ONTOLOGY REPORT - ANNOTATIONS |
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Term: | stress-activated protein kinase signaling cascade |
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Accession: | GO:0031098
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browse the term
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Definition: | The series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays a signal. |
Synonyms: | exact_synonym: | SAPK signaling pathway; SAPK signalling pathway; stress-activated protein kinase signaling pathway; stress-activated protein kinase signalling pathway |
| narrow_synonym: | JNK signaling pathway; JNK signalling pathway |
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Akr1b1 |
aldo-keto reductase family 1 member B1 |
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IMP |
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RGD |
PMID:16669970 |
RGD:1626090 |
NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
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Gfral |
GDNF family receptor alpha like |
involved_in acts_upstream_of_or_within |
IEA ISO |
GO_REF:0000107 (PMID:16086688) |
Ensembl RGD |
PMID:16086688 |
GO_REF:0000107 |
NCBI chr 8:76,917,894...76,963,258
Ensembl chr 8:76,918,657...76,959,425
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Kat7 |
lysine acetyltransferase 7 |
involved_in |
ISO |
(PMID:21856198) |
RGD |
PMID:21856198 |
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NCBI chr10:80,221,519...80,255,590
Ensembl chr10:80,221,524...80,255,567
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Map2k3 |
mitogen activated protein kinase kinase 3 |
involved_in |
ISO |
(PMID:8622669) |
RGD |
PMID:8622669 |
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NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492
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Map2k6 |
mitogen-activated protein kinase kinase 6 |
involved_in |
ISO |
(PMID:35857590) |
RGD |
PMID:35857590 |
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NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293
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Map3k20 |
mitogen-activated protein kinase kinase kinase 20 |
involved_in |
ISO |
(PMID:35857590) |
RGD |
PMID:35857590 |
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NCBI chr 3:57,130,539...57,289,943
Ensembl chr 3:57,130,551...57,289,626
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Mapk11 |
mitogen-activated protein kinase 11 |
involved_in |
ISO |
(PMID:35857590) |
RGD |
PMID:35857590 |
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NCBI chr 7:120,218,471...120,225,488
Ensembl chr 7:120,218,478...120,225,395
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Mapk14 |
mitogen activated protein kinase 14 |
involved_in |
ISO |
(PMID:35857590) |
RGD |
PMID:35857590 |
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NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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Rhoa |
ras homolog family member A |
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IMP |
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RGD |
PMID:17369826 |
RGD:1642964 |
NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
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Usp25 |
ubiquitin specific peptidase 25 |
involved_in |
ISO |
MGI:4332130 (PMID:23042150) |
RGD |
PMID:23042150 |
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NCBI chr11:15,603,654...15,711,356
Ensembl chr11:15,603,881...15,711,348
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Dusp10 |
dual specificity phosphatase 10 |
acts_upstream_of_or_within |
ISO |
MGI:3052343 (PMID:19696743) |
RGD |
PMID:19696743 |
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NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716
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Foxm1 |
forkhead box M1 |
involved_in |
ISO IEA |
(PMID:19696738) GO_REF:0000107 |
RGD Ensembl |
PMID:19696738 |
GO_REF:0000107 |
NCBI chr 4:161,639,538...161,652,012
Ensembl chr 4:161,638,816...161,650,684
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Foxo1 |
forkhead box O1 |
involved_in |
ISO |
(PMID:19696738) |
RGD |
PMID:19696738 |
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NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
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Gstp1 |
glutathione S-transferase pi 1 |
involved_in |
ISS ISO |
GO_REF:0000024 (PMID:16023107) |
BHF-UCL RGD |
PMID:16023107 |
GO_REF:0000024 |
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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Igbp1 |
immunoglobulin binding protein 1 |
involved_in |
ISO |
(PMID:17438131) |
RGD |
PMID:17438131 |
