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cilostazol - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cilostazol
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Accession:CHEBI:31401 term browser browse the term
Definition:A lactam that is 3,4-dihydroquinolin-2(1H)-one in which the hydrogen at position 6 is substituted by a 4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy group.
Synonyms:exact_synonym: 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydroquinolin-2(1H)-one
 related_synonym: 6-(4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydro-2(1H)-quinolinone;   6-(4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydrocarbostyril;   6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)-butoxy]-3,4-dihydro-1H-quinolin-2-one;   Formula=C20H27N5O2;   InChI=1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26);   InChIKey=RRGUKTPIGVIEKM-UHFFFAOYSA-N;   SMILES=O=C1CCc2cc(OCCCCc3nnnn3C3CCCCC3)ccc2N1;   cilostazolum
 alt_id: CHEBI:150440
 xref: Beilstein:3632017;   CAS:73963-72-1;   DrugBank:DB01166;   Drug_Central:644;   KEGG:D01896;   LINCS:LSM-3491
 xref_mesh: MESH:C045645
 xref: PMID:17500510;   PMID:9873372;   Patent:BE878548;   Patent:US4277479;   VSDB:1939;   Wikipedia:Cilostazol

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cilostazol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO cilostazol increases expression of abca1 protein in liver
cilostazol reverses the reaction [palmitate decreases expression of abca1 protein in hepatoma cells]		 RGD PMID:26362727 PMID:26362727 RGD:21408552, RGD:21408552 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions ISO [Meloxicam co-treated with Cilostazol] results in decreased expression of ABL1 protein CTD PMID:35920412 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases localization ISO cilostazol results in increased localization of AIFM1 protein CTD PMID:20131233 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation		 ISO
EXP		 [Meloxicam co-treated with Cilostazol] results in decreased phosphorylation of AKT1 protein; Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]; iberiotoxin inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]]; paxilline inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]]; PTEN affects the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]]; PTEN affects the reaction [iberiotoxin inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]]]
cilostazol results in increased phosphorylation of AKT1 protein		 CTD PMID:12807996 PMID:15978173 PMID:18556572 PMID:35920412 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Amh anti-Mullerian hormone multiple interactions EXP Cilostazol inhibits the reaction [Cyclophosphamide results in decreased expression of AMH protein] CTD PMID:32456565 NCBI chr 7:8,906,776...8,909,192
Ensembl chr 7:8,906,836...8,909,282 		JBrowse link
G App amyloid beta precursor protein multiple interactions
affects expression		 ISO (E)-3-(2,3,4,5-tetrabromophenyl)acrylic acid inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]]; cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]; KT 5720 inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]]; sirtinol inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]]
cilostazol affects the expression of APP protein		 CTD PMID:24254769 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 affects expression EXP cilostazol affects the expression of ATP2A2 mRNA; cilostazol affects the expression of ATP2A2 protein CTD PMID:18088389 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
affects expression		 ISO
EXP		 Cilostazol results in increased expression of BAX mRNA; Cilostazol results in increased expression of BAX protein
[Cilostazol co-treated with Meloxicam] results in increased expression of BAX mRNA; Cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]
cilostazol affects the expression of BAX protein		 CTD PMID:15978173 PMID:16822680 PMID:20131233 PMID:35920412 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
affects expression		 ISO
EXP		 cilostazol inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]
cilostazol results in decreased expression of BCL2 protein
cilostazol affects the expression of BCL2 protein		 CTD PMID:15978173 PMID:16822680 PMID:20131233 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions EXP cilostazol inhibits the reaction [Nitroprusside results in decreased expression of BID protein modified form]; cilostazol inhibits the reaction [Nitroprusside results in increased cleavage of and results in increased localization of BID protein] CTD PMID:18311796 NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO
EXP		 [Meloxicam co-treated with Cilostazol] results in increased activity of CASP3 protein; KT 5720 inhibits the reaction [Cilostazol results in increased activity of CASP3 protein]
Cilostazol inhibits the reaction [Cyclophosphamide results in increased expression of CASP3 protein]; Cilostazol inhibits the reaction [Nitroprusside results in increased activity of CASP3 protein]		 CTD PMID:18311796 PMID:20131233 PMID:32456565 PMID:35920412 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions EXP cilostazol inhibits the reaction [Nitroprusside results in increased activity of CASP7 protein] CTD PMID:18311796 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 multiple interactions EXP cilostazol inhibits the reaction [Nitroprusside results in increased activity of CASP8 protein] CTD PMID:18311796 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity		 ISO [Meloxicam co-treated with Cilostazol] results in increased activity of CASP9 protein
