Akt1 (AKT serine/threonine kinase 1) - Rat Genome Database

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Gene: Akt1 (AKT serine/threonine kinase 1) Rattus norvegicus
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Symbol: Akt1
Name: AKT serine/threonine kinase 1
RGD ID: 2081
Description: Enables several functions, including ATP binding activity; GTPase activating protein binding activity; and enzyme binding activity. Involved in several processes, including cellular hyperosmotic salinity response; cellular response to epidermal growth factor stimulus; and cellular response to mechanical stimulus. Acts upstream of or within several processes, including negative regulation of cell size; positive regulation of sodium ion transport; and regulation of protein localization. Located in cytosol; dendrite; and nucleus. Used to study artery disease (multiple); autosomal recessive polycystic kidney disease; heroin dependence; impotence; and type 2 diabetes mellitus. Biomarker of several diseases, including brain ischemia; liver disease (multiple); opiate dependence; type 2 diabetes mellitus; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including Cowden syndrome 6; breast cancer (multiple); gastrointestinal system cancer (multiple); pancreatic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human AKT1 (AKT serine/threonine kinase 1); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; adenosine signaling pathway; INTERACTS WITH (+)-catechin; (+)-pilocarpine; (+)-taxifolin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Akt; AKT1 kinase; Murine thymoma viral (v-akt) oncogene homolog 1; PKB; PKB alpha; protein kinase B; protein kinase B alpha; RAC protein kinase alpha RAC-PK alpha; RAC protein kinase alpha, RAC-PK alpha; RAC-alpha serine/threonine-protein kinase; RAC-PK-alpha; thymoma viral proto-oncogene; thymoma viral proto-oncogene 1; v-akt murine thymoma viral oncogene homolog 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Akt1em1Soar
Genetic Models: SD-Akt1em1Soar
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86137,534,810 - 137,555,131 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6137,535,390 - 137,552,610 (-)EnsemblGRCr8
mRatBN7.26131,713,716 - 131,735,319 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6131,713,720 - 131,733,921 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6131,883,770 - 131,900,905 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06132,180,876 - 132,197,963 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06131,543,341 - 131,560,403 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06137,218,398 - 137,239,970 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6137,218,376 - 137,236,258 (-)Ensemblrn6Rnor6.0
Rnor_5.06146,225,955 - 146,247,008 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46137,640,482 - 137,657,552 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6129,262,032 - 129,279,096 (-)NCBICelera
RGSC_v3.16137,646,668 - 137,663,739 (-)NCBI
RH 3.4 Map6782.49RGD
Cytogenetic Map6q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
acute promyelocytic leukemia  (ISO)
adenocarcinoma  (ISO)
alcohol dependence  (IDA)
alcohol-associated liver disease  (ISO)
alcoholic hepatitis  (ISO)
Alzheimer's disease  (ISO)
amphetamine abuse  (ISO)
amyotrophic lateral sclerosis  (ISO)
Animal Disease Models  (ISO)
atherosclerosis  (ISO)
autosomal recessive polycystic kidney disease  (IDA)
bipolar disorder  (ISO)
Brain Injuries  (IEP)
brain ischemia  (IEP)
breast adenocarcinoma  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
Breast Neoplasms  (ISO)
Calcification of Aortic Valve  (ISO)
cannabis abuse  (ISO)
Carcinogenesis  (ISO)
cardiac arrest  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
chronic myeloid leukemia  (ISO)
colon cancer  (IEP,ISO)
colon carcinoma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
coronary artery disease  (ISO)
Cowden syndrome 6  (ISO)
Diabetic Cardiomyopathies  (ISO)
diabetic retinopathy  (IEP)
Endotoxemia  (IEP)
epilepsy  (ISO)
esophageal cancer  (ISO)
esophageal carcinoma  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Arthritis  (IDA)
Experimental Colitis  (IEP)
Experimental Diabetes Mellitus  (IDA,IEP)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
familial adenomatous polyposis  (ISO)
Fibrosis  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatocellular carcinoma  (IEP,ISO)
Hepatomegaly  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
heroin dependence  (IMP)
Hyperplasia  (ISO)
hypertension  (IDA)
Hypertriglyceridemia  (ISO)
idiopathic pulmonary fibrosis  (ISO)
impotence  (IDA)
in situ carcinoma  (ISO)
Inflammation  (ISO)
intermediate coronary syndrome  (ISO)
Intervertebral Disc Displacement  (ISO)
invasive ductal carcinoma  (ISO)
Kidney Neoplasms  (ISO)
left ventricular failure  (ISO)
Lung Injury  (IEP)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
Macrocephaly Mesodermal Hamartoma Spectrum  (ISO)
malignant astrocytoma  (ISO)
Memory Disorders  (ISO)
meningioma  (ISO)
metabolic dysfunction and alcohol associated liver disease  (ISO)
metabolic dysfunction-associated steatohepatitis  (ISO)
metabolic dysfunction-associated steatotic liver disease  (IEP,ISO)
muscular atrophy  (ISO)
myocardial infarction  (IDA,ISO)
Myocardial Reperfusion Injury  (IDA)
Neointima  (ISO)
obesity  (ISO)
opiate dependence  (IEP)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
Pain  (ISO)
pancreatic cancer  (ISO)
pancreatic intraductal papillary-mucinous neoplasm  (ISO)
paraplegia  (IEP)
Parkinson's disease  (ISO)
Postoperative Cognitive Dysfunction  (IEP)
pre-malignant neoplasm  (ISO)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
Proteus syndrome  (ISO,ISS)
pulmonary tuberculosis  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
Right Ventricular Hypertrophy  (IDA)
schizophrenia  (ISO,ISS)
Skin Neoplasms  (ISO)
Spinal Cord Injuries  (IEP)
squamous cell carcinoma  (ISO)
Staphylococcal Pneumonia  (ISO)
steatotic liver disease  (IEP,ISO)
stroke  (ISO)
substance-induced psychosis  (ISO)
T-cell non-Hodgkin lymphoma  (ISO)
type 2 diabetes mellitus  (IDA,IEP,ISO)
ureteral obstruction  (IEP)
urinary bladder cancer  (ISO)
Vascular Remodeling  (IEP)
Ventilator-Induced Lung Injury  (ISO)
Ventricular Remodeling  (IEP,ISO)
vulva cancer  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-beta-thujone  (ISO)
(+)-catechin  (EXP,ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-Eudesmin  (ISO)
(+)-pilocarpine  (EXP)
(+)-taxifolin  (EXP)
(+)-Tetrandrine  (ISO)
(-)-alpha-phellandrene  (ISO)
(-)-Arctigenin  (ISO)
(-)-cotinine  (ISO)
(-)-CP-55940  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-gambogic acid  (ISO)
(-)-selegiline  (EXP)
(-)-trans-epsilon-viniferin  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(20S)-ginsenoside Rh2  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(3,4-dihydroxyphenyl)acetic acid  (EXP)
(R)-adrenaline  (ISO)
(R)-camphor  (ISO)
(R)-carnitine  (EXP)
(R)-linalyl acetate  (ISO)
(R)-lipoic acid  (ISO)
(R)-noradrenaline  (EXP)
(R)-salsolinol  (EXP)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-AMPA  (EXP)
(S)-colchicine  (ISO)
(S)-duloxetine hydrochloride  (EXP)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
(S)-ropivacaine  (ISO)
(Z)-ligustilide  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,3-dichloropropan-2-ol  (ISO)
1,3-Dinitropyrene  (ISO)
1,4-benzoquinone  (ISO)
1,4-dithiothreitol  (ISO)
1,4-naphthoquinone  (ISO)
1,8-cineole  (ISO)
1,8-Dinitropyrene  (ISO)
1-(4-methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-monopalmitoylglycerol  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (EXP,ISO)
10-DEBC hydrochloride  (EXP)
14,15-EET  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
16,16-dimethylprostaglandin E2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 17-glucosiduronic acid  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (EXP)
2,5-hexanedione  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-chloroethanol  (ISO)
2-methoxy-17beta-estradiol  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (ISO)
2-methylcholine  (ISO)
2-tert-butylhydroquinone  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
20-hydroxyecdysone  (EXP)
25-hydroxycholesterol  (ISO)
26-hydroxycholesterol  (ISO)
28-Homobrassinolide  (EXP)
3',5'-cyclic GMP  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-hydroxyisovaleric acid  (EXP)
3-iodobenzyl-5'-N-methylcarboxamidoadenosine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (EXP)
3-methylglutaric acid  (EXP)
3-Nitrobenzanthrone  (ISO)
3-Nitrofluoranthene  (ISO)
3-nitropropanoic acid  (EXP)
3-phenylprop-2-enal  (ISO)
