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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akt1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1decreases expressionEXP 6480464CTDOzone results in decreased expression of AKT1 mRNAPMID:33217375
Akt1multiple interactionsEXP 6480464CTD[Olive Oil co-treated with Ozone] results in increased expression of AKT1 mRNA; [Ozone co-treated with Chlorine] results in increased expression of AKT1 mRNAPMID:18636392 PMID:33217375
Akt1increases expressionISOAkt1 (Mus musculus)6480464CTDOzone results in increased expression of AKT1 proteinPMID:26949510
Akt1increases phosphorylationISOAKT1 (Homo sapiens)6480464CTDOzone results in increased phosphorylation of AKT1 proteinPMID:19536146
Akt1multiple interactionsISOAKT1 (Homo sapiens)6480464CTD[Air Pollutants results in increased abundance of Ozone] which affects the expression of AKT1 mRNA; [Oxygen co-treated with Ozone co-treated with Cannabidiol] results in decreased expression of AKT1 mRNA; [Oxygen co-treated with Ozone] results in decreased expression of AKT1 mRNAPMID:32992648 PMID:35430440
Akt1multiple interactionsISOAkt1 (Mus musculus)6480464CTDOzone promotes the reaction [Soot results in increased phosphorylation of AKT1 protein]PMID:27570198
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