Cilostazol results in increased activity of CASP9 protein		 CTD PMID:35920412 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO cilostazol inhibits the reaction [TNF protein results in increased expression of CCL2]; cilostazol promotes the reaction [Probucol inhibits the reaction [TNF protein results in increased expression of CCL2]]; Probucol promotes the reaction [cilostazol inhibits the reaction [TNF protein results in increased expression of CCL2]] CTD PMID:19967051 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO cilostazol results in decreased expression of CCNA2 protein CTD PMID:15723965 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO cilostazol results in increased expression of CDKN1A protein CTD PMID:10642304 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
increases activity		 ISO cilostazol promotes the reaction [CFTR protein affects the secretion of Chlorides]
cilostazol results in increased activity of CFTR protein		 CTD PMID:12714375 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases phosphorylation		 ISO
EXP		 Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]; iberiotoxin inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]; paxilline inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]; PTEN affects the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]; PTEN affects the reaction [iberiotoxin inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]]
cilostazol results in increased phosphorylation of CREB1 protein		 CTD PMID:12807996 PMID:15978173 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 increases phosphorylation
multiple interactions		 ISO cilostazol results in increased phosphorylation of CSNK2A1 protein
(E)-3-(2,3,4,5-tetrabromophenyl)acrylic acid inhibits the reaction [cilostazol results in increased phosphorylation of CSNK2A1 protein]; CSNK2A1 protein affects the reaction [cilostazol results in increased phosphorylation of SIRT1 protein]; KT 5720 inhibits the reaction [cilostazol results in increased phosphorylation of CSNK2A1 protein]		 CTD PMID:24254769 NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696 		JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO cilostazol results in decreased expression of E2F1 protein CTD PMID:15723965 NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G E2f2 E2F transcription factor 2 decreases expression ISO cilostazol results in decreased expression of E2F2 protein CTD PMID:15723965 NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217 		JBrowse link
G Ep300 E1A binding protein p300 affects expression
multiple interactions		 ISO cilostazol affects the expression of EP300 protein
(E)-3-(2,3,4,5-tetrabromophenyl)acrylic acid inhibits the reaction [cilostazol affects the expression of EP300 protein]; KT 5720 inhibits the reaction [cilostazol affects the expression of EP300 protein]; SIRT1 protein affects the reaction [cilostazol affects the expression of EP300 protein]; sirtinol inhibits the reaction [cilostazol affects the expression of EP300 protein]		 CTD PMID:24254769 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP Cilostazol inhibits the reaction [Cyclophosphamide results in increased expression of FSHB protein] CTD PMID:32456565 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta affects phosphorylation
multiple interactions		 ISO cilostazol affects the phosphorylation of GSK3B protein
SIRT1 protein affects the reaction [cilostazol affects the phosphorylation of GSK3B protein]		 CTD PMID:24254769 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hmox1 heme oxygenase 1 increases response to substance
multiple interactions
increases expression		 ISO
EXP		 HMOX1 results in increased susceptibility to cilostazol
Cilostazol inhibits the reaction [Cyclophosphamide results in decreased expression of HMOX1 mRNA]; Cilostazol inhibits the reaction [Cyclophosphamide results in decreased expression of HMOX1 protein]; Cilostazol inhibits the reaction [Nitroprusside results in decreased expression of HMOX1 protein]
cilostazol results in increased expression of HMOX1 mRNA; cilostazol results in increased expression of HMOX1 protein
copper protoporphyrin IX inhibits the reaction [cilostazol results in increased expression of HMOX1 protein]; HMOX1 mutant form inhibits the reaction [cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; HMOX1 mutant form inhibits the reaction [cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; HMOX1 mutant form inhibits the reaction [cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; HMOX1 protein promotes the reaction [cilostazol results in increased activity of PPARG protein]; NFE2L2 mutant form inhibits the reaction [cilostazol results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [cilostazol results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [cilostazol results in increased expression of HMOX1 protein]		 CTD PMID:18311796 PMID:20131233 PMID:21256160 PMID:21660147 PMID:32456565 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression		 ISO
EXP		 cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; HMOX1 mutant form inhibits the reaction [cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; zinc protoporphyrin inhibits the reaction [cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]
cilostazol results in decreased expression of IL1B protein
Cilostazol inhibits the reaction [Cyclophosphamide results in increased expression of IL1B mRNA]		 CTD PMID:20131233 PMID:32456565 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO cilostazol inhibits the reaction [4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone results in decreased expression of IL4 protein] CTD PMID:15169552 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 multiple interactions ISO cilostazol inhibits the reaction [4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone results in decreased expression of IL5 protein] CTD PMID:15169552 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression		 ISO
EXP		 cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; HMOX1 mutant form inhibits the reaction [cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; zinc protoporphyrin inhibits the reaction [cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]