4'-epidoxorubicin  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-\{[4-(dimethylamino)phenyl]diazenyl\}phenyl-beta-lactoside  (ISO)
4-aminophenol  (ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-hydroxy-TEMPO  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitroquinoline N-oxide  (ISO)
4-nonylphenol  (EXP)
4-phenylbutyric acid  (EXP,ISO)
4-vinylcyclohexene dioxide  (ISO)
5'-S-methyl-5'-thioadenosine  (ISO)
5-(2-chloroethyl)-4-methylthiazole  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (EXP,ISO)
5-Hydroxycapric acid  (EXP)
5-methoxypsoralen  (EXP,ISO)
6,7-dimethoxy-2-phenylquinoxaline  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
6-propyl-2-thiouracil  (EXP,ISO)
6alpha-methylprednisolone  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
7-ketocholesterol  (EXP)
8-(4-chlorophenylthio)-cAMP  (EXP)
8-Br-cAMP  (ISO)
9,10-anthraquinone  (ISO)
9-cis-retinoic acid  (EXP,ISO)
[6]-Shogaol  (ISO)
abamectin  (ISO)
Abemaciclib  (ISO)
ABT-100  (ISO)
ABT-737  (ISO)
acadesine  (ISO)
acetic acid  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
adenine  (ISO)
Adiponectin  (EXP)
afatinib  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
agmatine  (ISO)
AH23848  (ISO)
AICA ribonucleotide  (EXP,ISO)
alachlor  (ISO)
albiflorin  (ISO)
alcohol  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
alkaloid  (EXP)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
allethrin  (EXP,ISO)
alloxan  (EXP,ISO)
allyl isothiocyanate  (ISO)
alpha-mangostin  (ISO)
alpha-naphthoflavone  (EXP)
alpha-phellandrene  (ISO)
aluminium hydroxide  (ISO)
alvocidib  (ISO)
AM-251  (ISO)
AM6545  (ISO)
amidotrizoic acid  (ISO)
amiloride  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amosite asbestos  (ISO)
amoxicillin  (EXP,ISO)
amphetamine  (ISO)
ampicillin  (EXP)
anethole  (ISO)
angelicin  (ISO)
aniracetam  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antigen  (ISO)
ANTIMYCIN  (ISO)
antimycin A  (ISO)
Antrocin  (ISO)
apigenin  (ISO)
apocynin  (ISO)
arachidonic acid  (ISO)
arachidonyl-2'-chloroethylamide  (ISO)
arecoline  (EXP,ISO)
arecoline hydrobromide  (ISO)
Arg-Gly-Asp  (EXP)
aristolochic acid A  (EXP,ISO)
aristolochic acids  (ISO)
arotinoid acid  (ISO)
ARS-1620  (ISO)
arsane  (EXP,ISO)
arsenic acid  (ISO)
arsenic atom  (EXP,ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (EXP,ISO)
Arsenobetaine  (ISO)
arsenous acid  (EXP,ISO)
asiatic acid  (EXP,ISO)
aspartame  (ISO)
astaxanthin  (ISO)
astilbin  (ISO)
astragaloside IV  (EXP)
atorvastatin calcium  (EXP,ISO)
ATP  (ISO)
Atpenin A5  (ISO)
atrazine  (ISO)
aucubin  (ISO)
Augmentin  (EXP)
auranofin  (ISO)
aureusidin  (EXP)
Auriculasin  (ISO)
avermectin  (ISO)
azathioprine  (ISO)
AZD4547  (ISO)
AZD8186  (ISO)
Azoxymethane  (EXP)
azoxystrobin  (ISO)
baicalein  (ISO)
baicalin  (ISO)
BAPTA  (EXP)
Bardoxolone methyl  (ISO)
Bavachinin  (ISO)
bazedoxifene  (ISO)
belinostat  (ISO)
bellidifolin  (EXP)
benomyl  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
benzophenanthridine  (ISO)
benzyl isothiocyanate  (ISO)
berberine  (EXP,ISO)
beta-carotene  (ISO)
beta-cyclodextrin  (ISO)
beta-D-glucosamine  (ISO)
beta-lapachone  (ISO)
betalain  (ISO)
Betanin  (ISO)
betulin  (ISO)
betulinic acid  (ISO)
bezafibrate  (EXP,ISO)
bicalutamide  (ISO)
bilirubin IXalpha  (ISO)
biliverdin  (ISO)
biotin  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
BMS-754807  (EXP,ISO)
boric acid  (ISO)
bortezomib  (ISO)
bosutinib  (ISO)
brefeldin A  (EXP)
bufalin  (ISO)
Bufotalin  (ISO)
butan-1-ol  (EXP,ISO)
butein  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
Butylphthalide  (EXP)
butyric acid  (ISO)
C.I. Natural Red 20  (ISO)
Cacalol  (ISO)
cadmium acetate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calcidiol  (ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
calix[6]arene  (ISO)
calyculin A  (ISO)
camphor  (ISO)
camptothecin  (ISO)
canagliflozin  (EXP,ISO)
candesartan  (EXP)
cannabidiol  (ISO)
Cannabidivarin  (ISO)
cannabigerol  (ISO)
cantharidin  (ISO)
capecitabine  (ISO)
capivasertib  (ISO)
capsaicin  (EXP,ISO)
capsazepine  (ISO)
captan  (ISO)
captopril  (ISO)
carbachol  (EXP)
carbamazepine  (ISO)
CARBENOXOLONE  (ISO)
carbon dioxide  (EXP)
carbon monoxide  (EXP,ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carboplatin  (ISO)
carfilzomib  (ISO)
carmustine  (EXP,ISO)
carnosic acid  (ISO)
carnosine  (EXP)
carrageenan  (ISO)
carvedilol  (EXP,ISO)
casticin  (EXP,ISO)
CEDRELONE  (ISO)
cefazolin  (EXP)
cefoperazone  (EXP)
celastrol  (EXP,ISO)
celecoxib  (EXP,ISO)
ceric oxide  (ISO)
ceritinib  (ISO)
ceruletide  (ISO)
chaetoglobosin A  (EXP)
chicoric acid  (EXP)
CHIR 99021  (ISO)
chitosan  (EXP,ISO)
chlordecone  (ISO)
chloroethene  (ISO)
chlorogenic acid  (ISO)
chlorohydrocarbon  (ISO)
chloroquine  (EXP,ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP,ISO)
cholic acid  (ISO)
chromium atom  (EXP,ISO)
chromium(6+)  (EXP,ISO)
chromones  (ISO)
chrysin  (ISO)
chrysophanol  (ISO)
cilostazol  (EXP,ISO)
Cinobufotalin  (ISO)
ciprofloxacin  (ISO)
cisplatin  (EXP,ISO)
citalopram  (ISO)
Citreoviridin  (EXP,ISO)
clozapine  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
coenzyme Q10  (EXP)
colistin  (EXP,ISO)
copanlisib  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(I) chloride  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (EXP,ISO)
coptisine  (ISO)
cordycepin  (EXP,ISO)
corilagin  (EXP,ISO)
corticosterone  (EXP)
cortisol  (EXP)
coumarin  (ISO)
crizotinib  (ISO)
crocidolite asbestos  (EXP,ISO)
Cruentaren A  (ISO)
cucurbitacin E  (ISO)
curcumin  (EXP,ISO)
cyclizine  (ISO)
cycloheximide  (EXP,ISO)
Cyclopamine  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
Cyclosporin H  (ISO)
cyfluthrin  (ISO)
cyhalothrin  (ISO)
cypermethrin  (EXP,ISO)
D-aspartic acid  (EXP,ISO)
D-fructose  (EXP)
D-glucose  (EXP,ISO)
dactolisib  (EXP,ISO)
dapagliflozin  (EXP)
DAPT  (ISO)
daunorubicin  (ISO)
DDE  (ISO)
deferiprone  (EXP)
deguelin  (ISO)
demethoxycurcumin  (ISO)
demethoxyfumitremorgin C  (ISO)
deoxynivalenol  (ISO)
Deoxyschizandrin  (ISO)
desferrioxamine B  (EXP,ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP,ISO)
dextromethorphan  (ISO)
Di-n-octyl phthalate  (EXP,ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP,ISO)
diazoxide  (EXP)
dibenziodolium  (ISO)
dibenzoylmethane  (ISO)
dibutyl phthalate  (EXP,ISO)
dibutylstannane  (ISO)
dichlorine  (EXP)
dichloromethane  (ISO)
diclofenac  (ISO)
Dictamnine  (ISO)
Dicyclohexyl phthalate  (EXP)
dideuterium oxide  (ISO)
Didymin  (ISO)
dieckol  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
dihydro-beta-erythroidine  (ISO)
dihydrolipoamide  (EXP)
dihydrolipoic acid  (EXP,ISO)
Dihydrotanshinone I  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (EXP,ISO)
Dinitramine  (ISO)
dioscin  (ISO)
diosgenin  (ISO)
dioxygen  (EXP,ISO)
dipentyl phthalate  (EXP)
diprotium oxide  (ISO)
diquat  (ISO)
disodium cromoglycate  (EXP)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
dithionite(2-)  (EXP)
divinyl sulfone  (ISO)
dobutamine  (ISO)
dodecanoic acid  (ISO)
Doramectin  (EXP)
dorsomorphin  (ISO)
doxazosin  (EXP)
doxepin  (EXP)
doxorubicin  (EXP,ISO)
echinacoside  (ISO)
eckol  (ISO)
edaravone  (EXP)
elemental selenium  (EXP,ISO)
ellagic acid  (EXP,ISO)
embelin  (ISO)
emodin  (EXP,ISO)
enalapril  (EXP)
endosulfan  (EXP,ISO)
equol  (ISO)
ergothioneine  (EXP)
erlotinib hydrochloride  (ISO)
Erucin  (ISO)
esculetin  (ISO)
estrogen  (EXP)
estrone  (ISO)
ethanol  (EXP,ISO)
ethyl trans-caffeate  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP,ISO)
etoposide  (ISO)
etoxazole  (ISO)
euscaphic acid  (ISO)
everolimus  (EXP,ISO)
Evodiamine  (EXP,ISO)
excitatory amino acid agonist  (EXP)
farnesyl diphosphate  (ISO)
fasudil  (EXP)
fenpyroximate  (ISO)
fenvalerate  (ISO)
ferric ammonium citrate  (ISO)
ferric oxide  (EXP)
ferulic acid  (EXP)
filipin III  (EXP,ISO)
finasteride  (EXP)
fingolimod hydrochloride  (ISO)
fisetin  (EXP,ISO)
flavokawain B  (ISO)
flufenoxuron  (ISO)
fluorometholone  (ISO)
flurbiprofen  (ISO)
flutamide  (EXP,ISO)
fluvastatin  (EXP)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
formononetin  (ISO)
Forsythiaside  (ISO)
FR900359  (ISO)
fraxetin  (ISO)
frenolicin B  (ISO)
fructose  (EXP)
fucoxanthin  (ISO)
fulvestrant  (EXP,ISO)
furazolidone  (ISO)
furosemide  (EXP)
Fusaric acid  (ISO)
gadodiamide hydrate  (ISO)
galangin  (ISO)
gallein  (EXP)
gallic acid  (ISO)
gallocatechin  (ISO)
gamma-aminobutyric acid  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gamma-tocotrienol  (ISO)
Garcinol  (ISO)
gefitinib  (EXP,ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
gemfibrozil  (ISO)
Genipin  (ISO)
Geniposide  (EXP,ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
