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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akt1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:9546
Term: thimerosal
Definition: An alkylmercury compound (approximately 49% mercury by weight) used as an antiseptic and antifungal agent.
Chemical ID: MESH:D013849
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1decreases phosphorylationISOAkt1 (Mus musculus)6480464CTDThimerosal results in decreased phosphorylation of AKT1 proteinPMID:23145070
Akt1multiple interactionsISOAkt1 (Mus musculus)6480464CTDThimerosal promotes the reaction [wortmannin results in decreased phosphorylation of AKT1 protein]; wortmannin promotes the reaction [Thimerosal results in decreased phosphorylation of AKT1 protein]PMID:23145070
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