GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Akt1 | multiple interactions | EXP | | 6480464 | CTD | [Celecoxib co-treated with sulindac sulfone] results in decreased expression of AKT1 protein; [Celecoxib co-treated with sulindac sulfone] results in decreased expression of AKT1 protein modified form; Celecoxib inhibits the reaction [PDGFA results in increased phosphorylation of and results in increased activity of AKT1 protein] | PMID:17908994 PMID:19201774 | Akt1 | affects phosphorylation | ISO | Akt1 (Mus musculus) | 6480464 | CTD | Celecoxib affects the phosphorylation of AKT1 protein | PMID:15570007 | Akt1 | decreases activity | ISO | AKT1 (Homo sapiens) | 6480464 | CTD | Celecoxib results in decreased activity of AKT1 protein | PMID:17285134 | Akt1 | decreases expression | ISO | AKT1 (Homo sapiens) | 6480464 | CTD | Celecoxib results in decreased expression of AKT1 protein | PMID:14654083 | Akt1 | decreases expression | ISO | Akt1 (Mus musculus) | 6480464 | CTD | Celecoxib results in decreased expression of AKT1 protein | PMID:15570007 | Akt1 | decreases phosphorylation | ISO | AKT1 (Homo sapiens) | 6480464 | CTD | Celecoxib analog results in decreased phosphorylation of AKT1 protein; Celecoxib results in decreased phosphorylation of AKT1 protein | PMID:12000750 PMID:12464646 PMID:15688368 PMID:17257745 | Akt1 | decreases response to substance | ISO | AKT1 (Homo sapiens) | 6480464 | CTD | AKT1 protein results in decreased susceptibility to Celecoxib | PMID:10753955 PMID:19201774 | Akt1 | increases phosphorylation | ISO | AKT1 (Homo sapiens) | 6480464 | CTD | Celecoxib analog results in increased phosphorylation of AKT1 protein; Celecoxib results in increased phosphorylation of AKT1 protein | PMID:15499625 PMID:17270149 | Akt1 | multiple interactions | ISO | AKT1 (Homo sapiens) | 6480464 | CTD | [Atorvastatin co-treated with Celecoxib] results in decreased phosphorylation of AKT1 protein; [Celecoxib co-treated with Docetaxel] results in decreased phosphorylation of AKT1 protein; [Celecoxib co-treated with tetracycline CMT-3] results in decreased phosphorylation of AKT1 protein; Celecoxib inhibits the reaction [PDGFA results in increased phosphorylation of and results in increased activity of AKT1 protein]; Celecoxib results in decreased phosphorylation of and results in decreased activity of AKT1 protein | PMID:10753955 PMID:15688368 PMID:18172863 PMID:19201774 | |
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