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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
decreases activity |
ISO |
demethoxycurcumin results in decreased activity of ABCC1 protein |
CTD |
PMID:15885658 PMID:16021489 |
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NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
decreases activity |
ISO |
demethoxycurcumin results in decreased activity of ABCC2 protein |
CTD |
PMID:15885658 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Ache |
acetylcholinesterase |
decreases activity |
EXP |
demethoxycurcumin results in decreased activity of ACHE protein |
CTD |
PMID:18930076 |
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NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Akt1 |
AKT serine/threonine kinase 1 |
increases phosphorylation multiple interactions |
ISO |
demethoxycurcumin results in increased phosphorylation of AKT1 protein AKT1 protein affects the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA] [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of AKT1 protein]; demethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:17535857 PMID:35752269 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
App |
amyloid beta precursor protein |
multiple interactions decreases secretion |
ISO |
demethoxycurcumin inhibits the reaction [APP protein binds to APP protein] demethoxycurcumin results in decreased secretion of APP protein |
CTD |
PMID:19715544 |
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NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Atf6 |
activating transcription factor 6 |
multiple interactions |
ISO |
demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased expression of ATF6 protein] |
CTD |
PMID:26264395 |
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NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
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G |
Bak1 |
BCL2-antagonist/killer 1 |
decreases expression |
ISO |
demethoxycurcumin results in decreased expression of BAK1 mRNA |
CTD |
PMID:33582110 |
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NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
demethoxycurcumin results in increased expression of BAX protein |
CTD |
PMID:34291863 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
demethoxycurcumin results in decreased expression of BCL2 protein |
CTD |
PMID:34291863 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression |
ISO |
demethoxycurcumin results in decreased expression of BCL2L1 mRNA; demethoxycurcumin results in decreased expression of BCL2L1 protein |
CTD |
PMID:33582110 PMID:34291863 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
decreases expression |
ISO |
demethoxycurcumin results in decreased expression of BIRC5 protein |
CTD |
PMID:34291863 |
|
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Casp12 |
caspase 12 |
multiple interactions |
ISO |
demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased expression of CASP12 protein modified form] |
CTD |
PMID:26264395 |
|
NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
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G |
Casp3 |
caspase 3 |
multiple interactions decreases expression increases cleavage |
ISO |
demethoxycurcumin inhibits the reaction [Peroxynitrous Acid results in increased activity of CASP3 protein] demethoxycurcumin results in decreased expression of CASP3 mRNA demethoxycurcumin results in increased cleavage of CASP3 protein |
CTD |
PMID:19188863 PMID:33582110 PMID:34291863 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
decreases expression |
ISO |
demethoxycurcumin results in decreased expression of CASP8 mRNA |
CTD |
PMID:33582110 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
increases activity decreases expression increases cleavage |
ISO |
demethoxycurcumin results in increased activity of CASP9 protein demethoxycurcumin results in decreased expression of CASP9 mRNA demethoxycurcumin results in increased cleavage of CASP9 protein |
CTD |
PMID:33582110 PMID:34291863 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cd36 |
CD36 molecule |
multiple interactions |
ISO |
demethoxycurcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CD36 mRNA]; demethoxycurcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 mRNA]; demethoxycurcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 protein] |
CTD |
PMID:23386263 |
|
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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G |
Cdk4 |
cyclin-dependent kinase 4 |
decreases expression |
ISO |
demethoxycurcumin results in decreased expression of CDK4 protein |
CTD |
PMID:34291863 |
|
NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
demethoxycurcumin results in increased expression of CDKN1A mRNA |
CTD |
PMID:33582110 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions |
ISO |
demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein] |
CTD |
PMID:26264395 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions |
ISO |
demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2AK3 protein] |
CTD |
PMID:26264395 |
|
NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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G |
Erbb2 |
erb-b2 receptor tyrosine kinase 2 |
increases response to substance multiple interactions |
ISO |
ERBB2 protein results in increased susceptibility to demethoxycurcumin benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [demethoxycurcumin results in increased degradation of ERBB2 protein]; demethoxycurcumin results in decreased expression of and results in increased degradation of ERBB2 protein |
CTD |
PMID:34291863 |
|
NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
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G |
Ern1 |
endoplasmic reticulum to nucleus signaling 1 |
multiple interactions |
ISO |
demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased phosphorylation of ERN1 protein] |
CTD |
PMID:26264395 |
|
NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
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G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
increases expression |
ISO |
demethoxycurcumin results in increased expression of GADD45A mRNA |
CTD |
PMID:33582110 |
|
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
increases expression |
ISO |
demethoxycurcumin results in increased expression of GCLM mRNA demethoxycurcumin results in increased expression of GCLM mRNA; demethoxycurcumin results in increased expression of GCLM protein |
CTD |
PMID:17535857 PMID:19188863 PMID:23386263 |
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NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions increases expression |
ISO |
[demethoxycurcumin co-treated with bisdemethoxycurcumin] results in increased expression of HMOX1 mRNA; AKT1 protein affects the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA]; KEAP1 protein inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA]; PRKCD protein affects the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA]; rottlerin inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA]; rottlerin inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 protein] demethoxycurcumin results in increased expression of HMOX1 mRNA; demethoxycurcumin results in increased expression of HMOX1 protein demethoxycurcumin promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of HMOX1 mRNA] |
