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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of stress-activated protein kinase signaling cascade
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Accession:GO:0070304 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade.
Synonyms:exact_synonym: positive regulation of SAPK signaling pathway;   positive regulation of stress-activated protein kinase signaling pathway;   positive regulation of stress-activated protein kinase signalling pathway;   up regulation of stress-activated protein kinase signaling pathway;   upregulation of stress-activated protein kinase signaling pathway
 narrow_synonym: activation of stress-activated protein kinase signaling pathway;   stimulation of stress-activated protein kinase signaling pathway



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positive regulation of stress-activated protein kinase signaling cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in ISO (PMID:10891478) RGD PMID:10891478 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868
JBrowse link
G Rnf13 ring finger protein 13 involved_in ISS
ISO
GO_REF:0000024
(PMID:23378536)
UniProt
RGD
PMID:23378536 GO_REF:0000024 NCBI chr 2:141,927,887...142,061,801
Ensembl chr 2:141,927,909...142,061,801
JBrowse link
positive regulation of JNK cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor involved_in ISO ComplexPortal:CPX-1134|UniProtKB:P10749 (PMID:20739563) RGD PMID:20739563 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Ankrd6 ankyrin repeat domain 6 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:47,197,981...47,343,183
Ensembl chr 5:47,202,873...47,343,090
JBrowse link
G App amyloid beta precursor protein involved_in ISO ComplexPortal:CPX-1134 (PMID:23921129) RGD PMID:23921129 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Axin1 axin 1 involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
(MGI:3799599|PMID:17681137)
MGI:1856035 (MGI:3797993|PMID:18316368)
UniProt
RGD
PMID:17681137 PMID:18316368 GO_REF:0000024 MGI:3797993 MGI:3799599 NCBI chr10:15,163,684...15,215,615
Ensembl chr10:15,163,684...15,215,615
JBrowse link
G Birc7 baculoviral IAP repeat-containing 7 involved_in ISO (PMID:11865055) RGD PMID:11865055 NCBI chr 3:168,047,824...168,052,606
Ensembl chr 3:168,047,824...168,052,606
JBrowse link
G Card9 caspase recruitment domain family, member 9 acts_upstream_of_or_within ISO MGI:3698412 (MGI:3697751|PMID:17187069)
(PMID:17187069)
RGD PMID:17187069 MGI:3697751 NCBI chr 3:9,171,814...9,180,310
Ensembl chr 3:9,171,815...9,180,237
JBrowse link
G Ccl19 C-C motif chemokine ligand 19 involved_in ISO (PMID:15778365) RGD PMID:15778365 NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308
JBrowse link
G Ccl21 C-C motif chemokine ligand 21 involved_in ISO (PMID:15778365) RGD PMID:15778365 NCBI chr 5:56,980,557...56,981,661
Ensembl chr 5:56,980,558...56,981,686
JBrowse link
G Ccn2 cellular communication network factor 2 involved_in ISO (PMID:20008146) RGD PMID:20008146 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Cd27 CD27 molecule involved_in ISO (MGI:3687722|PMID:9692890) RGD PMID:9692890 MGI:3687722 NCBI chr 4:158,030,700...158,035,862
Ensembl chr 4:158,030,703...158,035,592
JBrowse link
G Cdc42 cell division cycle 42 IDA RGD PMID:17161586 RGD:2298583 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 acts_upstream_of_or_within ISO (MGI:2667426|PMID:12832451) RGD PMID:12832451 MGI:2667426 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992
JBrowse link
G Cracr2a calcium release activated channel regulator 2A involved_in ISO
IBA
(PMID:27016526)
PMID:21873635
(MGI:6141997|PMID:27016526)
RGD PMID:27016526 PMID:21873635 MGI:6141997, RGD:13792537 NCBI chr 4:160,428,987...160,517,427
Ensembl chr 4:160,408,077...160,518,107
JBrowse link
G Crk CRK proto-oncogene, adaptor protein IMP RGD PMID:12198159 RGD:1298803 NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406
JBrowse link
G Dab2 DAB adaptor protein 2 involved_in ISO (MGI:5442512|PMID:15894542) RGD PMID:15894542 MGI:5442512 NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476
JBrowse link
G Dab2ip DAB2 interacting protein involved_in ISS