Geraniin  (ISO)
GGTI-2133  (EXP)
Gingerenone A  (EXP,ISO)
gingerol  (ISO)
Ginkgoic acid  (ISO)
ginkgolide B  (ISO)
ginsenoside Rb1  (ISO)
ginsenoside Rd  (ISO)
ginsenoside Re  (EXP,ISO)
ginsenoside Rg1  (EXP,ISO)
ginsenoside Rg2  (EXP)
Ginsenoside Rg5  (ISO)
Ginsenoside Rh4  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
glutinol  (ISO)
glyburide  (EXP)
glycerol  (ISO)
glycerol 2-phosphate  (ISO)
glycidol  (EXP)
glycyrrhizinic acid  (EXP)
glyphosate  (ISO)
Goe 6976  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GSK690693  (ISO)
gypenoside LXXV  (ISO)
haloperidol  (EXP)
hellebrigenin  (ISO)
hemin  (ISO)
heparin  (EXP)
hesperetin  (EXP)
hesperidin  (EXP)
hexachlorobenzene  (EXP)
hexadecanoic acid  (EXP,ISO)
high-density lipoprotein cholesterol  (ISO)
Hispolon  (ISO)
homocysteine  (ISO)
Honokiol  (ISO)
hyaluronic acid  (EXP)
hydrogen cyanide  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (EXP,ISO)
hydroquinone  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
hydroxyflutamide  (EXP)
hydroxytyrosol  (ISO)
iberiotoxin  (ISO)
IC-87114  (ISO)
icariin  (EXP,ISO)
icariside II  (ISO)
idelalisib  (ISO)
imiquimod  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
insulin  (EXP,ISO)
iodixanol  (ISO)
ionomycin  (ISO)
irbesartan  (ISO)
iron atom  (EXP)
iron dextran  (EXP)
iron(0)  (EXP)
iron(2+) sulfate (anhydrous)  (EXP)
Isobavachin  (ISO)
isoflurane  (EXP,ISO)
Isoliensinine  (ISO)
isoliquiritigenin  (ISO)
isoorientin  (ISO)
isoprenaline  (EXP,ISO)
isorhamnetin  (EXP,ISO)
ivermectin  (ISO)
JTE-013  (EXP)
kaempferol  (EXP,ISO)
kahweol  (ISO)
Kalafungin  (ISO)
ketanserin  (ISO)
Kirenol  (ISO)
KN-93  (EXP,ISO)
kojic acid  (ISO)
KT 5720  (EXP)
Ku-0063794  (ISO)
Kukoamine B  (ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (EXP)
L-ascorbic acid 2-phosphate  (ISO)
L-cysteine  (EXP)
L-gamma-glutamyl-L-cysteine  (EXP)
L-glutamic acid  (ISO)
L-isoprenaline  (EXP)
L-methionine  (EXP,ISO)
L-threonine  (ISO)
lactacystin  (ISO)
lactucin  (ISO)
lapatinib  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
leptomycin B  (ISO)
letrozole  (EXP)
leukotriene B4  (ISO)
leupeptin  (ISO)
leuprolide  (ISO)
Licochalcone A  (ISO)
licoricidin  (ISO)
Liensinine  (ISO)
linagliptin  (EXP)
linalool  (ISO)
linalyl acetate  (ISO)
linderalactone  (ISO)
linsidomine  (EXP,ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (EXP,ISO)
liraglutide  (ISO)
lithium atom  (ISO)
lithium chloride  (EXP,ISO)
lithium hydride  (ISO)
LM-1685  (ISO)
Lobetyolin  (ISO)
loliolide  (ISO)
lonafarnib  (ISO)
lonidamine  (ISO)
lovastatin  (EXP,ISO)
Lupalbigenin  (ISO)
lupeol  (EXP,ISO)
Lupiwighteone  (ISO)
luteolin  (EXP,ISO)
luteolin 7-O-beta-D-glucoside  (ISO)
LY 117018  (ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
lycorine  (ISO)
magnesium atom  (EXP)
Magnolol  (EXP)
malonaldehyde  (ISO)
malvidin  (ISO)
mancozeb  (ISO)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (EXP,ISO)
manumycin A  (EXP)
masoprocol  (ISO)
Mecamylamine  (ISO)
Medermycin  (ISO)
MeIQ  (ISO)
MeIQx  (ISO)
melatonin  (EXP,ISO)
melittin  (ISO)
meloxicam  (ISO)
menaquinone  (EXP)
mercury dichloride  (ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
Methanandamide  (EXP,ISO)
methapyrilene  (ISO)
methimazole  (ISO)
methotrexate  (EXP,ISO)
methoxychlor  (ISO)
methyl caffeate  (ISO)
methyl pyruvate  (ISO)
methylarsonic acid  (ISO)
methylglyoxal  (ISO)
methyllycaconitine  (EXP,ISO)
methylmercury chloride  (EXP,ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
metoprolol  (EXP)
mevalonic acid  (ISO)
mevinphos  (EXP)
miconazole  (ISO)
microcystin-LR  (ISO)
mifepristone  (EXP)
mirabegron  (EXP)
mirtazapine  (EXP)
mitomycin C  (ISO)
Mitoquinone  (EXP)
MK-2206  (EXP,ISO)
ML-7  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
Monobutylphthalate  (EXP,ISO)
monocrotaline  (EXP)
monodansylcadaverine  (ISO)
monosodium L-glutamate  (EXP,ISO)
morin  (EXP,ISO)
morphine  (ISO)
morpholines  (ISO)
Morroniside  (EXP)
morusin  (ISO)
Mumbaistatin  (ISO)
mycophenolic acid  (ISO)
myo-inositol hexakisphosphate  (ISO)
myrtenal  (EXP)
Myrtucommulone A  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-D-aspartic acid  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
N-phosphocreatine  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
N-Vinyl-2-pyrrolidone  (EXP)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
Naftopidil  (ISO)
naloxone  (ISO)
naphthalene  (ISO)
naringin  (EXP,ISO)
Neferine  (EXP,ISO)
neoastilbin  (ISO)
nerolidol  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel subsulfide  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotinamide  (EXP,ISO)
nicotine  (EXP,ISO)
nicotinic acid  (EXP)
nifedipine  (ISO)
nilutamide  (ISO)
nintedanib  (ISO)
Nitidine  (ISO)
nitric oxide  (EXP)
nitroprusside  (EXP,ISO)
nobiletin  (EXP,ISO)
Nonylphenol  (EXP,ISO)
Nookatone  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
nordihydroguaiaretic acid  (EXP)
norlaudanosoline  (EXP)
notoginsenoside R1  (ISO)
novobiocin  (ISO)
NSC 23766  (ISO)
nystatin  (ISO)
o-anisidine  (ISO)
o-cresol  (EXP)
Obacunone  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
Octicizer  (ISO)
okadaic acid  (EXP,ISO)
olanzapine  (ISO)
olaparib  (ISO)
oleanolic acid  (EXP,ISO)
oleic acid  (EXP,ISO)
oleuropein  (ISO)
oligopeptide  (ISO)
olmesartan  (EXP)
Olprinone hydrochloride  (EXP)
omacetaxine mepesuccinate  (ISO)
omipalisib  (ISO)
Ophiopogonin D  (ISO)
organoselenium compound  (EXP,ISO)
orlistat  (ISO)
orotic acid  (ISO)
Ortho-topolin riboside  (ISO)
osimertinib  (ISO)
osthole  (ISO)
OSU-03012  (ISO)
oxaliplatin  (ISO)
oxidopamine  (EXP,ISO)
oxycodone  (EXP,ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paeoniflorin  (EXP)
Paeonol  (EXP,ISO)
palbociclib  (ISO)
palmatine  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
Parthenin  (ISO)
patulin  (ISO)
paxilline  (ISO)
PD 0325901  (ISO)
PD 168393  (EXP)
pentetrazol  (EXP)
pentobarbital  (EXP)
pepstatin A  (ISO)
peptide  (EXP)
perfluorodecanoic acid  (ISO)
perfluoroheptanoic acid  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (EXP)
perifosine  (ISO)
perillyl alcohol  (ISO)
permethrin  (ISO)
peroxynitrous acid  (EXP)
PHA-665752  (ISO)
Phellopterin  (ISO)
phenanthrene  (ISO)
phenethyl caffeate  (ISO)
phenformin  (ISO)
phenobarbital  (EXP)
phenol red  (ISO)
phentermine  (ISO)
phenylarsine oxide  (ISO)
phenylephrine  (EXP,ISO)
PhIP  (ISO)
phloretin  (EXP,ISO)
phloroglucinol  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidic acid  (EXP,ISO)
phosphonoformic acid  (ISO)
phosphoramidon  (ISO)
phylloquinone  (EXP)
phytoestrogen  (EXP)
piclamilast  (EXP)
picoxystrobin  (ISO)
picropodophyllotoxin  (ISO)
pifithrin-alpha hydrobromide  (ISO)
pioglitazone  (EXP)
piperine  (ISO)
pipoxolan  (ISO)
pirfenidone  (ISO)
pirinixic acid  (EXP)
Plantamajoside  (EXP,ISO)
platycodin D  (EXP,ISO)
plerixafor  (EXP,ISO)
plitidepsin  (ISO)
plumbagin  (EXP,ISO)
Polygodial  (EXP)
ponatinib  (ISO)
potassium bromate  (EXP)
potassium cyanide  (ISO)
potassium dichromate  (EXP,ISO)
potassium iodide  (EXP)
pravastatin  (EXP,ISO)
prednisone  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
prilocaine  (ISO)
procaine  (ISO)
procyanidin B1  (ISO)
procyanidin B2  (ISO)
progesterone  (EXP,ISO)
promegestone  (EXP)
propazine  (ISO)
propiconazole  (EXP)
propofol  (EXP,ISO)
propranolol  (ISO)
propylparaben  (ISO)
prostaglandin E2  (EXP,ISO)
protosappanin A  (ISO)
pterostilbene  (ISO)
puerarin  (ISO)
PX-866  (ISO)
pyocyanine  (ISO)
pyrethrins  (ISO)
pyrithione  (EXP)
pyrrolidine dithiocarbamate  (ISO)
pyrvinium  (ISO)
quartz  (ISO)
quercetagetin  (EXP)
quercetin  (EXP,ISO)
quercetin 4'-O-beta-D-glucopyranoside  (ISO)
quizartinib  (ISO)
rac-1-monopalmitoylglycerol  (ISO)
raffinose  (EXP,ISO)
raloxifene  (EXP,ISO)
razoxane  (EXP)
regorafenib  (EXP,ISO)
reparixin  (ISO)
reserpine  (ISO)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
ribavirin  (ISO)
riboflavin  (ISO)
rimonabant  (EXP,ISO)
ritonavir  (ISO)
rivastigmine  (EXP)
roflumilast  (EXP)
rolipram  (EXP)
romidepsin  (ISO)
rosuvastatin calcium  (EXP)
rotenone  (EXP,ISO)
rottlerin  (ISO)
rubimaillin  (ISO)
Ruscogenin  (ISO)
Rutamarin  (ISO)
ruthenium atom  (ISO)
ruthenium red  (ISO)
rutin  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
sabinene  (ISO)
Salidroside  (EXP)
salubrinal  (EXP)
salvianolic acid B  (EXP)
sapanisertib  (ISO)
sarpogrelate  (ISO)
SB 203580  (ISO)
SB 431542  (EXP,ISO)
sclareol  (ISO)
scopolamine  (EXP)
selenium atom  (EXP,ISO)
semilicoisoflavone B  (ISO)
serotonin  (ISO)
serpentine asbestos  (ISO)
sertraline  (EXP)
sevoflurane  (EXP)
Shikonin  (ISO)
sildenafil citrate  (EXP)
silibinin  (ISO)
silicon atom  (ISO)
silicon dioxide  (EXP,ISO)