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NCBI chr X:65,582,832...65,605,078
Ensembl chr X:65,582,821...65,606,049
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Myc |
MYC proto-oncogene, bHLH transcription factor |
involved_in |
ISO |
(PMID:19545562) |
RGD |
PMID:19545562 |
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NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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Pbk |
PDZ binding kinase |
acts_upstream_of_or_within |
ISO |
MGI:5293435 (PMID:21715333) |
RGD |
PMID:21715333 |
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NCBI chr15:40,022,873...40,034,014
Ensembl chr15:40,023,002...40,034,014
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Ppia |
peptidylprolyl isomerase A |
involved_in |
ISS ISO |
GO_REF:0000024 (PMID:26095851) |
UniProt RGD |
PMID:26095851 |
GO_REF:0000024 |
NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601
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Ppial4d |
peptidylprolyl isomerase A (cyclophilin A)-like 4D |
involved_in |
ISS |
GO_REF:0000024 |
UniProt |
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GO_REF:0000024 |
NCBI chr14:21,006,522...21,007,284
Ensembl chr14:21,006,538...21,007,310
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Qars1 |
glutaminyl-tRNA synthetase 1 |
involved_in |
ISO IEA |
(PMID:11096076) GO_REF:0000107 |
RGD Ensembl |
PMID:11096076 |
GO_REF:0000107 |
NCBI chr 8:109,207,705...109,215,738
Ensembl chr 8:109,207,705...109,215,739
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Map3k20 |
mitogen-activated protein kinase kinase kinase 20 |
involved_in |
ISO |
(PMID:35857590) |
RGD |
PMID:35857590 |
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NCBI chr 3:57,130,539...57,289,943
Ensembl chr 3:57,130,551...57,289,626
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Arl6ip5 |
ARF like GTPase 6 interacting protein 5 |
involved_in |
IEA ISO |
GO_REF:0000107 (PMID:18387645) |
Ensembl RGD |
PMID:18387645 |
GO_REF:0000107 |
NCBI chr 4:129,810,650...129,838,628
Ensembl chr 4:129,810,645...129,838,608
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Card9 |
caspase recruitment domain family, member 9 |
involved_in acts_upstream_of_or_within |
ISS ISO |
GO_REF:0000024 (PMID:29080677) MGI:3698412 (PMID:17187069) |
UniProt RGD |
PMID:17187069 PMID:29080677 |
GO_REF:0000024 |
NCBI chr 3:9,171,814...9,180,310
Ensembl chr 3:9,171,815...9,180,237
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Clec7a |
C-type lectin domain containing 7A |
involved_in |
ISO |
(PMID:27288407) |
RGD |
PMID:27288407 |
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NCBI chr 4:162,902,731...162,913,931
Ensembl chr 4:162,902,732...162,913,897
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Crhr2 |
corticotropin releasing hormone receptor 2 |
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IMP |
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RGD |
PMID:19211730 |
RGD:5130956 |
NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904
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Eif2ak2 |
eukaryotic translation initiation factor 2-alpha kinase 2 |
involved_in |
ISS ISO |
GO_REF:0000024 (PMID:20038207) |
UniProt RGD |
PMID:20038207 |
GO_REF:0000024 |
NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971
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Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
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IMP |
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RGD |
PMID:17161379 |
RGD:5508698 |
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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Igfbp6 |
insulin-like growth factor binding protein 6 |
involved_in |
ISO |
(PMID:24003225) |
RGD |
PMID:24003225 |
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NCBI chr 7:133,276,309...133,280,944
Ensembl chr 7:133,276,234...133,280,966
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Il1a |
interleukin 1 alpha |
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IDA |
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RGD |
PMID:15671867 |
RGD:1358666 |
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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Il1b |
interleukin 1 beta |
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IMP IDA |
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RGD |
PMID:12629164 PMID:15671867 |
RGD:1626685, RGD:1358666 |
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Inava |
innate immunity activator |
involved_in |
ISO |
(PMID:28436939) |
RGD |
PMID:28436939 |
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NCBI chr13:47,666,446...47,687,383
Ensembl chr13:47,666,447...47,686,729