ISO
GO_REF:0000024
(PMID:17389591), (PMID:19903888)
UniProt
RGD
PMID:17389591 PMID:19903888 GO_REF:0000024 NCBI chr 3:18,915,290...19,086,282
Ensembl chr 3:18,915,290...19,086,280
JBrowse link
G Dixdc1 DIX domain containing 1 IMP RGD PMID:19339625 RGD:2308917 NCBI chr 8:51,007,835...51,081,191
Ensembl chr 8:51,007,838...51,081,090
JBrowse link
G Dusp19 dual specificity phosphatase 19 involved_in ISO (MGI:2182169|PMID:11959862) RGD PMID:11959862 MGI:2182169 NCBI chr 3:65,538,424...65,554,465
Ensembl chr 3:65,538,420...65,553,534
JBrowse link
G Dusp22 dual specificity phosphatase 22 acts_upstream_of_or_within ISO (MGI:2387732|PMID:12138158) RGD PMID:12138158 MGI:2387732 NCBI chr17:33,780,980...33,831,540
Ensembl chr17:33,780,981...33,831,321
JBrowse link
G Eda2r ectodysplasin A2 receptor involved_in IBA
ISO
PMID:21873635
(PMID:12270937)
RGD PMID:12270937 PMID:21873635 RGD:13792537 NCBI chr  X:62,224,763...62,269,344
Ensembl chr  X:62,228,229...62,269,268
JBrowse link
G Edar ectodysplasin-A receptor involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:26,587,836...26,666,543
Ensembl chr20:26,587,839...26,666,494
JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in ISO (PMID:11413129) RGD PMID:11413129 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226
JBrowse link
G Fcgr2b Fc gamma receptor 2B involved_in ISO (MGI:5514474|PMID:23921129) RGD PMID:23921129 MGI:5514474 NCBI chr13:83,191,253...83,207,776
Ensembl chr13:83,193,163...83,207,778
JBrowse link
G Fgd4 FYVE, RhoGEF and PH domain containing 4 IMP RGD PMID:9668039 RGD:1299389 NCBI chr11:84,399,885...84,551,013
Ensembl chr11:84,399,816...84,546,972
JBrowse link
G Fgf19 fibroblast growth factor 19 involved_in ISO (PMID:12815072) RGD PMID:12815072 NCBI chr 1:200,056,656...200,059,944
Ensembl chr 1:200,056,644...200,060,287
JBrowse link
G Flt4 Fms related receptor tyrosine kinase 4 involved_in ISO
IEA
(PMID:16076871)
GO_REF:0000107
RGD
Ensembl
PMID:16076871 GO_REF:0000107 NCBI chr10:33,913,725...33,954,770
Ensembl chr10:33,913,608...33,954,770
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha involved_in ISO
IEA
(PMID:9827804)
GO_REF:0000107
RGD
Ensembl
PMID:9827804 GO_REF:0000107 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta involved_in ISO (PMID:9827804) RGD PMID:9827804 NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma involved_in ISO (PMID:9827804) RGD PMID:9827804 NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610
JBrowse link
G Hipk2 homeodomain interacting protein kinase 2 involved_in ISO (PMID:14678985) RGD PMID:14678985 NCBI chr 4:67,439,327...67,619,223
Ensembl chr 4:67,440,501...67,619,223
JBrowse link
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:12765338) RGD PMID:12765338 NCBI chr12:5,973,062...5,978,565
Ensembl chr12:5,901,586...5,978,565
JBrowse link
G Hras HRas proto-oncogene, GTPase involved_in ISO (PMID:22065586) RGD PMID:22065586 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Il1a interleukin 1 alpha IDA RGD PMID:15671867 RGD:1358666 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta acts_upstream_of_or_within
involved_in
IDA
ISO
MGI:1346877 (MGI:3607973|PMID:16260493)
ComplexPortal:CPX-1134|UniProtKB:Q15109 (MGI:5902681|PMID:20739563)
RGD PMID:16260493 PMID:20739563 PMID:15671867 MGI:3607973 MGI:5902681, RGD:1358666 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il3 interleukin 3 acts_upstream_of_or_within ISO (MGI:3032484|PMID:14967141) RGD PMID:14967141 MGI:3032484 NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066
JBrowse link
G Ltbr lymphotoxin beta receptor involved_in ISO (PMID:20732415) RGD PMID:20732415 NCBI chr 4:158,108,884...158,115,339
Ensembl chr 4:158,108,886...158,121,539
JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 IDA RGD PMID:17064355 RGD:2298577 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993
JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 involved_in IDA
ISO
(MGI:1101248|PMID:9405446) RGD PMID:9405446 PMID:10051439 PMID:17064355 PMID:11849756 MGI:1101248, RGD:2298561, RGD:2298577, RGD:2298565 NCBI chr12:2,591,312...2,604,211
Ensembl chr12:2,591,219...2,604,222