silmitasertib  (ISO)
simazine  (ISO)
simvastatin  (EXP,ISO)
sinensetin  (ISO)
Sinomenine  (ISO)
sirolimus  (EXP,ISO)
sirtinol  (ISO)
SNX-2112  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (EXP)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP,ISO)
sodium nitrite  (EXP)
solasodine  (ISO)
sorafenib  (EXP,ISO)
spathulenol  (ISO)
sphingosine 1-phosphate  (ISO)
squalene  (EXP)
SR 144528  (ISO)
stattic  (ISO)
staurosporine  (EXP,ISO)
stilbenoid  (ISO)
streptozocin  (EXP,ISO)
succimer  (EXP)
sulfadimethoxine  (EXP)
sulfasalazine  (EXP)
sulforaphane  (EXP,ISO)
sulfur dioxide  (EXP)
sulindac  (EXP,ISO)
sulindac sulfone  (EXP,ISO)
sunitinib  (ISO)
swainsonine  (ISO)
syringic acid  (ISO)
T-2 toxin  (EXP,ISO)
tadalafil  (EXP)
taiwanin C  (ISO)
tamarixetin  (ISO)
tamoxifen  (ISO)
tanespimycin  (EXP,ISO)
Tanshinone I  (EXP,ISO)
taraxasterol  (ISO)
taurine  (EXP,ISO)
taurocholic acid  (EXP)
taurolithocholic acid  (EXP)
tauroursodeoxycholic acid  (EXP)
tebufenpyrad  (ISO)
temozolomide  (ISO)
Temsirolimus  (ISO)
tephrosin  (ISO)
terbutylazine  (ISO)
Terfenadine  (ISO)
teriflunomide  (ISO)
terpinolene  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP,ISO)
Tetrachlorobisphenol A  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (ISO)
tetrathiomolybdate(2-)  (ISO)
thalidomide  (ISO)
thapsigargin  (EXP,ISO)
Theaflavin 3,3'-digallate  (EXP,ISO)
theobromine  (EXP)
thiamine(1+) chloride  (EXP,ISO)
thifluzamide  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
Thiorphan  (ISO)
thiram  (ISO)
thymoquinone  (ISO)
thyroxine  (EXP)
tipifarnib  (ISO)
titanium dioxide  (ISO)
tofacitinib  (ISO)
toluene 2,4-diisocyanate  (ISO)
toosendanin  (ISO)
topiramate  (EXP)
Tormentic acid  (ISO)
trametinib  (ISO)
trans-anethole  (ISO)
triadimefon  (EXP)
triamcinolone  (EXP)
tributylstannane  (EXP,ISO)
Tributyltin oxide  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triciribine  (ISO)
triclosan  (EXP,ISO)
trifluoperazine  (EXP,ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (EXP,ISO)
Triptolide  (EXP,ISO)
triptonide  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (ISO)
tropisetron  (EXP)
trovafloxacin  (ISO)
Tryptanthrine  (ISO)
tunicamycin  (EXP,ISO)
Tylophorine  (ISO)
tyrphostin AG 1478  (EXP,ISO)
U-73122  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
ursolic acid  (ISO)
Ursonic acid  (ISO)
usnic acid  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vandetanib  (ISO)
vanillic acid  (ISO)
veliparib  (ISO)
vemurafenib  (ISO)
venlafaxine hydrochloride  (EXP)
verapamil  (EXP)
Vernodalol  (ISO)
vildagliptin  (EXP)
vinclozolin  (ISO)
vincristine  (EXP,ISO)
vitamin E  (EXP,ISO)
vorinostat  (ISO)
VX nerve agent  (EXP)
warfarin  (EXP)
water  (ISO)
WIN 55212-2  (EXP,ISO)
withaferin A  (EXP)
wogonin  (ISO)
wortmannin  (EXP,ISO)
WP1066  (ISO)
xanthohumol  (ISO)
xanthosine  (EXP)
Y-27632  (ISO)
zalcitabine  (EXP)
zearalenone  (EXP,ISO)
zerumbone  (ISO)
zidovudine  (EXP)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (EXP)
zinc sulfate  (EXP,ISO)
zinc(0)  (EXP,ISO)
zingerone  (ISO)
zingiberene  (EXP)
ziram  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation-induced cell death of T cells  (ISO)
apoptotic mitochondrial changes  (ISO)
apoptotic process  (IEA)
behavioral response to pain  (IEA,ISO)
cell migration involved in sprouting angiogenesis  (IEA,ISO)
cell projection organization  (IDA)
cellular hyperosmotic salinity response  (IDA)
cellular response to decreased oxygen levels  (ISO)
cellular response to epidermal growth factor stimulus  (IDA,IEA,ISO,ISS)
cellular response to granulocyte macrophage colony-stimulating factor stimulus  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to heat  (IDA)
cellular response to hypoxia  (IDA)
cellular response to insulin stimulus  (IDA,IEA,IMP,ISO,ISS)
cellular response to mechanical stimulus  (IDA)
cellular response to nerve growth factor stimulus  (IDA,IEA,IEP,ISO)
cellular response to oxidised low-density lipoprotein particle stimulus  (IEA,ISO)
cellular response to peptide  (IEP,ISO)
cellular response to platelet-derived growth factor stimulus  (IDA)
cellular response to prostaglandin E stimulus  (ISO)
cellular response to sorbitol  (IDA)
cellular response to tumor necrosis factor  (ISO)
cellular response to vascular endothelial growth factor stimulus  (ISO)
complement receptor mediated signaling pathway  (IEA,ISO)
DNA damage response  (IDA)
epidermal growth factor receptor signaling pathway  (IEA,ISO)
establishment of protein localization to mitochondrion  (IEA,ISO)
execution phase of apoptosis  (ISO)
gene expression  (ISO)
germ cell development  (ISO)
glucose homeostasis  (ISO)
glucose metabolic process  (IEA,ISO)
glycogen biosynthetic process  (IEA,IMP)
glycogen cell differentiation involved in embryonic placenta development  (ISO)
glycogen metabolic process  (IEA,ISO)
inflammatory response  (ISO)
insulin receptor signaling pathway  (IBA,IDA,IEA,IMP,ISO,ISS)
insulin-like growth factor receptor signaling pathway  (IEA,ISO,ISS)
interleukin-18-mediated signaling pathway  (IEA,ISO)
intracellular signal transduction  (IBA,ISO)
labyrinthine layer blood vessel development  (ISO)
lateral motor column neuron differentiation  (ISO)
lipopolysaccharide-mediated signaling pathway  (ISO)
maintenance of protein location in mitochondrion  (IEA,ISO)
mammalian oogenesis stage  (ISO)
maternal placenta development  (ISO)
negative regulation of apoptotic process  (IBA,IEA,ISO,TAS)
negative regulation of autophagy  (IEA,ISO)
negative regulation of calcium import into the mitochondrion  (IMP)
negative regulation of cell size  (IDA)
negative regulation of cGAS/STING signaling pathway  (IEA,ISO)
negative regulation of cilium assembly  (IEA,ISO,ISS)
negative regulation of fatty acid beta-oxidation  (IEA,ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway  (IEA,ISO)
negative regulation of intrinsic apoptotic signaling pathway  (IEA,ISO)
negative regulation of JNK cascade  (IDA)
negative regulation of leukocyte cell-cell adhesion  (IEA,ISO)
negative regulation of long-chain fatty acid import across plasma membrane  (IEA,ISO)
negative regulation of lymphocyte migration  (IEA,ISO)
negative regulation of PERK-mediated unfolded protein response  (IEA,ISO)
negative regulation of protein localization to lysosome  (IEA,ISO,ISS)
negative regulation of protein ubiquitination  (IEA,ISO)
negative regulation of proteolysis  (IEA,ISO)
negative regulation of release of cytochrome c from mitochondria  (IEA,ISO,ISS)
negative regulation of superoxide anion generation  (IMP)
nervous system development  (IEA)
osteoblast differentiation  (IEA,ISO)
peptidyl-serine phosphorylation  (ISO)
peptidyl-threonine phosphorylation  (ISO)
peripheral nervous system myelin maintenance  (ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IDA,IEA,ISO)
positive regulation of anaphase-promoting complex-dependent catabolic process  (IEA,ISO)
positive regulation of apoptotic process  (IMP)
positive regulation of blood vessel endothelial cell migration  (IBA,IEA,ISO)
positive regulation of cell growth  (IDA,IEA,ISO)
positive regulation of cell migration  (IEA,ISO)
positive regulation of D-glucose import across plasma membrane  (IEA,ISO)
positive regulation of endodeoxyribonuclease activity  (ISO)
positive regulation of endothelial cell migration  (IEA,ISO)
positive regulation of endothelial cell proliferation  (IEA,ISO,ISS)
positive regulation of fat cell differentiation  (IEA,ISO)
positive regulation of fibroblast migration  (ISO)
positive regulation of G1/S transition of mitotic cell cycle  (ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of glucose metabolic process  (IEA,ISO)
positive regulation of glycogen biosynthetic process  (IEA,ISO)
positive regulation of lipid biosynthetic process  (IEA,ISO,ISS)
positive regulation of mitochondrial membrane potential  (IMP)
positive regulation of nitric oxide biosynthetic process  (IEA,ISO)
positive regulation of organ growth  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IEA,ISO)
positive regulation of protein localization to cell surface  (IEA,ISO)
positive regulation of protein localization to endoplasmic reticulum  (IEA,ISO)
positive regulation of protein localization to nucleus  (IEA,ISO)
positive regulation of protein localization to plasma membrane  (IEA,ISO)
positive regulation of protein metabolic process  (IMP)
positive regulation of smooth muscle cell proliferation  (IEA,ISO)
positive regulation of sodium ion transport  (IEA,IMP,ISO)
positive regulation of TORC1 signaling  (IEA,ISO,ISS)
positive regulation of TORC2 signaling  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of vasoconstriction  (IMP)
protein autophosphorylation  (IDA)