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Kiss1 |
KiSS-1 metastasis-suppressor |
NOT |
IMP |
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RGD |
PMID:16222076 |
RGD:1599289 |
NCBI chr13:44,775,106...44,780,707
Ensembl chr13:44,774,823...44,780,612
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Klhdc10 |
kelch domain containing 10 |
involved_in |
IBA |
GO_REF:0000033 |
GO_Central |
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GO_REF:0000033 |
NCBI chr 4:59,021,300...59,079,118
Ensembl chr 4:59,021,310...59,074,941
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Mapk8ip2 |
mitogen-activated protein kinase 8 interacting protein 2 |
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IMP |
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RGD |
PMID:12024021 |
RGD:2302280 |
NCBI chr 7:120,526,732...120,536,982
Ensembl chr 7:120,526,732...120,536,982
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Mid1 |
midline 1 |
involved_in |
ISO |
(PMID:17438131) |
RGD |
PMID:17438131 |
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NCBI chr X:24,116,674...24,491,205
Ensembl chr X:24,120,293...24,248,353
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Nod1 |
nucleotide-binding oligomerization domain containing 1 |
acts_upstream_of_or_within |
ISO |
(PMID:18261938) |
RGD |
PMID:18261938 |
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NCBI chr 4:84,060,871...84,111,668
Ensembl chr 4:84,060,880...84,111,404
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Nod2 |
nucleotide-binding oligomerization domain containing 2 |
acts_upstream_of_or_within |
ISO |
(PMID:17187069) (PMID:18261938) |
RGD |
PMID:17187069 PMID:18261938 |
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NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177
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Pdcd10 |
programmed cell death 10 |
involved_in |
ISO IEA |
(PMID:22652780) GO_REF:0000107 |
RGD Ensembl |
PMID:22652780 |
GO_REF:0000107 |
NCBI chr 2:160,303,465...160,346,086
Ensembl chr 2:160,303,449...160,346,018
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Ripk2 |
receptor-interacting serine-threonine kinase 2 |
acts_upstream_of_or_within |
ISO |
MGI:2446070|MGI:2660793 (PMID:11894097), (PMID:11894098), (PMID:18261938) |
RGD |
PMID:11894097 PMID:11894098 PMID:18261938 |
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NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657
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Scimp |
SLP adaptor and CSK interacting membrane protein |
involved_in |
ISO |
(PMID:27288407) |
RGD |
PMID:27288407 |
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NCBI chr10:55,507,646...55,527,764
Ensembl chr10:55,507,519...55,528,171
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Sema4c |
semaphorin 4C |
involved_in |
ISO |
(PMID:17498836) |
RGD |
PMID:17498836 |
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NCBI chr 9:38,791,668...38,802,171
Ensembl chr 9:38,791,670...38,802,128
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Stk25 |
serine/threonine kinase 25 |
involved_in |
ISO |
(PMID:22652780) |
RGD |
PMID:22652780 |
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NCBI chr 9:94,161,834...94,174,095
Ensembl chr 9:94,161,836...94,174,244
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Taok1 |
TAO kinase 1 |
involved_in |
ISO IBA ISS |
(PMID:17396146) GO_REF:0000033 GO_REF:0000024 |
RGD GO_Central UniProt |
PMID:17396146 |
GO_REF:0000024 GO_REF:0000033 |
NCBI chr10:62,373,072...62,465,295
Ensembl chr10:62,381,404...62,465,766
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Taok2 |
TAO kinase 2 |
involved_in |
ISO IEA ISS |
(PMID:17396146) GO_REF:0000107 GO_REF:0000024 |
RGD Ensembl UniProt |
PMID:17396146 |
GO_REF:0000024 GO_REF:0000107 |
NCBI chr 1:181,475,708...181,494,738
Ensembl chr 1:181,475,711...181,494,613
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Taok3 |
TAO kinase 3 |
involved_in |
ISS IEA ISO |
GO_REF:0000024 GO_REF:0000107 (PMID:17396146) |
UniProt Ensembl RGD |
PMID:17396146 |
GO_REF:0000024 GO_REF:0000107 |
NCBI chr12:39,312,354...39,473,656
Ensembl chr12:39,314,027...39,461,244
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Tgfb2 |
transforming growth factor, beta 2 |
involved_in |
ISS ISO |
GO_REF:0000024 (PMID:17192487) |
AgBase RGD |
PMID:17192487 |
GO_REF:0000024 |
NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
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Tlr4 |
toll-like receptor 4 |
involved_in acts_upstream_of_or_within |
IEA ISO |
GO_REF:0000107 (PMID:18261938) |
Ensembl RGD |
PMID:18261938 |
GO_REF:0000107 |
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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G |