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 IDA RGD PMID:9110999 RGD:2293488 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463
JBrowse link
G Map3k10 mitogen activated protein kinase kinase kinase 10 involved_in ISO (PMID:17584736) RGD PMID:17584736 NCBI chr 1:82,955,783...82,974,084
Ensembl chr 1:82,955,207...82,974,084
JBrowse link
G Map3k11 mitogen-activated protein kinase kinase kinase 11 involved_in IDA
ISO
(PMID:17584736) RGD PMID:17584736 PMID:17064355 RGD:2298577 NCBI chr 1:202,975,353...202,988,655
Ensembl chr 1:202,975,353...202,988,652
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 involved_in ISO (MGI:5616327|PMID:12050113) RGD PMID:12050113 MGI:5616327 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 acts_upstream_of_or_within ISO MGI:104798|MGI:96536|MGI:96824 (MGI:3607973|PMID:16260493) RGD PMID:16260493 MGI:3607973 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
JBrowse link
G Map4k2 mitogen activated protein kinase kinase kinase kinase 2 involved_in ISO (PMID:17584736) RGD PMID:17584736 NCBI chr 1:203,645,098...203,660,515
Ensembl chr 1:203,645,153...203,660,331
JBrowse link
G Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 involved_in ISO (MGI:86683|PMID:9135144) RGD PMID:9135144 MGI:86683 NCBI chr 9:42,200,708...42,326,708
Ensembl chr 9:42,200,278...42,326,698
JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:5546548|PMID:23963642)
UniProt
RGD
PMID:23963642 GO_REF:0000024 MGI:5546548 NCBI chr 3:78,355,051...78,372,946
Ensembl chr 3:78,355,048...78,372,884
JBrowse link
G Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 involved_in IMP PMID:21076496 UniProt PMID:21076496 RGD:13673827 NCBI chr10:13,918,417...13,958,335
Ensembl chr10:13,918,400...13,958,273
JBrowse link
G Mapkbp1 mitogen activated protein kinase binding protein 1 acts_upstream_of_or_within
involved_in
ISO
IBA
(MGI:1344829|PMID:10471813)
PMID:21873635
RGD PMID:10471813 PMID:21873635 MGI:1344829, RGD:13792537 NCBI chr 3:106,947,342...106,998,368
Ensembl chr 3:106,947,827...106,996,199
JBrowse link
G Mbip MAP3K12 binding inhibitory protein 1 involved_in ISO (PMID:10801814), (PMID:32963352) RGD PMID:10801814 PMID:32963352 NCBI chr 6:73,808,133...73,825,394
Ensembl chr 6:73,808,133...73,825,374
JBrowse link
G Mfhas1 multifunctional ROCO family signaling regulator 1 involved_in ISO (PMID:28471450) RGD PMID:28471450 NCBI chr16:56,545,462...56,633,649
Ensembl chr16:56,546,207...56,633,743
JBrowse link
G Mink1 misshapen-like kinase 1 involved_in ISO
IEA
(PMID:15469942)
(MGI:1354211|PMID:10708748)
GO_REF:0000107
RGD
Ensembl
PMID:10708748 PMID:15469942 GO_REF:0000107 MGI:1354211 NCBI chr10:55,278,293...55,330,782
Ensembl chr10:55,278,391...55,330,782
JBrowse link
G Mmp8 matrix metallopeptidase 8 involved_in IEA
ISO
GO_REF:0000107
(MGI:6201889|PMID:25049354)
Ensembl
RGD
PMID:25049354 GO_REF:0000107 MGI:6201889 NCBI chr 8:4,724,009...4,732,956
Ensembl chr 8:4,724,029...4,733,520
JBrowse link
G Mturn maturin, neural progenitor differentiation regulator homolog involved_in ISO (PMID:24681962) RGD PMID:24681962 NCBI chr 4:83,807,528...83,828,494
Ensembl chr 4:83,807,579...83,824,950
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor acts_upstream_of_or_within ISO MGI:2385681 (MGI:2669022|PMID:12855817) RGD PMID:12855817 MGI:2669022 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 involved_in ISO (PMID:11865055) RGD PMID:11865055 NCBI chr 2:31,507,423...31,559,098
Ensembl chr 2:31,507,424...31,570,542
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 involved_in ISO (PMID:26514923) RGD PMID:26514923 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
JBrowse link
G Nod1 nucleotide-binding oligomerization domain containing 1 acts_upstream_of_or_within ISO (MGI:3775161|PMID:18261938) RGD PMID:18261938 MGI:3775161 NCBI chr 4:84,060,871...84,111,668
Ensembl chr 4:84,060,880...84,111,404
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 acts_upstream_of_or_within ISO (MGI:3775161|PMID:18261938)
(PMID:17187069)
RGD PMID:17187069 PMID:18261938 MGI:3775161 NCBI chr19:18,379,720...18,422,817
Ensembl chr19:18,382,439...18,417,177
JBrowse link
G Nox1 NADPH oxidase 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3616995 (MGI:4881403|PMID:19661248)