protein catabolic process  (ISO)
protein import into nucleus  (IEA,ISO)
protein modification process  (IDA)
protein phosphorylation  (IDA,ISO,ISS)
protein stabilization  (ISO)
protein ubiquitination  (ISO)
regulation of aerobic respiration  (IMP)
regulation of apoptotic process  (IEA,ISO,ISS)
regulation of cell migration  (IEA,IMP,ISO)
regulation of glycogen biosynthetic process  (IEA,ISO)
regulation of myelination  (ISO)
regulation of neuron projection development  (IEA,ISO,ISS)
regulation of postsynapse organization  (IEA,ISO)
regulation of protein localization  (IMP,ISO)
regulation of translation  (IEA)
regulation of tRNA methylation  (IEA,ISO)
response to fluid shear stress  (IEA,ISO)
response to food  (ISO)
response to growth factor  (IEA,ISO)
response to growth hormone  (ISS)
response to heat  (IEA,ISO)
response to hormone  (IEA,ISO)
response to insulin-like growth factor stimulus  (ISS)
response to ischemia  (IEP)
response to muscle activity  (IDA)
response to nutrient levels  (IDA)
response to oxidative stress  (ISS)
response to UV-A  (IEA,ISO)
smoothened signaling pathway  (ISO)
sphingosine-1-phosphate receptor signaling pathway  (IEA,ISO)
spinal cord development  (IDA)
striated muscle cell differentiation  (ISO)
translation  (IMP)

Cellular Component
cell-cell junction  (IEA,ISO)
ciliary basal body  (IEA,ISO)
cytoplasm  (IEA,ISO)
cytosol  (IDA,IEA,ISO,TAS)
dendrite  (IDA)
glutamatergic synapse  (IEA,ISO)
membrane  (IEA,ISO)
mitochondrial intermembrane space  (IEA,ISO,ISS)
mitochondrion  (IEA,ISO)
nucleoplasm  (IEA,TAS)
nucleus  (IDA,IEA,ISO,ISS)
plasma membrane  (IEA,ISO,ISS)
protein-containing complex  (IEA,ISO)
spindle  (IEA,ISO)
vesicle  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
acute myeloid leukemia pathway  (IEA)
adenosine signaling pathway  (ISO)
altered phosphatidylinositol 3-kinase-Akt signaling pathway  (ISO)
apoptotic cell death pathway  (IEA)
B cell receptor signaling pathway  (IEA)
ceramide signaling pathway  (IEA,ISO)
Chagas disease pathway  (IEA)
chemokine mediated signaling pathway  (IEA)
chronic myeloid leukemia pathway   (IEA)
colorectal cancer pathway  (IEA)
E-cadherin signaling pathway  (ISO)
eicosanoid signaling pathway   (ISO)
endometrial cancer pathway  (IEA)
endothelin signaling pathway   (ISO)
epidermal growth factor/neuregulin signaling pathway   (IEA)
FasL mediated signaling pathway  (ISO)
Fc epsilon receptor mediated signaling pathway  (IEA,ISO)
Fc gamma receptor mediated signaling pathway  (IEA)
fibroblast growth factor signaling pathway  (ISO)
forkhead class A signaling pathway  (ISO)
glioma pathway   (IEA)
Hedgehog signaling pathway  (ISO)
hepatitis C pathway   (IEA)
hypoxia inducible factor pathway  (ISO)
influenza A pathway   (IEA)
insulin responsive facilitative sugar transporter mediated glucose transport pathway   (IMP,ISO)
insulin signaling pathway  (IEA,ISO)
insulin-like growth factor signaling pathway  (ISO)
interleukin-4 signaling pathway   (ISO)
interleukin-6 signaling pathway   (ISO)
Jak-Stat signaling pathway  (IEA)
measles pathway  (IEA)
melanoma pathway   (IEA)
mitogen activated protein kinase signaling pathway   (IEA)
mTOR signaling pathway  (IEA,ISO)
neurotrophic factor signaling pathway   (IEA)
non-small cell lung carcinoma pathway   (IEA,ISO)
p53 signaling pathway   (ISO)
pancreatic cancer pathway   (IEA)
phosphatidylinositol 3-kinase-Akt signaling pathway   (IDA,IMP,ISO)
prostate cancer pathway   (IEA)
Reelin signaling pathway   (ISO)
renal cell carcinoma pathway  (IEA)
small cell lung carcinoma pathway  (IEA)
sphingosine 1-phosphate signaling pathway  (ISO)
T cell receptor signaling pathway   (IEA)
Toll-like receptor signaling pathway  (IEA)
toxoplasmosis pathway  (IEA)
tuberculosis pathway  (IEA)
type II interferon signaling pathway   (ISO)
vascular endothelial growth factor signaling pathway  (IEA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
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3. Nuclear Akt associates with PKC-phosphorylated Ebp1, preventing DNA fragmentation by inhibition of caspase-activated DNase. Ahn JY, etal., EMBO J. 2006 May 17;25(10):2083-95. Epub 2006 Apr 27.
4. Effects of MS-153 on chronic ethanol consumption and GLT1 modulation of glutamate levels in male alcohol-preferring rats. Alhaddad H, etal., Front Behav Neurosci. 2014 Oct 30;8:366. doi: 10.3389/fnbeh.2014.00366. eCollection 2014.
5. Nerve growth factor promotes activation of the alpha, beta and gamma isoforms of protein kinase B in PC12 pheochromocytoma cells. Andjelković M, etal., Eur J Biochem. 1998 Jan 15;251(1-2):195-200. doi: 10.1046/j.1432-1327.1998.2510195.x.
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7. Phosphorylated AKT expression is associated with PIK3CA mutation, low stage, and favorable outcome in 717 colorectal cancers. Baba Y, etal., Cancer. 2011 Apr 1;117(7):1399-408. doi: 10.1002/cncr.25630. Epub 2010 Nov 8.
8. Akt1 deficiency in schizophrenia and impairment of hippocampal plasticity and function. Balu DT, etal., Hippocampus. 2010 Nov 3.
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10. Akt1 genetic deficiency limits hypothermia cardioprotection following murine cardiac arrest. Beiser DG, etal., Am J Physiol Heart Circ Physiol. 2010 Jun;298(6):H1761-8. Epub 2010 Apr 2.
11. Altered nitric oxide/cGMP platelet signaling pathway in platelets from patients with acute coronary syndromes. Bergandi L, etal., Clin Res Cardiol. 2010 Sep;99(9):557-64. Epub 2010 May 14.
12. The Akt pathway in human breast cancer: a tissue-array-based analysis. Bose S, etal., Mod Pathol. 2006 Feb;19(2):238-45.
13. Insulin increases the association of Akt-2 with Glut4-containing vesicles. Calera MR, etal., J Biol Chem. 1998 Mar 27;273(13):7201-4.
14. A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Carpten JD, etal., Nature. 2007 Jul 26;448(7152):439-44. Epub 2007 Jul 4.
15. Differential Effects of PI3K and Dual PI3K/mTOR Inhibition in Rat Prolactin-Secreting Pituitary Tumors. Chanal M, etal., Mol Cancer Ther. 2016 Jun;15(6):1261-70. doi: 10.1158/1535-7163.MCT-15-0891. Epub 2016 Mar 16.
16. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Chen WS, etal., Genes Dev 2001 Sep 1;15(17):2203-8.
17. Leptin deficiency and beta-cell dysfunction underlie type 2 diabetes in compound Akt knockout mice. Chen WS, etal., Mol Cell Biol. 2009 Jun;29(11):3151-62. Epub 2009 Mar 16.
18. Caffeic acid phenethyl ester suppresses the proliferation of human prostate cancer cells through inhibition of p70S6K and Akt signaling networks. Chuu CP, etal., Cancer Prev Res (Phila). 2012 May;5(5):788-97. doi: 10.1158/1940-6207.CAPR-12-0004-T.
19. Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice. Condorelli G, etal., Proc Natl Acad Sci U S A 2002 Sep 17;99(19):12333-8.
20. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Cross DA, etal., Nature. 1995 Dec 21-28;378(6559):785-9.
21. Dissociation of Akt/PKB and ribosomal S6 kinase signaling markers in a transgenic mouse model of Alzheimer's disease. Damjanac M, etal., Neurobiol Dis. 2008 Feb;29(2):354-67. Epub 2007 Oct 11.
22. Chronic gestational exposure to ethanol impairs insulin-stimulated survival and mitochondrial function in cerebellar neurons. de la Monte SM and Wands JR
23. Protein kinase B (PKB/AKT1) formed signaling complexes with mitochondrial proteins and prevented glycolytic energy dysfunction in cultured cardiomyocytes during ischemia-reperfusion injury. Deng W, etal., Endocrinology. 2014 May;155(5):1618-28. doi: 10.1210/en.2013-1817. Epub 2014 Mar 6.
24. Akt1 is critical for acute inflammation and histamine-mediated vascular leakage. Di Lorenzo A, etal., Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14552-7. Epub 2009 Jul 21.
25. Genetic Variations of AKT1 are Associated with Risk Screening for Non-Alcoholic Fatty Liver Disease. Ding Y, etal., Risk Manag Healthc Policy. 2023 Jul 26;16:1365-1376. doi: 10.2147/RMHP.S416592. eCollection 2023.
26. Gene and protein expression associated with protein synthesis and breakdown in paraplegic skeletal muscle. Drummond MJ, etal., Muscle Nerve. 2008 Apr;37(4):505-13.
27. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Dudek H, etal., Science. 1997 Jan 31;275(5300):661-5. doi: 10.1126/science.275.5300.661.
28. Bioactivity of Samsum ant (Pachycondyla sennaarensis) venom against lipopolysaccharides through antioxidant and upregulation of Akt1 signaling in rats. Ebaid H, etal., Lipids Health Dis. 2012 Jul 23;11:93. doi: 10.1186/1476-511X-11-93.
29. AKT1 loss correlates with episomal HPV16 in vulval intraepithelial neoplasia. Ekeowa-Anderson AL, etal., PLoS One. 2012;7(6):e38608. doi: 10.1371/journal.pone.0038608. Epub 2012 Jun 7.
30. Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia. Emamian ES, etal., Nat Genet 2004 Feb;36(2):131-7. Epub 2004 Jan 25.
31. Attenuation of ischemia-reperfusion injury by sevoflurane postconditioning involves protein kinase B and glycogen synthase kinase 3 beta activation in isolated rat hearts. Fang NX, etal., Mol Biol Rep. 2010 Dec;37(8):3763-9. Epub 2010 Mar 10.
32. Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease. Fernandez-Hernando C, etal., Cell Metab. 2007 Dec;6(6):446-57.
33. PI3K/Akt: getting it right matters. Franke TF Oncogene. 2008 Oct 27;27(50):6473-88.
34. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Franke TF, etal., Cell. 1995 Jun 2;81(5):727-36. doi: 10.1016/0092-8674(95)90534-0.
35. Loss of PTEN expression is associated with poor prognosis in patients with intraductal papillary mucinous neoplasms of the pancreas. Garcia-Carracedo D, etal., Clin Cancer Res. 2013 Dec 15;19(24):6830-41. doi: 10.1158/1078-0432.CCR-13-0624. Epub 2013 Oct 16.
36. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
37. Acute modulation of vasoconstrictor responses by pravastatin in small vessels. Ghaffari N, etal., Circ J. 2011 May 25;75(6):1506-14. Epub 2011 Apr 29.
38. No Association Between AKT1 Polymorphisms and Methamphetamine Addiction in Iranian Population. Ghafouri-Fard S, etal., J Mol Neurosci. 2020 Mar;70(3):303-307. doi: 10.1007/s12031-019-01413-w. Epub 2019 Oct 25.
39. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
40. Amoxicillin and amoxicillin/clavulanate reduce ethanol intake and increase GLT-1 expression as well as AKT phosphorylation in mesocorticolimbic regions. Goodwani S, etal., Brain Res. 2015 Oct 5;1622:397-408. doi: 10.1016/j.brainres.2015.07.008. Epub 2015 Jul 10.
41. IKK beta and phosphatidylinositol 3-kinase/Akt participate in non-pathogenic Gram-negative enteric bacteria-induced RelA phosphorylation and NF-kappa B activation in both primary and intestinal epithelial cell lines. Haller D, etal., J Biol Chem 2002 Oct 11;277(41):38168-78.
42. Rapamycin treatment augments both protein ubiquitination and Akt activation in pressure-overloaded rat myocardium. Harston RK, etal., Am J Physiol Heart Circ Physiol. 2011 May;300(5):H1696-706. doi: 10.1152/ajpheart.00545.2010. Epub 2011 Feb 25.
43. Co-existence of high levels of the PTEN protein with enhanced Akt activation in renal cell carcinoma. He L, etal., Biochim Biophys Acta. 2007 Oct;1772(10):1134-42. Epub 2007 Jul 12.
44. Akt mediates insulin induction of glucose uptake and up-regulation of GLUT4 gene expression in brown adipocytes. Hernandez R, etal., FEBS Lett. 2001 Apr 13;494(3):225-31.
45. Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradiotherapy. Hildebrandt MA, etal., J Clin Oncol. 2009 Feb 20;27(6):857-71. doi: 10.1200/JCO.2008.17.6297. Epub 2009 Jan 21.
46. Potential role of Akt in the regulation of fibroblast growth factor 21 by berberine. Hirai T, etal., J Nat Med. 2024 Jan;78(1):169-179. doi: 10.1007/s11418-023-01755-1. Epub 2023 Nov 11.
47. Phosphoinositide 3-kinases as a common platform for multi-hormone signaling. Hirsch E, etal., J Endocrinol. 2007 Aug;194(2):243-56.
48. Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice. Holland EC, etal., Nat Genet 2000 May;25(1):55-7.
49. Akt-mediated cardiomyocyte survival pathways are compromised by G alpha q-induced phosphoinositide 4,5-bisphosphate depletion. Howes AL, etal., J Biol Chem 2003 Oct 10;278(41):40343-51. Epub 2003 Aug 4.
50. ATP-mediated protein kinase B Akt/mammalian target of rapamycin mTOR/p70 ribosomal S6 protein p70S6 kinase signaling pathway activation promotes improvement of locomotor function after spinal cord injury in rats. Hu LY, etal., Neuroscience. 2010 Sep 1;169(3):1046-62. doi: 10.1016/j.neuroscience.2010.05.046. Epub 2010 Jun 1.
51. Co-administration of finasteride and the pure anti-oestrogen ICI 182,780 act synergistically in modulating the IGF system in rat prostate. Huynh H, etal., J Endocrinol 2001 Oct;171(1):109-18.
52. Positive association of AKT1 haplotype to Japanese methamphetamine use disorder. Ikeda M, etal., Int J Neuropsychopharmacol. 2006 Feb;9(1):77-81. doi: 10.1017/S1461145705005481. Epub 2005 Jun 28.
53. Integrated strategy of network pharmacology, molecular docking, HPLC-DAD and mice model for exploring active ingredients and pharmacological mechanisms of Penthorum chinense Pursh against alcoholic liver injury. Jiang Y, etal., J Ethnopharmacol. 2022 Nov 15;298:115589. doi: 10.1016/j.jep.2022.115589. Epub 2022 Aug 2.
54. Phosphorylation levels of BCR-ABL, CrkL, AKT and STAT5 in imatinib-resistant chronic myeloid leukemia cells implicate alternative pathway usage as a survival strategy. Jilani I, etal., Leuk Res. 2008 Apr;32(4):643-9. doi: 10.1016/j.leukres.2007.08.009. Epub 2007 Sep 27.
55. The phosphatidylinositol 3-kinase/Akt signaling pathway modulates the endocrine differentiation of trophoblast cells. Kamei T, etal., Mol Endocrinol 2002 Jul;16(7):1469-81.
56. Association of AKT1 gene variants and protein expression in both schizophrenia and bipolar disorder. Karege F, etal., Genes Brain Behav. 2010 Jul;9(5):503-11. Epub 2010 Feb 27.
57. Estrogen-induced activation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor expression, and edema in the uterus are mediated by the phosphatidylinositol 3-kinase/Akt pathway. Kazi AA and Koos RD, Endocrinology. 2007 May;148(5):2363-74. doi: 10.1210/en.2006-1394. Epub 2007 Feb 1.
58. Akt1 regulates a JNK scaffold during excitotoxic apoptosis. Kim AH, etal., Neuron 2002 Aug 15;35(4):697-709.
59. Mutational analysis of oncogenic AKT E17K mutation in common solid cancers and acute leukaemias. Kim MS, etal., Br J Cancer. 2008 May 6;98(9):1533-5. doi: 10.1038/sj.bjc.6604212. Epub 2008 Apr 8.
60. Mitochondrial E3 Ubiquitin Protein Ligase 1 Mediates Cigarette Smoke-Induced Endothelial Cell Death and Dysfunction. Kim SY, etal., Am J Respir Cell Mol Biol. 2016 Feb;54(2):284-96. doi: 10.1165/rcmb.2014-0377OC.
61. The role of autophagy in unilateral ureteral obstruction rat model. Kim WY, etal., Nephrology (Carlton). 2012 Feb;17(2):148-59. doi: 10.1111/j.1440-1797.2011.01541.x.
62. Fatty acid infusion selectively impairs insulin action on Akt1 and protein kinase C lambda /zeta but not on glycogen synthase kinase-3. Kim YB, etal., J Biol Chem 2002 Sep 6;277(36):32915-22.
63. Requirement for activation of the serine-threonine kinase Akt (protein kinase B) in insulin stimulation of protein synthesis but not of glucose transport. Kitamura T, etal., Mol Cell Biol. 1998 Jul;18(7):3708-17.
64. Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt. Kitamura T, etal., Mol Cell Biol. 1999 Sep;19(9):6286-96.
65. Nicotinamide attenuates the ischemic brain injury-induced decrease of Akt activation and Bad phosphorylation. Koh PO Neurosci Lett. 2011 Jul 8;498(2):105-9. Epub 2011 May 8.
66. Molecular cloning of rat RAC protein kinase alpha and beta and their association with protein kinase C zeta. Konishi H, etal., Biochem Biophys Res Commun 1994 Nov 30;205(1):817-25.
67. Molecular cloning and characterization of a new member of the RAC protein kinase family: association of the pleckstrin homology domain of three types of RAC protein kinase with protein kinase C subspecies and beta gamma subunits of G proteins. Konishi H, etal., Biochem Biophys Res Commun 1995 Nov 13;216(2):526-34.
68. Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of phosphatidylinositol 3-kinase. Konishi H, etal., Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7639-43. doi: 10.1073/pnas.93.15.7639.
69. PKB/Akt partners with Dab2 in albumin endocytosis. Koral K and Erkan E, Am J Physiol Renal Physiol. 2012 Apr 15;302(8):F1013-24. doi: 10.1152/ajprenal.00289.2011. Epub 2012 Jan 4.
70. The AKT1-FOXO4 axis reciprocally regulates hemochorial placentation. Kozai K, etal., Development. 2023 Jan 15;150(2):dev201095. doi: 10.1242/dev.201095. Epub 2023 Jan 17.
71. Caffeic acid phenethyl ester suppresses proliferation and survival of TW2.6 human oral cancer cells via inhibition of Akt signaling. Kuo YY, etal., Int J Mol Sci. 2013 Apr 24;14(5):8801-17. doi: 10.3390/ijms14058801.
72. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
73. Genetic polymorphisms in inflammation pathway genes and prostate cancer risk. Kwon EM, etal., Cancer Epidemiol Biomarkers Prev. 2011 May;20(5):923-33. Epub 2011 Mar 23.
74. Ontology searching and browsing at the Rat Genome Database. Laulederkind SJ, etal., Database (Oxford). 2012 Mar 20;2012:bas016. Print 2012.
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76. Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2. Lee IH, etal., J Biol Chem. 2007 Oct 12;282(41):29866-73. Epub 2007 Aug 22.