ENSRNOG00000067941 |
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involved_in |
IEA |
GO_REF:0000117 |
UniProt |
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GO_REF:0000117 |
Ensembl chr11:42,352,734...42,354,134
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Fas |
Fas cell surface death receptor |
involved_in |
ISO IBA |
(PMID:11096076) GO_REF:0000033 |
RGD GO_Central |
PMID:11096076 |
GO_REF:0000033 |
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Grem1 |
gremlin 1, DAN family BMP antagonist |
NOT|involved_in |
ISO |
(PMID:12135612) |
RGD |
PMID:12135612 |
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NCBI chr 3:100,512,317...100,524,001
Ensembl chr 3:100,512,313...100,524,082
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Gstp1 |
glutathione S-transferase pi 1 |
involved_in |
ISS ISO |
GO_REF:0000024 (PMID:10945608) |
BHF-UCL RGD |
PMID:10945608 |
GO_REF:0000024 |
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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Map2k1 |
mitogen activated protein kinase kinase 1 |
involved_in |
TAS IEA |
PMID:19565474 GO_REF:0000117 |
UniProt |
PMID:19565474 |
GO_REF:0000117, RGD:8553538 |
NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
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Map2k2 |
mitogen activated protein kinase kinase 2 |
involved_in |
TAS IEA |
PMID:19565474 GO_REF:0000117 |
UniProt |
PMID:19565474 |
GO_REF:0000117, RGD:8553538 |
NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
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Mapk1 |
mitogen activated protein kinase 1 |
involved_in |
TAS IEA |
PMID:19565474 GO_REF:0000117 |
UniProt |
PMID:19565474 |
GO_REF:0000117, RGD:8553538 |
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
involved_in |
TAS IEA |
PMID:19565474 GO_REF:0000117 |
UniProt |
PMID:19565474 |
GO_REF:0000117, RGD:8553538 |
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Nbr1 |
NBR1, autophagy cargo receptor |
involved_in |
IEA ISO |
GO_REF:0000107 (PMID:20616007) |
Ensembl RGD |
PMID:20616007 |
GO_REF:0000107 |
NCBI chr10:86,477,775...86,506,418
Ensembl chr10:86,478,290...86,506,412
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Prdx1 |
peroxiredoxin 1 |
acts_upstream_of_or_within |
ISO |
(PMID:16880205) |
RGD |
PMID:16880205 |
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NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856
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Zmpste24 |
zinc metallopeptidase STE24 |
acts_upstream_of_or_within |
ISO |
MGI:2180033 (PMID:16079796) |
RGD |
PMID:16079796 |
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NCBI chr 5:134,627,218...134,660,360
Ensembl chr 5:134,627,229...134,660,110
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Agt |
angiotensinogen |
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IDA |
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RGD |
PMID:21367774 |
RGD:5129174 |
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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Card9 |
caspase recruitment domain family, member 9 |
acts_upstream_of |
ISO |
MGI:3698412 (PMID:17187069) |
RGD |
PMID:17187069 |
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NCBI chr 3:9,171,814...9,180,310
Ensembl chr 3:9,171,815...9,180,237
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Cd2ap |
CD2-associated protein |
involved_in acts_upstream_of_or_within |
IEA ISO |
GO_REF:0000107 MGI:2664945 (PMID:15213232) |
Ensembl RGD |
PMID:15213232 |
GO_REF:0000107 |
NCBI chr 9:18,086,744...18,182,744
Ensembl chr 9:18,086,984...18,182,199
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Cryab |
crystallin, alpha B |
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IMP |
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RGD |
PMID:18420382 |
RGD:2303631 |
NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
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G |
Dusp10 |
dual specificity phosphatase 10 |
acts_upstream_of |
ISO |
MGI:3052343 (PMID:19696743) |
RGD |
PMID:19696743 |
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NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716
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G |
Map2k6 |
mitogen-activated protein kinase kinase 6 |
involved_in |
ISO |
(PMID:8663524), (PMID:9218798) |
RGD |
PMID:8663524 PMID:9218798 |
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NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293
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G |
Map2k7 |
mitogen activated protein kinase kinase 7 |
involved_in |
IDA IBA IEA ISO |
PMID:10051439 GO_REF:0000033 GO_REF:0000107 (PMID:9535930) |
GO_Central Ensembl RGD |
PMID:9535930 PMID:10051439 |