Ensembl
RGD
PMID:19661248 GO_REF:0000107 MGI:4881403 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236
JBrowse link
G Nrk Nik related kinase acts_upstream_of_or_within ISO (MGI:1860727|PMID:10801798) RGD PMID:10801798 MGI:1860727 NCBI chr  X:102,365,747...102,462,957
Ensembl chr  X:102,365,765...102,459,657
JBrowse link
G Pja2 praja ring finger ubiquitin ligase 2 involved_in ISO
ISS
(PMID:28471450)
GO_REF:0000024
RGD
UniProt
PMID:28471450 GO_REF:0000024 NCBI chr 9:103,956,678...104,006,763
Ensembl chr 9:103,956,678...104,006,783
JBrowse link
G Plcb1 phospholipase C beta 1 involved_in ISO
IEA
(PMID:9500449)
GO_REF:0000107
RGD
Ensembl
PMID:9500449 GO_REF:0000107 NCBI chr 3:122,059,968...122,772,896
Ensembl chr 3:122,060,031...122,772,869
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta involved_in ISS
ISO
GO_REF:0000024
(PMID:8670418)
UniProt
RGD
PMID:8670418 GO_REF:0000024 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282
JBrowse link
G Pycard PYD and CARD domain containing involved_in ISO (PMID:21487011) RGD PMID:21487011 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 involved_in ISO (PMID:19933860) RGD PMID:19933860 NCBI chr 3:104,168,549...104,230,107
Ensembl chr 3:104,170,013...104,230,056
JBrowse link
G Rassf2 Ras association domain family member 2 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(PMID:19962960)
RGD PMID:19962960 PMID:21873635 RGD:13792537 NCBI chr 3:119,244,288...119,280,462
Ensembl chr 3:119,245,821...119,280,431
JBrowse link
G Rb1cc1 RB1-inducible coiled-coil 1 acts_upstream_of_or_within ISO MGI:104798 (MGI:3689241|PMID:17015619) RGD PMID:17015619 MGI:3689241 NCBI chr 5:13,161,648...13,225,560
Ensembl chr 5:13,161,648...13,225,560
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in ISO (PMID:17389591)
(MGI:5306563|PMID:20125124)
RGD PMID:17389591 PMID:20125124 MGI:5306563 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 acts_upstream_of_or_within ISO MGI:2446070|MGI:2660793 (MGI:2176422|PMID:11894098), (MGI:2176424|PMID:11894097), (MGI:3775161|PMID:18261938) RGD PMID:11894097 PMID:11894098 PMID:18261938 MGI:2176422 MGI:2176424 MGI:3775161 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657
JBrowse link
G Serpinf2 serpin family F member 2 involved_in ISO (PMID:20008146) RGD PMID:20008146 NCBI chr10:60,272,400...60,280,506
Ensembl chr10:60,272,400...60,281,243
JBrowse link
G Sh3rf1 SH3 domain containing ring finger 1 involved_in ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(MGI:5546548|PMID:23963642), (MGI:6158776|PMID:27084103)
UniProt
RGD
PMID:23963642 PMID:27084103 PMID:21873635 GO_REF:0000024 MGI:5546548 MGI:6158776, RGD:13792537 NCBI chr16:28,735,522...28,901,690
Ensembl chr16:28,735,440...28,901,644
JBrowse link
G Sh3rf2 SH3 domain containing ring finger 2 involved_in ISO
IBA
ISS
(PMID:24130170)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:24130170 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr18:34,045,715...34,148,342
Ensembl chr18:34,046,879...34,146,856
JBrowse link
G Sh3rf3 SH3 domain containing ring finger 3 involved_in ISO
IBA
(PMID:20696164)
PMID:21873635
RGD PMID:20696164 PMID:21873635 RGD:13792537 NCBI chr20:26,765,278...27,099,261
Ensembl chr20:26,765,015...27,099,257
JBrowse link
G Slamf1 signaling lymphocytic activation molecule family member 1 involved_in ISO (PMID:20231852) RGD PMID:20231852 NCBI chr13:84,270,316...84,305,497
Ensembl chr13:84,270,316...84,305,497
JBrowse link
G Stk3 serine/threonine kinase 3 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:104798|MGI:1929004 (MGI:4420852|PMID:20080598)
Ensembl
RGD
PMID:20080598 GO_REF:0000107 MGI:4420852 NCBI chr 7:66,053,209...66,323,292
Ensembl chr 7:66,052,345...66,323,233
JBrowse link
G Taok1 TAO kinase 1 involved_in ISO
IEA
ISS
(PMID:16407310)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:16407310 GO_REF:0000024 GO_REF:0000107 NCBI chr10:62,373,076...62,465,295
Ensembl chr10:62,381,404...62,465,766
JBrowse link
G Taok2 TAO kinase 2 involved_in IEA
ISO
GO_REF:0000107
(MGI:5462161|PMID:22683681)
(PMID:10660600)
Ensembl
RGD
PMID:10660600 PMID:22683681 GO_REF:0000107 MGI:5462161 NCBI chr 1:181,475,708...181,494,738
