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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akt1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:41423
Term: celecoxib
Definition: A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-sulfamoylphenyl, trifluoromethyl and p-tolyl groups, respectively. A cyclooxygenase-2 inhibitor, it is used in the treatment of arthritis.
Chemical ID: MESH:C105934
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1multiple interactionsEXP 6480464CTD[Celecoxib co-treated with sulindac sulfone] results in decreased expression of AKT1 protein; [Celecoxib co-treated with sulindac sulfone] results in decreased expression of AKT1 protein modified form; Celecoxib inhibits the reaction [PDGFA results in increased phosphorylation of and results in increased activity of AKT1 protein]PMID:17908994 PMID:19201774
Akt1affects phosphorylationISOAkt1 (Mus musculus)6480464CTDCelecoxib affects the phosphorylation of AKT1 proteinPMID:15570007
Akt1decreases activityISOAKT1 (Homo sapiens)6480464CTDCelecoxib results in decreased activity of AKT1 proteinPMID:17285134
Akt1decreases expressionISOAKT1 (Homo sapiens)6480464CTDCelecoxib results in decreased expression of AKT1 proteinPMID:14654083
Akt1decreases expressionISOAkt1 (Mus musculus)6480464CTDCelecoxib results in decreased expression of AKT1 proteinPMID:15570007
Akt1decreases phosphorylationISOAKT1 (Homo sapiens)6480464CTDCelecoxib analog results in decreased phosphorylation of AKT1 protein; Celecoxib results in decreased phosphorylation of AKT1 proteinPMID:12000750 PMID:12464646 PMID:15688368 PMID:17257745
Akt1decreases response to substanceISOAKT1 (Homo sapiens)6480464CTDAKT1 protein results in decreased susceptibility to CelecoxibPMID:10753955 PMID:19201774
Akt1increases phosphorylationISOAKT1 (Homo sapiens)6480464CTDCelecoxib analog results in increased phosphorylation of AKT1 protein; Celecoxib results in increased phosphorylation of AKT1 proteinPMID:15499625 PMID:17270149
Akt1multiple interactionsISOAKT1 (Homo sapiens)6480464CTD[Atorvastatin co-treated with Celecoxib] results in decreased phosphorylation of AKT1 protein; [Celecoxib co-treated with Docetaxel] results in decreased phosphorylation of AKT1 protein; [Celecoxib co-treated with tetracycline CMT-3] results in decreased phosphorylation of AKT1 protein; Celecoxib inhibits the reaction [PDGFA results in increased phosphorylation of and results in increased activity of AKT1 protein]; Celecoxib results in decreased phosphorylation of and results in decreased activity of AKT1 proteinPMID:10753955 PMID:15688368 PMID:18172863 PMID:19201774
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