IEA
KEGG
rno:05213
NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140
G
Kras
KRAS proto-oncogene, GTPase
ISO IEA
KEGG RGD
PMID:19078924
rno:05213, RGD:4143515
NCBI chr 4:178,185,418...178,218,484
G
Lef1
lymphoid enhancer binding factor 1
IEA
KEGG
rno:05213
NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794
G
Map2k1
mitogen activated protein kinase kinase 1
IEA
KEGG
rno:05213
NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
G
Map2k2
mitogen activated protein kinase kinase 2
IEA
KEGG
rno:05213
NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
G
Mapk1
mitogen activated protein kinase 1
IEA
KEGG
rno:05213
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
IEA
KEGG
rno:05213
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
G
Mlh1
mutL homolog 1
ISO IEA
KEGG RGD
PMID:19078924
rno:05213, RGD:4143515
NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617
G
Msh6
mutS homolog 6
ISO
RGD
PMID:19078924
RGD:4143515
NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956
G
Myc
MYC proto-oncogene, bHLH transcription factor
IEA
KEGG
rno:05213
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
G
Nras
NRAS proto-oncogene, GTPase
IEA
KEGG
rno:05213
NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626
G
Pdpk1
3-phosphoinositide dependent protein kinase-1
IEA
KEGG
rno:05213
NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623
G
Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
ISO IEA
KEGG RGD
PMID:19078924
rno:05213, RGD:4143515
NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
G
Pik3cb
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
IEA
KEGG
rno:05213
NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663
G
Pik3cd
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
IEA
KEGG
rno:05213
NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930
G
Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
IEA
KEGG
rno:05213
NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
G
Pik3r2
phosphoinositide-3-kinase regulatory subunit 2
IEA
KEGG
rno:05213
NCBI chr16:18,665,517...18,674,067
Ensembl chr16:18,665,457...18,674,065
G
Pik3r3
phosphoinositide-3-kinase regulatory subunit 3
IEA
KEGG
rno:05213
NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583
G
Pik3r5
phosphoinositide-3-kinase, regulatory subunit 5
IEA
KEGG
rno:05213
NCBI chr10:53,132,585...53,200,663
Ensembl chr10:53,132,603...53,199,374
G
Pten
phosphatase and tensin homolog
ISO IEA
KEGG RGD
PMID:19078924
rno:05213, RGD:4143515
NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
G
Raf1
Raf-1 proto-oncogene, serine/threonine kinase
IEA
KEGG
rno:05213
NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
G
Sos1
SOS Ras/Rac guanine nucleotide exchange factor 1
IEA
KEGG
rno:05213
NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107
G
Sos2
SOS Ras/Rho guanine nucleotide exchange factor 2
IEA
KEGG
rno:05213
NCBI chr 6:88,042,966...88,156,140
Ensembl chr 6:88,042,966...88,156,692
G
Tcf3
transcription factor 3
IEA
KEGG
rno:05213
NCBI chr 7:9,280,571...9,302,315
Ensembl chr 7:9,280,571...9,302,314
G
Tcf7
transcription factor 7
IEA
KEGG
rno:05213
NCBI chr10:36,423,443...36,454,350
Ensembl chr10:36,423,445...36,453,535
G
Tcf7l2
transcription factor 7 like 2
IEA
KEGG
rno:05213
NCBI chr 1:254,785,956...254,978,967
Ensembl chr 1:254,786,091...254,978,967
G
Tp53
tumor protein p53
ISO IEA
KEGG RGD
PMID:19078924
rno:05213, RGD:4143515
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all