cilostazol results in decreased expression of IL6 protein
Cilostazol inhibits the reaction [Cyclophosphamide results in increased expression of IL6 mRNA]		 CTD PMID:20131233 PMID:32456565 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Cilostazol inhibits the reaction [Cyclophosphamide results in increased expression of LHB protein] CTD PMID:32456565 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO cilostazol affects the acetylation of and affects the phosphorylation of MAPT protein; SIRT1 protein affects the reaction [cilostazol affects the acetylation of and affects the phosphorylation of MAPT protein] CTD PMID:24254769 NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [Meloxicam co-treated with Cilostazol] results in decreased expression of MYC protein CTD PMID:35920412 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression
multiple interactions
increases response to substance		 ISO
EXP		 cilostazol results in increased expression of NFE2L2 protein
NFE2L2 mutant form inhibits the reaction [cilostazol results in increased expression of HMOX1 protein]
NFE2L2 results in increased susceptibility to cilostazol
Cilostazol inhibits the reaction [Cyclophosphamide results in decreased expression of NFE2L2 mRNA]; Cilostazol inhibits the reaction [Thioacetamide results in decreased expression of NFE2L2 protein]; Verapamil promotes the reaction [Cilostazol inhibits the reaction [Thioacetamide results in decreased expression of NFE2L2 protein]]		 CTD PMID:20131233 PMID:30295103 PMID:32456565 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression
multiple interactions		 ISO cilostazol results in increased expression of NFKBIA protein
zinc protoporphyrin inhibits the reaction [cilostazol results in increased expression of NFKBIA protein]		 CTD PMID:20131233 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO cilostazol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide] CTD PMID:21256160 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
increases phosphorylation		 ISO cilostazol inhibits the reaction [Everolimus results in decreased expression of NOS3 protein]; cilostazol inhibits the reaction [Paclitaxel results in decreased expression of NOS3 protein]; cilostazol inhibits the reaction [Sirolimus results in decreased expression of NOS3 protein]
cilostazol results in increased phosphorylation of NOS3 protein		 CTD PMID:18556572 PMID:19520256 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP Cilostazol inhibits the reaction [Thioacetamide results in decreased expression of NQO1 protein]; Verapamil promotes the reaction [Cilostazol inhibits the reaction [Thioacetamide results in decreased expression of NQO1 protein]] CTD PMID:30295103 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO cilostazol results in decreased expression of PCNA protein CTD PMID:15723965 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pln phospholamban affects expression EXP cilostazol affects the expression of PLN mRNA; cilostazol affects the expression of PLN protein CTD PMID:18088389 NCBI chr20:32,629,537...32,639,559 JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity
multiple interactions		 ISO cilostazol results in increased activity of PPARG protein
2-chloro-5-nitrobenzanilide inhibits the reaction [cilostazol results in increased activity of PPARG protein]; HMOX1 protein promotes the reaction [cilostazol results in increased activity of PPARG protein]; zinc protoporphyrin inhibits the reaction [cilostazol results in increased activity of PPARG protein]		 CTD PMID:21660147 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions ISO [Meloxicam co-treated with Cilostazol] results in increased expression of and results in increased phosphorylation of PRKAA1 protein CTD PMID:35920412 NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Pten phosphatase and tensin homolog multiple interactions
decreases phosphorylation		 ISO
EXP		 Cilostazol inhibits the reaction [TNF results in increased phosphorylation of PTEN protein]; iberiotoxin inhibits the reaction [Cilostazol inhibits the reaction [TNF results in increased phosphorylation of PTEN protein]]; paxilline inhibits the reaction [Cilostazol inhibits the reaction [TNF results in increased phosphorylation of PTEN protein]]; PTEN affects the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]]; PTEN affects the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]; PTEN affects the reaction [iberiotoxin inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]]]; PTEN affects the reaction [iberiotoxin inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]]
cilostazol results in decreased phosphorylation of PTEN protein		 CTD PMID:12807996 PMID:15978173 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:21256160 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]; zinc protoporphyrin inhibits the reaction [Cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]] CTD PMID:20131233 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions
increases expression
affects expression
increases phosphorylation		 ISO cilostazol inhibits the reaction [Everolimus results in decreased expression of SIRT1 protein]; cilostazol inhibits the reaction [Paclitaxel results in decreased expression of SIRT1 protein]; cilostazol inhibits the reaction [Sirolimus results in decreased expression of SIRT1 protein]
cilostazol results in increased expression of SIRT1 protein