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PMID:17030608   PMID:17142780   PMID:17203219   PMID:17241518   PMID:17244606   PMID:17251350   PMID:17272355   PMID:17272774   PMID:17317782   PMID:17371807   PMID:17429605   PMID:17446044  
PMID:17457363   PMID:17475835   PMID:17496209   PMID:17519283   PMID:17545147   PMID:17554339   PMID:17555943   PMID:17562852   PMID:17569669   PMID:17589386   PMID:17622510   PMID:17628541  
PMID:17629454   PMID:17630321   PMID:17630981   PMID:17632284   PMID:17638387   PMID:17654493   PMID:17671970   PMID:17698050   PMID:17728397   PMID:17852410   PMID:17878225   PMID:17885802  
PMID:17891781   PMID:17916612   PMID:17925408   PMID:17942284   PMID:17952604   PMID:17974582   PMID:18037896   PMID:18054038   PMID:18083769   PMID:18097751   PMID:18163231   PMID:18163380  
PMID:18163394   PMID:18182053   PMID:18247380   PMID:18277950   PMID:18292230   PMID:18327702   PMID:18358617   PMID:18366089   PMID:18367451   PMID:18377870   PMID:18379870   PMID:18387192  
PMID:18387957   PMID:18388859   PMID:18410228   PMID:18458087   PMID:18467435   PMID:18483258   PMID:18499741   PMID:18512147   PMID:18534131   PMID:18562309   PMID:18566342   PMID:18593953  
PMID:18615585   PMID:18639865   PMID:18641049   PMID:18663086   PMID:18683242   PMID:18689794   PMID:18757828   PMID:18762576   PMID:18777595   PMID:18838385   PMID:18854312   PMID:18927218  
PMID:18948619   PMID:18975057   PMID:18977203   PMID:19033447   PMID:19039330   PMID:19057511   PMID:19080402   PMID:19082728   PMID:19103588   PMID:19139280   PMID:19147496   PMID:19166928  
PMID:19202327   PMID:19203586   PMID:19208758   PMID:19233842   PMID:19266047   PMID:19298529   PMID:19348060   PMID:19353525   PMID:19356729   PMID:19376806   PMID:19382214   PMID:19422825  
PMID:19457567   PMID:19490361   PMID:19548559   PMID:19570880   PMID:19596798   PMID:19603546   PMID:19626997   PMID:19664625   PMID:19666061   PMID:19667065   PMID:19698760   PMID:19703434  
PMID:19706162   PMID:19709371   PMID:19726745   PMID:19744960   PMID:19778506   PMID:19781178   PMID:19800880   PMID:19816949   PMID:19833727   PMID:19837876   PMID:19850054   PMID:19890275  
PMID:19897600   PMID:19897899   PMID:19911006   PMID:19933931   PMID:19934221   PMID:19936256   PMID:19996110   PMID:19997978   PMID:20011604   PMID:20042608   PMID:20060487   PMID:20093365  
PMID:20168088   PMID:20180400   PMID:20196785   PMID:20332111   PMID:20333297   PMID:20333648   PMID:20368077   PMID:20368999   PMID:20369692   PMID:20383279   PMID:20383584   PMID:20404059  
PMID:20412823   PMID:20432928   PMID:20448149   PMID:20454577   PMID:20466046   PMID:20467782   PMID:20472895   PMID:20492357   PMID:20536329   PMID:20584641   PMID:20607729   PMID:20623292  
PMID:20660299   PMID:20664065   PMID:20665543   PMID:20669351   PMID:20709039   PMID:20724941   PMID:20817061   PMID:20821260   PMID:20830508   PMID:20850791   PMID:20875857   PMID:20878056  
PMID:20923964   PMID:20953735   PMID:20967511   PMID:20973227   PMID:21028992   PMID:21042752   PMID:21045808   PMID:21068199   PMID:21084565   PMID:21090343   PMID:21097843   PMID:21103992  
PMID:21106911   PMID:21182226   PMID:21236345   PMID:21279549   PMID:21321938   PMID:21356360   PMID:21435395   PMID:21443457   PMID:21498085   PMID:21558470   PMID:21567076   PMID:21573888  
PMID:21575352   PMID:21600154   PMID:21607291   PMID:21632956   PMID:21671003   PMID:21683721   PMID:21701583   PMID:21704119   PMID:21712384   PMID:21736902   PMID:21778238   PMID:21784858  
PMID:21784900   PMID:21792084   PMID:21822733   PMID:21862940   PMID:21867737   PMID:21909393   PMID:21940672   PMID:21969871   PMID:21976490   PMID:21984198   PMID:22031698   PMID:22057101  
PMID:22081709   PMID:22104347   PMID:22119396   PMID:22139843   PMID:22158864   PMID:22166507   PMID:22243518   PMID:22272762   PMID:22316281   PMID:22341695   PMID:22374674   PMID:22386689  
PMID:22427704   PMID:22447946   PMID:22487004   PMID:22490886   PMID:22513717   PMID:22537485   PMID:22553040   PMID:22554777   PMID:22568219   PMID:22575563   PMID:22672705   PMID:22750946  
PMID:22771393   PMID:22797923   PMID:22817682   PMID:22910909   PMID:22989604   PMID:22999929   PMID:23031256   PMID:23045700   PMID:23069112   PMID:23073806   PMID:23104384   PMID:23109389  
PMID:23142719   PMID:23167446   PMID:23255243   PMID:23271286   PMID:23330007   PMID:23340251   PMID:23349934   PMID:23419388   PMID:23431171   PMID:23443132   PMID:23457334   PMID:23475611  
PMID:23479225   PMID:23495099   PMID:23520526   PMID:23524257   PMID:23524565   PMID:23524571   PMID:23588401   PMID:23610142   PMID:23702482   PMID:23723063   PMID:23773982   PMID:23781144  
PMID:23785074   PMID:23786676   PMID:23788393   PMID:23793062   PMID:23815272   PMID:23836898   PMID:23871832   PMID:23872169   PMID:23873121   PMID:23920219   PMID:23922853   PMID:23950935  
PMID:23962723   PMID:23965801   PMID:23975404   PMID:24049436   PMID:24090963   PMID:24101522   PMID:24131573   PMID:24169435   PMID:24184018   PMID:24212932   PMID:24303055   PMID:24312696  
PMID:24321547   PMID:24339978   PMID:24342614   PMID:24349482   PMID:24349514   PMID:24390491   PMID:24466133   PMID:24508636   PMID:24553817   PMID:24553818   PMID:24562683   PMID:24577313  
PMID:24675471   PMID:24740015   PMID:24740537   PMID:24742749   PMID:24763696   PMID:24796753   PMID:24875179   PMID:24949428   PMID:24949720   PMID:24988468   PMID:25044177   PMID:25072152  
PMID:25095384   PMID:25139353   PMID:25190803   PMID:25201632   PMID:25217619   PMID:25218191   PMID:25249570   PMID:25268311   PMID:25288788   PMID:25479925   PMID:25484003   PMID:25519685  
PMID:25659151   PMID:25750125   PMID:25757577   PMID:25833759   PMID:25871970   PMID:25874930   PMID:25960234   PMID:26201515   PMID:26251076   PMID:26271595   PMID:26286854   PMID:26296331  
PMID:26303491   PMID:26449460   PMID:26502930   PMID:26514923   PMID:26546817   PMID:26549420   PMID:26558695   PMID:26647727   PMID:26648531   PMID:26674985   PMID:26687945   PMID:26818151  
PMID:26824610   PMID:26824665   PMID:26899247   PMID:26962868   PMID:26992405   PMID:27021411   PMID:27035665   PMID:27035760   PMID:27041232   PMID:27059137   PMID:27068236   PMID:27121731  
PMID:27164497   PMID:27220977   PMID:27264719   PMID:27295130   PMID:27322831   PMID:27372651   PMID:27430327   PMID:27539497   PMID:27606614   PMID:27666568   PMID:27736733   PMID:27748901  
PMID:27766766   PMID:27769787   PMID:27821807   PMID:27843952   PMID:27854077   PMID:27938661   PMID:27941337   PMID:27991911   PMID:28000380   PMID:28173835   PMID:28204829   PMID:28266762  
PMID:28286769   PMID:28290047   PMID:28315454   PMID:28341552   PMID:28412322   PMID:28447730   PMID:28464602   PMID:28566435   PMID:28689409   PMID:28778592   PMID:29042193   PMID:29104511  
PMID:29122977   PMID:29137981   PMID:29152647   PMID:29207050   PMID:29288664   PMID:29294325   PMID:29330129   PMID:29341316   PMID:29351283   PMID:29380557   PMID:29441602   PMID:29488613  
PMID:29572181   PMID:29664021   PMID:29737948   PMID:29786755   PMID:29975930   PMID:30041644   PMID:30053369   PMID:30173372   PMID:30176218   PMID:30195035   PMID:30391592   PMID:30407372  
PMID:30575928   PMID:30660367   PMID:30911955   PMID:31120592   PMID:31219215   PMID:31380437   PMID:31730792   PMID:31759056   PMID:31899964   PMID:31916218   PMID:31995605   PMID:32003536  
PMID:32124939   PMID:32496418   PMID:32678073   PMID:32819597   PMID:33426760   PMID:33559827   PMID:33580994   PMID:33724628   PMID:33748278   PMID:33777313   PMID:33847460   PMID:34080640  
PMID:34288124   PMID:34338399   PMID:34662809   PMID:34663861   PMID:34830353   PMID:35036441   PMID:35093630   PMID:35130772   PMID:35717938   PMID:36091668   PMID:36372121   PMID:36786711  
PMID:36878020   PMID:37157936   PMID:37277581   PMID:37678424   PMID:37702892   PMID:37815888   PMID:37858960   PMID:37863169   PMID:37904673   PMID:38029582   PMID:38063101   PMID:38063104  
PMID:38203304  


Genomics

Comparative Map Data
Akt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86137,534,810 - 137,555,131 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6137,535,390 - 137,552,610 (-)EnsemblGRCr8
mRatBN7.26131,713,716 - 131,735,319 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6131,713,720 - 131,733,921 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6131,883,770 - 131,900,905 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06132,180,876 - 132,197,963 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06131,543,341 - 131,560,403 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06137,218,398 - 137,239,970 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6137,218,376 - 137,236,258 (-)Ensemblrn6Rnor6.0
Rnor_5.06146,225,955 - 146,247,008 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46137,640,482 - 137,657,552 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6129,262,032 - 129,279,096 (-)NCBICelera
RGSC_v3.16137,646,668 - 137,663,739 (-)NCBI
RH 3.4 Map6782.49RGD
Cytogenetic Map6q32NCBI
AKT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814104,769,349 - 104,795,748 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14104,769,348 - 104,799,934 (-)Ensemblhg38GRCh38
GRCh3714105,235,686 - 105,262,085 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3614104,306,731 - 104,333,125 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3414104,306,752 - 104,330,608NCBI
Celera1485,290,760 - 85,317,154 (-)NCBICelera
Cytogenetic Map14q32.33NCBI
HuRef1485,432,617 - 85,464,212 (-)NCBIHuRef
CHM1_114105,173,739 - 105,200,089 (-)NCBICHM1_1
T2T-CHM13v2.01499,012,235 - 99,038,624 (-)NCBIT2T-CHM13v2.0
Akt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912112,620,260 - 112,641,266 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12112,620,255 - 112,641,318 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3812112,653,821 - 112,674,884 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12112,653,821 - 112,674,884 (-)Ensemblmm10GRCm38
MGSCv3712113,892,032 - 113,912,487 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3612113,101,629 - 113,121,998 (-)NCBIMGSCv36mm8
Celera12113,867,449 - 113,888,183 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1261.2NCBI
Akt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555383,208,710 - 3,229,904 (-)Ensembl
ChiLan1.0NW_0049555383,208,711 - 3,224,386 (-)NCBIChiLan1.0ChiLan1.0
AKT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215105,950,803 - 105,978,465 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114105,167,305 - 105,194,960 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01485,417,229 - 85,444,722 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114105,211,645 - 105,236,756 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl14105,208,128 - 105,236,756 (-)EnsemblpanPan2panpan1.1
AKT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1872,317,399 - 72,335,686 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl872,317,869 - 72,335,193 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha871,823,163 - 71,843,039 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0872,592,378 - 72,612,252 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl872,592,384 - 72,609,857 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1872,275,001 - 72,294,850 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0872,318,256 - 72,338,331 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0872,717,834 - 72,737,716 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Akt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086401,791,300 - 1,810,158 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936621620,074 - 639,093 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936621620,163 - 639,115 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AKT1
(Sus scrofa - pig)		 No map positions available.