Ensembl chr 1:181,475,711...181,494,613
JBrowse link
G Taok3 TAO kinase 3 involved_in ISO
IEA
(PMID:10924369)
GO_REF:0000107
RGD
Ensembl
PMID:10924369 GO_REF:0000107 NCBI chr12:39,314,027...39,394,243
Ensembl chr12:39,314,027...39,461,244
JBrowse link
G Tirap TIR domain containing adaptor protein involved_in ISO (PMID:11544529) RGD PMID:11544529 NCBI chr 8:33,531,724...33,548,508
Ensembl chr 8:33,531,725...33,547,432
JBrowse link
G Tlr3 toll-like receptor 3 acts_upstream_of_or_within ISO (MGI:3607973|PMID:16260493) RGD PMID:16260493 MGI:3607973 NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545
JBrowse link
G Tlr4 toll-like receptor 4 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1346877 (MGI:3607973|PMID:16260493), (MGI:3775161|PMID:18261938)
Ensembl
RGD
PMID:16260493 PMID:18261938 GO_REF:0000107 MGI:3607973 MGI:3775161 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor acts_upstream_of_or_within ISO MGI:1346877 (MGI:3607973|PMID:16260493), (MGI:4420852|PMID:20080598) RGD PMID:16260493 PMID:20080598 MGI:3607973 MGI:4420852 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf19 TNF receptor superfamily member 19 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:35,092,206...35,158,472
Ensembl chr15:35,092,206...35,180,795
JBrowse link
G Tnfsf11 TNF superfamily member 11 acts_upstream_of_or_within
involved_in
ISO
IEA
MGI:109520 (MGI:5308511|PMID:22073305)
GO_REF:0000107
RGD
Ensembl
PMID:22073305 GO_REF:0000107 MGI:5308511 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Tnik TRAF2 and NCK interacting kinase involved_in ISO (PMID:10521462), (PMID:15342639) RGD PMID:10521462 PMID:15342639 NCBI chr 2:111,184,352...111,587,993
Ensembl chr 2:111,184,387...111,580,750
JBrowse link
G Tpd52l1 TPD52 like 1 involved_in ISO (PMID:14761963) RGD PMID:14761963 NCBI chr 1:26,172,038...26,290,704
Ensembl chr 1:26,172,170...26,291,109
JBrowse link
G Traf1 TNF receptor-associated factor 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807
JBrowse link
G Traf2 Tnf receptor-associated factor 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538
JBrowse link
G Traf3 Tnf receptor-associated factor 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:130,199,696...130,307,168
Ensembl chr 6:130,206,484...130,305,481
JBrowse link
G Traf4 Tnf receptor associated factor 4 involved_in IBA
ISO
PMID:21873635
(PMID:16157600)
RGD PMID:16157600 PMID:21873635 RGD:13792537 NCBI chr10:63,054,169...63,060,284
Ensembl chr10:63,054,181...63,060,284
JBrowse link
G Traf5 TNF receptor-associated factor 5 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:103,569,944...103,618,756
Ensembl chr13:103,572,314...103,618,709
JBrowse link
G Traf6 TNF receptor associated factor 6 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507
JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 involved_in ISO (MGI:5440106|PMID:23021218) RGD PMID:23021218 MGI:5440106 NCBI chr12:41,938,533...41,977,517
Ensembl chr12:41,938,560...41,977,517
JBrowse link
G Unc5cl unc-5 family C-terminal like involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(PMID:22158417)
RGD PMID:22158417 PMID:21873635 RGD:13792537 NCBI chr 9:12,528,109...12,543,382
Ensembl chr 9:12,528,246...12,542,233
JBrowse link
G Wnt16 Wnt family member 16 involved_in ISO (PMID:17200136) RGD PMID:17200136 NCBI chr 4:50,820,968...50,831,380
Ensembl chr 4:50,820,968...50,831,380
JBrowse link
G Wnt5a Wnt family member 5A acts_upstream_of ISO (MGI:4820702|PMID:20032469) RGD PMID:20032469 MGI:4820702 NCBI chr16:3,695,667...3,718,234
Ensembl chr16:3,697,032...3,718,234
JBrowse link
G Wnt7a Wnt family member 7A involved_in IMP
IBA
PMID:21873635 RGD
GO_Central
PMID:18567805 PMID:21873635 RGD:4107045, RGD:13792537 NCBI chr 4:123,863,108...123,908,981
Ensembl chr 4:123,863,108...123,908,981
JBrowse link
G Wnt7b Wnt family member 7B involved_in IDA
IBA
IMP
PMID:21873635 RGD
GO_Central
PMID:18177422 PMID:21873635 PMID:18177422 RGD:2292645, RGD:13792537, RGD:2292645 NCBI chr 7:116,634,817...116,679,089
Ensembl chr 7:116,634,814...116,679,581
JBrowse link
G Xiap X-linked inhibitor of apoptosis involved_in ISO (PMID:11865055) RGD PMID:11865055 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
