Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akt1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:52289
Term: wortmannin
Definition: A delta-lactone that has formula C23H24O8.
Chemical ID: MESH:C009687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1decreases reactionEXP 152177689RGDwortmannin inhibits the reaction [estrogen increases phosphorylation of Akt1 protein] in rat uterus 
Akt1decreases phosphorylationEXP 6480464CTDwortmannin results in decreased phosphorylation of AKT1 proteinPMID:26437446
Akt1multiple interactionsEXP 6480464CTDWortmannin inhibits the reaction [1,1-dimethylbutyl-1-deoxy-Delta(9)-THC inhibits the reaction [Magnesium deficiency results in decreased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [astringin results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [chaetoglobosins results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [GRK2 protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [GRN protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [hydroxyflutamide results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [INS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [linsidomine results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [NGF protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Peroxynitrous Acid results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of AKT1 mRNA]]; Wortmannin inhibits the reaction [Resveratrol results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Taurocholic Acid inhibits the reaction [Carbon Tetrachloride results in decreased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [Taurolithocholic Acid results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Thapsigargin results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Tunicamycin results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of AKT1 protein]PMID:11306697 PMID:12388182 PMID:15849355 PMID:16825486 PMID:17302912 PMID:17324588 PMID:17346750 PMID:17728140 PMID:17962351 PMID:18040759 PMID:18317400 PMID:19810018 PMID:20100827 PMID:21195169 PMID:21820214 PMID:22022464 PMID:24462917 PMID:25398788 PMID:26437446 PMID:28759639 PMID:30542433 PMID:31300867 PMID:32805344
Akt1decreases activityISOAKT1 (Homo sapiens)6480464CTDwortmannin results in decreased activity of AKT1 proteinPMID:12556562
Akt1decreases expressionISOAkt1 (Mus musculus)6480464CTDwortmannin results in decreased expression of AKT1 proteinPMID:15695173 PMID:17129604
Akt1decreases phosphorylationISOAKT1 (Homo sapiens)6480464CTDWortmannin results in decreased phosphorylation of AKT1 proteinPMID:12640124 PMID:16059913 PMID:23178381 PMID:25663935 PMID:31445927
Akt1decreases phosphorylationISOAkt1 (Mus musculus)6480464CTDwortmannin results in decreased phosphorylation of AKT1 proteinPMID:12032135 PMID:17129604 PMID:20880397 PMID:22137261 PMID:23145070 PMID:25603053
Akt1multiple interactionsISOAKT1 (Homo sapiens)6480464CTDAKT1 protein modified form inhibits the reaction [Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of CASP3 protein]]; AKT1 protein modified form inhibits the reaction [Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein]]; AKT1 protein modified form inhibits the reaction [Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased expression of MCL1 protein]]; Wortmannin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [4,4'-hexafluorisopropylidene diphenol results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [4-hydroxyestradiol results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased activity of and results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [[[MPO protein co-treated with Chlorides co-treated with Threonine co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Acrolein] which results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [arsenite results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [baicalein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [C5 protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Caffeine results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Camptothecin results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Capsaicin results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Copper results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [Copper Sulfate results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [CXCL8 results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Estrone results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [Hexanones results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Humic Substances results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Hydrocarbons, Chlorinated results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [ochratoxin A results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Simvastatin promotes the reaction [[Nifedipine co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [tetrachlorodian results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Trp-Lys-Tyr-Met-Val-Met results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Zinc results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Zinc results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin promotes the reaction [evodiamine results in decreased phosphorylation of AKT1 protein]PMID:11788791 PMID:12482858 PMID:12614848 PMID:14757120 PMID:15050414 PMID:15177934 PMID:15355987 PMID:15608143 PMID:15980035 PMID:16116186 PMID:16499871 PMID:16682453 PMID:16973122 PMID:17513037 PMID:17520698 PMID:17550345 PMID:18025287 PMID:18201823 PMID:19139269 PMID:19686714 PMID:19801633 PMID:20005289 PMID:20153296 PMID:20562903 PMID:21742513 PMID:21767602 PMID:22556157 PMID:23001822 PMID:24024143 PMID:24748653 PMID:25002221 PMID:26262998 PMID:30590302 PMID:30851366 PMID:31173752 PMID:32802178 PMID:33582643 PMID:34077701 PMID:34144024 PMID:37051183
Akt1multiple interactionsISOAkt1 (Mus musculus)6480464CTDResveratrol promotes the reaction [Wortmannin results in decreased phosphorylation of AKT1 protein]; Thimerosal promotes the reaction [Wortmannin results in decreased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [4-hydroxyisoleucine inhibits the reaction [TNF protein results in decreased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [cyanoginosin LR results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [INS1 protein results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [zinc chloride results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of AKT1 protein]; Wortmannin promotes the reaction [Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]]; Wortmannin promotes the reaction [Resveratrol results in decreased phosphorylation of AKT1 protein]; Wortmannin promotes the reaction [Thimerosal results in decreased phosphorylation of AKT1 protein]; Wortmannin results in decreased activity of and results in decreased phosphorylation of AKT1 proteinPMID:11340092 PMID:15178407 PMID:15845746 PMID:16224792 PMID:17464197 PMID:18591783 PMID:18948619 PMID:20880397 PMID:21138475 PMID:22137261 PMID:23145070 PMID:25461906 PMID:25603053 PMID:26887316 PMID:36288207
Go Back to source page   Continue to Ontology report