AKT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12482,704,087 - 82,730,711 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2482,704,068 - 82,727,698 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605370,125,334 - 70,153,468 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Akt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624734509,368 - 525,295 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624734507,880 - 525,295 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Akt1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v17130,247,175 - 130,267,462 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Akt1
227 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:65
Count of miRNA genes:61
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000031164
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6131392689143944780Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat

Markers in Region
RH94769  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26131,714,470 - 131,714,647 (+)MAPPERmRatBN7.2
Rnor_6.06137,219,153 - 137,219,329NCBIRnor6.0
Rnor_5.06146,226,709 - 146,226,885UniSTSRnor5.0
RGSC_v3.46137,640,504 - 137,640,680UniSTSRGSC3.4
Celera6129,262,054 - 129,262,230UniSTS
Cytogenetic Map6q32UniSTS
RH94504  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26131,714,459 - 131,714,541 (+)MAPPERmRatBN7.2
Rnor_6.06137,219,142 - 137,219,223NCBIRnor6.0
Rnor_5.06146,226,698 - 146,226,779UniSTSRnor5.0
RGSC_v3.46137,640,493 - 137,640,574UniSTSRGSC3.4
Celera6129,262,043 - 129,262,124UniSTS
RH 3.4 Map6782.49UniSTS
Cytogenetic Map6q32UniSTS
BE111601  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr86137,537,669 - 137,537,980 (+)Marker Load Pipeline
mRatBN7.26131,716,576 - 131,716,887 (+)MAPPERmRatBN7.2
Rnor_6.06137,221,261 - 137,221,571NCBIRnor6.0
Rnor_5.06146,228,817 - 146,229,127UniSTSRnor5.0
RGSC_v3.46137,642,612 - 137,642,922UniSTSRGSC3.4
Celera6129,264,162 - 129,264,472UniSTS
RH 3.4 Map6783.4UniSTS
Cytogenetic Map6q32UniSTS
PMC312770P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26131,718,480 - 131,719,046 (+)MAPPERmRatBN7.2
Rnor_6.06137,223,165 - 137,223,730NCBIRnor6.0
Rnor_5.06146,230,737 - 146,231,302UniSTSRnor5.0
RGSC_v3.46137,644,516 - 137,645,081UniSTSRGSC3.4
Celera6129,266,060 - 129,266,625UniSTS
Cytogenetic Map6q32UniSTS


Genetic Models
This gene Akt1 is modified in the following models/strains:
SD-Akt1em1Soar    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000031164   ⟹   ENSRNOP00000038369
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6137,535,542 - 137,543,483 (-)Ensembl
mRatBN7.2 Ensembl6131,713,725 - 131,722,390 (-)Ensembl
Rnor_6.0 Ensembl6137,218,376 - 137,236,258 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095849   ⟹   ENSRNOP00000097706
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6137,535,542 - 137,544,001 (-)Ensembl
mRatBN7.2 Ensembl6131,713,725 - 131,722,908 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099722   ⟹   ENSRNOP00000076378
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6137,535,390 - 137,552,610 (-)Ensembl
mRatBN7.2 Ensembl6131,713,720 - 131,733,921 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110155   ⟹   ENSRNOP00000096272
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6137,535,542 - 137,552,610 (-)Ensembl
mRatBN7.2 Ensembl6131,714,449 - 131,731,517 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114705   ⟹   ENSRNOP00000090205
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6137,535,542 - 137,552,610 (-)Ensembl
mRatBN7.2 Ensembl6131,713,725 - 131,720,391 (-)Ensembl
RefSeq Acc Id: NM_033230   ⟹   NP_150233
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,535,542 - 137,552,610 (-)NCBI
mRatBN7.26131,714,449 - 131,731,517 (-)NCBI
Rnor_6.06137,219,131 - 137,236,201 (-)NCBI
Rnor_5.06146,225,955 - 146,247,008 (-)NCBI
RGSC_v3.46137,640,482 - 137,657,552 (-)RGD
Celera6129,262,032 - 129,279,096 (-)RGD
Sequence:
RefSeq Acc Id: XM_039111773   ⟹   XP_038967701
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,534,810 - 137,555,131 (-)NCBI
mRatBN7.26131,713,717 - 131,734,163 (-)NCBI
RefSeq Acc Id: XM_063261541   ⟹   XP_063117611
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,534,810 - 137,554,837 (-)NCBI
Protein Sequences
Protein RefSeqs NP_150233 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967701 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117611 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA06279 (Get FASTA)   NCBI Sequence Viewer  
  EDL97422 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000090205
GenBank Protein P47196 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_150233   ⟸   NM_033230
- UniProtKB: P47196 (UniProtKB/Swiss-Prot),   A6KBV9 (UniProtKB/TrEMBL),   A0A8L2QJ86 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000038369   ⟸   ENSRNOT00000031164
RefSeq Acc Id: XP_038967701   ⟸   XM_039111773
- Peptide Label: isoform X1
- UniProtKB: P47196 (UniProtKB/Swiss-Prot),   A6KBV9 (UniProtKB/TrEMBL),   A0A8L2QJ86 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000097706   ⟸   ENSRNOT00000095849
Ensembl Acc Id: ENSRNOP00000076378   ⟸   ENSRNOT00000099722
Ensembl Acc Id: ENSRNOP00000096272   ⟸   ENSRNOT00000110155
Ensembl Acc Id: ENSRNOP00000090205   ⟸   ENSRNOT00000114705
RefSeq Acc Id: XP_063117611   ⟸   XM_063261541
- Peptide Label: isoform X1
- UniProtKB: P47196 (UniProtKB/Swiss-Prot),   A6KBV9 (UniProtKB/TrEMBL),   A0A8L2QJ86 (UniProtKB/TrEMBL)
Protein Domains
AGC-kinase C-terminal   PH   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P47196-F1-model_v2 AlphaFold P47196 1-480 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2081 AgrOrtholog
BioCyc Gene G2FUF-35781 BioCyc
Ensembl Genes ENSRNOG00000028629 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000114705 ENTREZGENE
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro AGC-kinase_C UniProtKB/Swiss-Prot
  Akt1 UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
  PH_PKB UniProtKB/Swiss-Prot
  Pkinase_C UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:24185 UniProtKB/Swiss-Prot
NCBI Gene 24185 ENTREZGENE
PANTHER RIBOSOMAL PROTEIN S6 KINASE UniProtKB/Swiss-Prot
Pfam PF00169 UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
  Pkinase_C UniProtKB/Swiss-Prot
PharmGKB AKT1 RGD
PhenoGen Akt1 PhenoGen
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot
  PH_DOMAIN UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000028629 RatGTEx
SMART S_TK_X UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
  SM00233 UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
TIGR TC204818
UniProt A0A8I5YBI2_RAT UniProtKB/TrEMBL
  A0A8I6AD70_RAT UniProtKB/TrEMBL
  A0A8I6AQF6_RAT UniProtKB/TrEMBL
  A0A8I6ASB8_RAT UniProtKB/TrEMBL
  A0A8L2QJ86 ENTREZGENE, UniProtKB/TrEMBL
  A6KBV9 ENTREZGENE, UniProtKB/TrEMBL
  AKT1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Akt1  AKT serine/threonine kinase 1  Akt1  v-akt murine thymoma viral oncogene homolog 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Akt1  v-akt murine thymoma viral oncogene homolog 1  Akt1  thymoma viral proto-oncogene 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Akt1  thymoma viral proto-oncogene 1    v-akt murine thymoma viral oncogene homolog 1  Name updated 1299863 APPROVED
2004-12-14 Akt1  v-akt murine thymoma viral oncogene homolog 1      Symbol and Name status set to approved 1299863 APPROVED
2002-06-10 Akt1  v-akt murine thymoma viral oncogene homolog 1      Name updated 70585 PROVISIONAL
2001-03-05 Akt  Murine thymoma viral (v-akt) oncogene homolog 1      Symbol withdrawn, allele of Akt1 (RGD:2081) 61033 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_domains contains a pleckstrin homology domain 632176
gene_domains contains a protein-serine/threonine kinase catalytic domain 632176
gene_expression expressed in testis and other tissues 632176
gene_process may act as a protein-serine/threonine kinase 632176
gene_process may bind protein kinase C 632176
gene_process inhibits JUN kinase activation and reduces JNK mediated apoptosis 632178
gene_protein protein sequence contains 480 amino acids 632176
gene_regulation activity is induced by insulin 632177