(E)-3-(2,3,4,5-tetrabromophenyl)acrylic acid inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]]; cilostazol affects the expression of and affects the activity of SIRT1 protein; cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]; CSNK2A1 protein affects the reaction [cilostazol results in increased phosphorylation of SIRT1 protein]; KT 5720 inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]]; KT 5720 inhibits the reaction [cilostazol results in increased phosphorylation of SIRT1 protein]; SIRT1 protein affects the reaction [cilostazol affects the acetylation of and affects the phosphorylation of MAPT protein]; SIRT1 protein affects the reaction [cilostazol affects the expression of EP300 protein]; SIRT1 protein affects the reaction [cilostazol affects the phosphorylation of GSK3B protein]; sirtinol inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]]; sirtinol inhibits the reaction [cilostazol results in increased phosphorylation of SIRT1 protein]
cilostazol affects the expression of SIRT1 mRNA		 CTD PMID:18556572 PMID:19520256 PMID:24254769 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO cilostazol inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc29a1 solute carrier family 29 member 1 multiple interactions ISO cilostazol inhibits the reaction [4-nitrobenzylthioinosine binds to SLC29A1 protein]; cilostazol inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine] CTD PMID:28041785 NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP [Verapamil co-treated with Cilostazol] inhibits the reaction [Thioacetamide results in decreased activity of SOD1 protein]; Cilostazol inhibits the reaction [Thioacetamide results in decreased activity of SOD1 protein] CTD PMID:30295103 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
decreases response to substance		 ISO
EXP		 [Cilostazol co-treated with Probucol] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Cilostazol inhibits the reaction [TNF protein results in increased expression of CCL2]; Cilostazol inhibits the reaction [TNF protein results in increased expression of VCAM1]; Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]; Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]; Cilostazol inhibits the reaction [TNF results in increased phosphorylation of PTEN protein]; Cilostazol promotes the reaction [Probucol inhibits the reaction [TNF protein results in increased expression of CCL2]]; Cilostazol promotes the reaction [Probucol inhibits the reaction [TNF protein results in increased expression of VCAM1]]; HMOX1 mutant form inhibits the reaction [Cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; iberiotoxin inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]]; iberiotoxin inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]; iberiotoxin inhibits the reaction [Cilostazol inhibits the reaction [TNF results in increased phosphorylation of PTEN protein]]; paxilline inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]]; paxilline inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]; paxilline inhibits the reaction [Cilostazol inhibits the reaction [TNF results in increased phosphorylation of PTEN protein]]; Probucol promotes the reaction [Cilostazol inhibits the reaction [TNF protein results in increased expression of CCL2]]; Probucol promotes the reaction [Cilostazol inhibits the reaction [TNF protein results in increased expression of VCAM1]]; PTEN affects the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]]; PTEN affects the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]; PTEN affects the reaction [iberiotoxin inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]]]; PTEN affects the reaction [iberiotoxin inhibits the reaction [Cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]]; zinc protoporphyrin inhibits the reaction [Cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; zinc protoporphyrin inhibits the reaction [Cilostazol results in decreased susceptibility to TNF protein]
cilostazol results in decreased expression of TNF protein
cilostazol inhibits the reaction [4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone results in decreased expression of TNF protein]; cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
cilostazol results in decreased susceptibility to TNF protein
Cilostazol inhibits the reaction [Cyclophosphamide results in increased expression of TNF mRNA]		 CTD PMID:12807996 PMID:15169552 PMID:19967051 PMID:20131233 PMID:21256160 More... NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions		 ISO
EXP		 cilostazol results in increased expression of TP53 protein
cilostazol inhibits the reaction [Nitroprusside results in increased phosphorylation of TP53 protein]		 CTD PMID:10642304 PMID:18311796 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO cilostazol inhibits the reaction [TNF protein results in increased expression of VCAM1]; cilostazol promotes the reaction [Probucol inhibits the reaction [TNF protein results in increased expression of VCAM1]]; Probucol promotes the reaction [cilostazol inhibits the reaction [TNF protein results in increased expression of VCAM1]] CTD PMID:19967051 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      application 19697
        pharmaceutical 19534
          drug 19534
            bronchodilator agent 3816
              cilostazol 52
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      carbon group element atom 19763
                        carbon atom 19760
                          organic molecular entity 19760
                            heteroorganic entity 19521
                              organochalcogen compound 19282
                                organooxygen compound 19197
                                  carbon oxoacid 18676
                                    carboxylic acid 18673
                                      carboacyl group 17700
                                        univalent carboacyl group 17700
                                          carbamoyl group 17545
                                            carboxamide 17545
                                              lactam 8392
                                                cilostazol 52
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