G Zfp622 zinc finger protein 622 involved_in ISO (PMID:21771788) RGD PMID:21771788 NCBI chr 2:76,479,605...76,494,405
Ensembl chr 2:76,335,609...76,493,898
JBrowse link
positive regulation of p38MAPK cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor involved_in ISO ComplexPortal:CPX-1134|UniProtKB:P10749 (PMID:20739563) RGD PMID:20739563 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 involved_in ISO (PMID:23389627) RGD PMID:23389627 NCBI chr 2:174,061,126...174,118,355
Ensembl chr 2:174,062,976...174,118,355
JBrowse link
G Bmp2 bone morphogenetic protein 2 involved_in IEA
ISO
GO_REF:0000107
(PMID:22540193)
Ensembl
RGD
PMID:22540193 GO_REF:0000107 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Bmp4 bone morphogenetic protein 4 involved_in ISO
IEA
(PMID:17600318)
GO_REF:0000107
RGD
Ensembl
PMID:17600318 GO_REF:0000107 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 IDA RGD PMID:18584881 RGD:2303073 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
JBrowse link
G Emc10 ER membrane protein complex subunit 10 involved_in ISS
ISO
GO_REF:0000024
(MGI:6163930|PMID:28931551)
UniProt
RGD
PMID:28931551 GO_REF:0000024 MGI:6163930 NCBI chr 1:94,980,260...94,988,847
Ensembl chr 1:94,943,587...94,988,847
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha involved_in ISO
IEA
(PMID:9827804)
GO_REF:0000107
RGD
Ensembl
PMID:9827804 GO_REF:0000107 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta involved_in ISO (PMID:9827804) RGD PMID:9827804 NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma involved_in ISO (PMID:9827804) RGD PMID:9827804 NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610
JBrowse link
G Gdf6 growth differentiation factor 6 involved_in ISS
ISO
GO_REF:0000024
(MGI:5751611|PMID:26774823)
UniProt
RGD
PMID:26774823 GO_REF:0000024 MGI:5751611 NCBI chr 5:22,996,246...23,012,567
Ensembl chr 5:22,996,246...23,012,567
JBrowse link
G Hand2 heart and neural crest derivatives expressed 2 involved_in IEA
ISO
GO_REF:0000107
(PMID:24161931)
Ensembl
RGD
PMID:24161931 GO_REF:0000107 NCBI chr16:32,917,826...32,919,880
Ensembl chr16:32,917,823...32,919,891
JBrowse link
G Il1b interleukin 1 beta involved_in ISO ComplexPortal:CPX-1134|UniProtKB:Q15109 (MGI:5902681|PMID:20739563) RGD PMID:20739563 MGI:5902681 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Lep leptin involved_in ISS
ISO
IBA
GO_REF:0000024
(PMID:24340098)
PMID:21873635
UniProt
RGD
PMID:24340098 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Map3k3 mitogen activated protein kinase kinase kinase 3 acts_upstream_of_or_within ISO (MGI:1353859|PMID:10700190) RGD PMID:10700190 MGI:1353859 NCBI chr10:91,020,174...91,088,852
Ensembl chr10:91,020,174...91,088,848
JBrowse link
G Map3k4 mitogen activated protein kinase kinase kinase 4 involved_in ISO (PMID:9305639) RGD PMID:9305639 NCBI chr 1:48,431,801...48,519,358
Ensembl chr 1:48,431,830...48,519,358
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 IMP RGD PMID:20716917 RGD:10412640 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase acts_upstream_of_or_within ISO MGI:3041135 (MGI:5529574|PMID:23994610) RGD PMID:23994610 MGI:5529574 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Mfhas1 multifunctional ROCO family signaling regulator 1 involved_in ISO (PMID:28471450) RGD PMID:28471450 NCBI chr16:56,545,462...56,633,649
Ensembl chr16:56,546,207...56,633,743
JBrowse link
G Mink1 misshapen-like kinase 1 involved_in ISO (MGI:1354211|PMID:10708748) RGD PMID:10708748 MGI:1354211 NCBI chr10:55,278,293...55,330,782
Ensembl chr10:55,278,391...55,330,782
JBrowse link
G Mir181a2 microRNA 181a-2 involved_in ISO (PMID:23993976) RGD PMID:23993976 NCBI chr 3:22,615,845...22,615,961
Ensembl chr 3:22,615,845...22,615,961
JBrowse link
G Mir181b1 microRNA 181b-1 involved_in ISO (PMID:23993976) RGD PMID:23993976 NCBI chr13:49,485,688...49,485,797
Ensembl chr13:49,485,688...49,485,797
JBrowse link
G Mir181b2 microRNA 181b-2 involved_in ISO (PMID:23993976) RGD PMID:23993976 NCBI chr 3:22,616,948...22,617,035
Ensembl chr 3:22,616,948...22,617,035
JBrowse link