GO_REF:0000033 GO_REF:0000107, RGD:2298561 |
NCBI chr12:2,591,312...2,600,534
Ensembl chr12:2,591,219...2,604,222
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Map3k13 |
mitogen-activated protein kinase kinase kinase 13 |
involved_in |
ISO |
(PMID:11726277) |
RGD |
PMID:11726277 |
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NCBI chr11:79,094,087...79,235,181
Ensembl chr11:79,097,247...79,235,181
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Map3k20 |
mitogen-activated protein kinase kinase kinase 20 |
involved_in |
ISS ISO |
GO_REF:0000024 (PMID:32289254) (PMID:11836244), (PMID:20559024), (PMID:32289254), (PMID:32610081) |
UniProt RGD |
PMID:11836244 PMID:20559024 PMID:32289254 PMID:32610081 |
GO_REF:0000024 |
NCBI chr 3:57,130,539...57,289,943
Ensembl chr 3:57,130,551...57,289,626
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Map3k5 |
mitogen-activated protein kinase kinase kinase 5 |
involved_in |
ISO |
(PMID:11096076) |
RGD |
PMID:11096076 |
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NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
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Map3k7 |
mitogen activated protein kinase kinase kinase 7 |
involved_in |
ISO |
(PMID:9079627) |
RGD |
PMID:9079627 |
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NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
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Mapk1 |
mitogen activated protein kinase 1 |
involved_in |
ISO IEA |
(PMID:11096076) GO_REF:0000107 |
RGD Ensembl |
PMID:11096076 |
GO_REF:0000107 |
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk11 |
mitogen-activated protein kinase 11 |
involved_in |
ISO |
(PMID:35857590), (PMID:8663524) |
RGD |
PMID:8663524 PMID:35857590 |
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NCBI chr 7:120,218,471...120,225,488
Ensembl chr 7:120,218,478...120,225,395
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G |
Mapk13 |
mitogen activated protein kinase 13 |
involved_in |
ISO ISS IEA |
(PMID:9218798) GO_REF:0000024 GO_REF:0000107 |
RGD UniProt Ensembl |
PMID:9218798 |
GO_REF:0000024 GO_REF:0000107 |
NCBI chr20:6,835,277...6,845,500
Ensembl chr20:6,835,320...6,844,222
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G |
Mapk14 |
mitogen activated protein kinase 14 |
involved_in |
IDA ISO IEA |
(PMID:35857590) GO_REF:0000107 |
RGD Ensembl |
PMID:35857590 PMID:16407200 |
GO_REF:0000107, RGD:1580544 |
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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G |
Mapk3 |
mitogen activated protein kinase 3 |
involved_in |
ISO |
(PMID:11096076) |
RGD |
PMID:11096076 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
involved_in |
ISO IEA |
(PMID:11096076) GO_REF:0000107 |
RGD Ensembl |
PMID:11096076 |
GO_REF:0000107 |
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Nod1 |
nucleotide-binding oligomerization domain containing 1 |
acts_upstream_of |
ISO |
(PMID:18261938) |
RGD |
PMID:18261938 |
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NCBI chr 4:84,060,871...84,111,668
Ensembl chr 4:84,060,880...84,111,404
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G |
Nod2 |
nucleotide-binding oligomerization domain containing 2 |
acts_upstream_of |
ISO |
(PMID:18261938) |
RGD |
PMID:18261938 |
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NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177
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G |
Pbk |
PDZ binding kinase |
acts_upstream_of involved_in |
ISO IBA |
MGI:5293435 (PMID:21715333) GO_REF:0000033 |
RGD GO_Central |
PMID:21715333 |
GO_REF:0000033 |
NCBI chr15:40,022,873...40,034,014
Ensembl chr15:40,023,002...40,034,014
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G |
Ripk2 |
receptor-interacting serine-threonine kinase 2 |
acts_upstream_of |
ISO |
MGI:2446070|MGI:2660793 (PMID:11894097), (PMID:11894098), (PMID:18261938) |
RGD |
PMID:11894097 PMID:11894098 PMID:18261938 |
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NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657
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G |
Taok2 |
TAO kinase 2 |
involved_in |
ISO IEA ISS |
(PMID:11279118) GO_REF:0000107 GO_REF:0000024 |
RGD Ensembl UniProt |
PMID:11279118 |
GO_REF:0000024 GO_REF:0000107 |
NCBI chr 1:181,475,708...181,494,738
Ensembl chr 1:181,475,711...181,494,613
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G |
Tlr4 |
toll-like receptor 4 |
involved_in acts_upstream_of |
IEA ISO |
GO_REF:0000107 (PMID:18261938) |
Ensembl RGD |
PMID:18261938 |
GO_REF:0000107 |
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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Term paths to the root
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