RGD Reference Report - Dissociation of Akt/PKB and ribosomal S6 kinase signaling markers in a transgenic mouse model of Alzheimer's disease. - Rat Genome Database

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Dissociation of Akt/PKB and ribosomal S6 kinase signaling markers in a transgenic mouse model of Alzheimer's disease.

Authors: Damjanac, M  Rioux Bilan, A  Paccalin, M  Pontcharraud, R  Fauconneau, B  Hugon, J  Page, G 
Citation: Damjanac M, etal., Neurobiol Dis. 2008 Feb;29(2):354-67. Epub 2007 Oct 11.
RGD ID: 5509085
Pubmed: PMID:18023354   (View Abstract at PubMed)
DOI: DOI:10.1016/j.nbd.2007.09.008   (Journal Full-text)

Previous studies demonstrated that the PKR (double-stranded RNA-activated protein kinase) pathway was activated while the mTOR (mammalian target of rapamycin) pathway was inhibited in Alzheimer's disease (AD). Here, we analysed upstream and downstream factors of mTOR in brain of APP(SL)/PS1 KI mice displaying a massive neuronal loss in hippocampus. While mTOR levels were not modified, we found a great activation of Akt with a robust accumulation of P-Akt((T308)) in non-apoptotic neurons at 6 months of age. At the opposite, a significant decrease of the p70/85S6K activation was observed in brain of PS1 KI and APP(SL)/PS1 KI mice with a very weak or no nucleocytoplasmic P-p70/85S6K((T389)) staining in apoptotic neurons of APP(SL)/PS1 KI mice. Furthermore, the activation of Erk1/2, 4E-BP1 and p70S6K((T421/S424)) (substrate of Erk1/2), except eIF4E, was not modified. These findings demonstrate a clear dissociation between Akt and ribosomal S6K signaling markers in these mice which could be involved in the AD pathological process.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
AKT1HumanAlzheimer's disease  ISOAkt1 (Mus musculus)protein:increased tyrosine phosphorylation:cerebral cortexRGD 
Akt1RatAlzheimer's disease  ISOAkt1 (Mus musculus)protein:increased tyrosine phosphorylation:cerebral cortexRGD 
Akt1MouseAlzheimer's disease  IEP protein:increased tyrosine phosphorylation:cerebral cortexRGD 

Objects Annotated

Genes (Rattus norvegicus)
Akt1  (AKT serine/threonine kinase 1)

Genes (Mus musculus)
Akt1  (thymoma viral proto-oncogene 1)

Genes (Homo sapiens)
AKT1  (AKT serine/threonine kinase 1)


Additional Information