G Mir181d microRNA 181d involved_in ISO (PMID:23993976) RGD PMID:23993976 NCBI chr19:23,983,706...23,983,788
Ensembl chr19:23,983,706...23,983,788
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 involved_in ISO (PMID:26514923) RGD PMID:26514923 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
JBrowse link
G Oprk1 opioid receptor, kappa 1 IDA RGD PMID:16648139 RGD:9831415 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Pja2 praja ring finger ubiquitin ligase 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:28471450)
UniProt
RGD
PMID:28471450 GO_REF:0000024 NCBI chr 9:103,956,678...104,006,763
Ensembl chr 9:103,956,678...104,006,783
JBrowse link
G Prmt1 protein arginine methyltransferase 1 involved_in IDA PMID:23483889 BHF-UCL PMID:23483889 RGD:10047341 NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345
JBrowse link
G Rell1 RELT-like 1 involved_in IBA
ISO
PMID:21873635
(PMID:28688764)
RGD PMID:28688764 PMID:21873635 RGD:13792537 NCBI chr14:44,318,640...44,378,541
Ensembl chr14:44,303,009...44,378,500
JBrowse link
G Rell2 RELT-like 2 involved_in IBA
ISS
ISO
PMID:21873635
GO_REF:0000024
(PMID:28688764)
UniProt
RGD
PMID:28688764 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr18:29,789,996...29,793,986
Ensembl chr18:29,790,415...29,793,986
JBrowse link
G Sash1 SAM and SH3 domain containing 1 acts_upstream_of_or_within ISO (PMID:23776175) RGD PMID:23776175 NCBI chr 1:3,119,915...3,418,536
Ensembl chr 1:3,121,332...3,439,870
JBrowse link
G Sphk1 sphingosine kinase 1 involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:23935096)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:23935096 GO_REF:0000024 GO_REF:0000107 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
JBrowse link
G Spi1 Spi-1 proto-oncogene involved_in ISO (MGI:6478061|PMID:28912174) RGD PMID:28912174 MGI:6478061 NCBI chr 3:77,059,744...77,093,730
Ensembl chr 3:77,073,012...77,092,393
JBrowse link
G Stk39 serine threonine kinase 39 involved_in ISO
IMP
(PMID:10980603) RGD PMID:10980603 PMID:10980603 RGD:727300 NCBI chr 3:52,913,583...53,179,060
Ensembl chr 3:52,913,585...53,179,060
JBrowse link
G Vegfa vascular endothelial growth factor A involved_in ISO (PMID:18386220) RGD PMID:18386220 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Xdh xanthine dehydrogenase involved_in ISO
IEA
(PMID:18386220)
GO_REF:0000107
RGD
Ensembl
PMID:18386220 GO_REF:0000107 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A involved_in ISO (PMID:24048733) RGD PMID:24048733 NCBI chr 5:137,376,562...137,385,351
Ensembl chr 5:137,376,564...137,385,351
JBrowse link
positive regulation of stress-activated MAPK cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arl6ip5 ADP-ribosylation factor like GTPase 6 interacting protein 5 involved_in IEA
ISO
GO_REF:0000107
(PMID:18387645)
Ensembl
RGD
PMID:18387645 GO_REF:0000107 NCBI chr 4:129,810,650...129,838,628
Ensembl chr 4:129,810,645...129,838,608
JBrowse link
G Card9 caspase recruitment domain family, member 9 acts_upstream_of_or_within
involved_in
ISO
ISS
MGI:3698412 (MGI:3697751|PMID:17187069)
(MGI:6117948|PMID:29080677)
(PMID:17187069)
GO_REF:0000024
RGD
UniProt
PMID:17187069 PMID:29080677 GO_REF:0000024 MGI:3697751 MGI:6117948 NCBI chr 3:9,171,814...9,180,310
Ensembl chr 3:9,171,815...9,180,237
JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 IMP RGD PMID:19211730 RGD:5130956 NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:5487533|PMID:20038207)
UniProt
RGD
PMID:20038207 GO_REF:0000024 MGI:5487533 NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase IMP RGD PMID:17161379 RGD:5508698 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Igfbp6 insulin-like growth factor binding protein 6 involved_in ISO (PMID:24003225) RGD PMID:24003225 NCBI chr 7:133,276,309...133,280,944
Ensembl chr 7:133,276,234...133,280,966
JBrowse link
G Il1a interleukin 1 alpha IDA RGD PMID:15671867 RGD:1358666 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta IMP
IDA
RGD PMID:12629164 PMID:15671867 RGD:1626685, RGD:1358666 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Inava innate immunity activator involved_in ISO (PMID:28436939) RGD PMID:28436939 NCBI chr13:47,666,446...47,687,383