CTD |
PMID:17535857 PMID:19188863 PMID:23386263 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions |
ISO |
demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein] |
CTD |
PMID:26264395 |
|
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Ins2 |
insulin 2 |
increases secretion |
ISO |
demethoxycurcumin results in increased secretion of INS protein |
CTD |
PMID:19188863 |
|
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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G |
Kdr |
kinase insert domain receptor |
affects expression multiple interactions |
ISO |
demethoxycurcumin affects the expression of KDR mRNA [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]; demethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein] |
CTD |
PMID:17960570 PMID:35752269 |
|
NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
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G |
Keap1 |
Kelch-like ECH-associated protein 1 |
multiple interactions |
ISO |
KEAP1 protein inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA] |
CTD |
PMID:17535857 |
|
NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases phosphorylation multiple interactions |
ISO |
demethoxycurcumin results in increased phosphorylation of MAPK1 protein [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; demethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:17535857 PMID:35752269 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation multiple interactions |
ISO |
demethoxycurcumin results in increased phosphorylation of MAPK3 protein [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]; demethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:17535857 PMID:35752269 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mmp14 |
matrix metallopeptidase 14 |
decreases expression |
ISO |
demethoxycurcumin results in decreased expression of MMP14 protein |
CTD |
PMID:18495463 |
|
NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
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G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions |
ISO |
demethoxycurcumin results in decreased secretion of and results in decreased activity of MMP2 protein modified form |
CTD |
PMID:18495463 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions |
ISO |
demethoxycurcumin results in decreased secretion of and results in decreased activity of MMP9 protein |
CTD |
PMID:18495463 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Msr1 |
macrophage scavenger receptor 1 |
multiple interactions |
ISO |
demethoxycurcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA] |
CTD |
PMID:23386263 |
|
NCBI chr16:52,717,775...52,803,602
Ensembl chr16:52,717,732...52,799,676
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
affects localization multiple interactions |
ISO |
demethoxycurcumin affects the localization of NFE2L2 protein [demethoxycurcumin co-treated with bisdemethoxycurcumin] affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA] |
CTD |
PMID:17535857 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
demethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein] |
CTD |
PMID:18449507 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO EXP |
demethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; demethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] |
CTD |
PMID:18449507 PMID:18838107 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression |
ISO |
demethoxycurcumin results in increased expression of NQO1 mRNA; demethoxycurcumin results in increased expression of NQO1 protein |
CTD |
PMID:17535857 PMID:19188863 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Olr1 |
oxidized low density lipoprotein receptor 1 |
multiple interactions |
ISO |
demethoxycurcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of OLR1 mRNA] |
CTD |
PMID:23386263 |
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NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage multiple interactions |
ISO |
demethoxycurcumin results in increased cleavage of PARP1 protein Wortmannin promotes the reaction [demethoxycurcumin results in increased cleavage of PARP1 protein] |
CTD |
PMID:34291863 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pecam1 |
platelet and endothelial cell adhesion molecule 1 |
increases expression |
EXP |
demethoxycurcumin results in increased expression of PECAM1 protein |
CTD |
PMID:17960570 |
|
NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
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G |
Plau |
plasminogen activator, urokinase |
decreases secretion |
ISO |
demethoxycurcumin results in decreased secretion of PLAU protein |
CTD |
PMID:18495463 |
|
NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
affects binding |
ISO |
demethoxycurcumin binds to PPARG protein |
CTD |
PMID:15713005 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Prkcd |
protein kinase C, delta |
multiple interactions |
ISO |
PRKCD protein affects the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA] |
CTD |
PMID:17535857 |
|
NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
demethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; demethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] |
CTD |
PMID:18449507 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Raf1 |
Raf-1 proto-oncogene, serine/threonine kinase |
decreases expression |
ISO |
demethoxycurcumin results in decreased expression of RAF1 protein |
CTD |
PMID:34291863 |
|
NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
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G |
Timp2 |
TIMP metallopeptidase inhibitor 2 |
decreases expression |
ISO |
demethoxycurcumin results in decreased expression of TIMP2 protein |
CTD |
PMID:18495463 |
|
NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
demethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; demethoxycurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] |
CTD |
PMID:18838107 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Vegfa |
vascular endothelial growth factor A |
affects expression multiple interactions |
ISO |
demethoxycurcumin affects the expression of VEGFA mRNA [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of AKT1 protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]; demethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of AKT1 protein]; demethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]; demethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; demethoxycurcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:17960570 PMID:35752269 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Wt1 |
WT1 transcription factor |
decreases expression |
ISO |
demethoxycurcumin results in decreased expression of WT1 mRNA; demethoxycurcumin results in decreased expression of WT1 protein |
CTD |
PMID:18034345 |
|
NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643
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G |
Xiap |
X-linked inhibitor of apoptosis |
decreases expression |
ISO |
demethoxycurcumin results in decreased expression of XIAP protein |
CTD |
PMID:34291863 |
|
NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700
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