Ensembl chr13:47,666,447...47,686,729
JBrowse link
G Kiss1 KiSS-1 metastasis-suppressor NOT IMP RGD PMID:16222076 RGD:1599289 NCBI chr13:44,774,823...44,780,707
Ensembl chr13:44,774,823...44,780,612
JBrowse link
G Klhdc10 kelch domain containing 10 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:59,021,300...59,079,118
Ensembl chr 4:59,021,310...59,074,941
JBrowse link
G Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 IMP RGD PMID:12024021 RGD:2302280 NCBI chr 7:120,526,732...120,536,982
Ensembl chr 7:120,526,732...120,536,982
JBrowse link
G Mid1 midline 1 involved_in ISO (PMID:17438131) RGD PMID:17438131 NCBI chr  X:24,116,674...24,491,205
Ensembl chr  X:24,120,293...24,248,353
JBrowse link
G Nod1 nucleotide-binding oligomerization domain containing 1 acts_upstream_of_or_within ISO (MGI:3775161|PMID:18261938) RGD PMID:18261938 MGI:3775161 NCBI chr 4:84,060,871...84,111,668
Ensembl chr 4:84,060,880...84,111,404
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 acts_upstream_of_or_within ISO (MGI:3775161|PMID:18261938)
(PMID:17187069)
RGD PMID:17187069 PMID:18261938 MGI:3775161 NCBI chr19:18,379,720...18,422,817
Ensembl chr19:18,382,439...18,417,177
JBrowse link
G Pdcd10 programmed cell death 10 involved_in ISO (PMID:22652780) RGD PMID:22652780 NCBI chr 2:160,303,465...160,346,086
Ensembl chr 2:160,303,449...160,346,018
JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 acts_upstream_of_or_within ISO MGI:2446070|MGI:2660793 (MGI:2176422|PMID:11894098), (MGI:2176424|PMID:11894097), (MGI:3775161|PMID:18261938) RGD PMID:11894097 PMID:11894098 PMID:18261938 MGI:2176422 MGI:2176424 MGI:3775161 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657
JBrowse link
G Scimp SLP adaptor and CSK interacting membrane protein involved_in ISO (MGI:5803730|PMID:27288407) RGD PMID:27288407 MGI:5803730 NCBI chr10:55,507,593...55,528,288
Ensembl chr10:55,507,519...55,528,171
JBrowse link
G Sema4c semaphorin 4C involved_in ISO (PMID:17498836) RGD PMID:17498836 NCBI chr 9:38,791,668...38,802,171
Ensembl chr 9:38,791,670...38,802,128
JBrowse link
G Stk25 serine/threonine kinase 25 involved_in ISO (PMID:22652780) RGD PMID:22652780 NCBI chr 9:94,161,834...94,174,095
Ensembl chr 9:94,161,836...94,174,244
JBrowse link
G Taok1 TAO kinase 1 involved_in ISO
ISS
(PMID:17396146)
GO_REF:0000024
RGD
UniProt
PMID:17396146 GO_REF:0000024 NCBI chr10:62,373,076...62,465,295
Ensembl chr10:62,381,404...62,465,766
JBrowse link
G Taok2 TAO kinase 2 involved_in ISO
ISS
(PMID:17396146)
GO_REF:0000024
RGD
UniProt
PMID:17396146 GO_REF:0000024 NCBI chr 1:181,475,708...181,494,738
Ensembl chr 1:181,475,711...181,494,613
JBrowse link
G Taok3 TAO kinase 3 involved_in ISS
ISO
GO_REF:0000024
(PMID:17396146)
UniProt
RGD
PMID:17396146 GO_REF:0000024 NCBI chr12:39,314,027...39,394,243
Ensembl chr12:39,314,027...39,461,244
JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:17192487)
UniProt
RGD
PMID:17192487 GO_REF:0000024 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Tlr4 toll-like receptor 4 acts_upstream_of_or_within ISO (MGI:3775161|PMID:18261938) RGD PMID:18261938 MGI:3775161 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18877
    response to stimulus 10238
      response to stress 4164
        cellular response to stress 2102
          stress-activated protein kinase signaling cascade 265
            positive regulation of stress-activated protein kinase signaling cascade 143
              positive regulation of stress-activated MAPK cascade + 141
Path 2
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  biological_process 18877
    biological regulation 13380
      regulation of biological process 12644
        regulation of cellular process 11961
          signal transduction 6838
            intracellular signal transduction 2675
              stress-activated protein kinase signaling cascade 265
                regulation of stress-activated protein kinase signaling cascade 217
                  positive regulation of stress-activated protein kinase signaling cascade 143
                    positive regulation of stress-activated MAPK cascade + 141
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