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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akt1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:310312
Term: isoliquiritigenin
Definition: A member of the class of chalcones that is trans-chalcone hydroxylated at C-2', -4 and -4'.
Chemical ID: MESH:C040920
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1decreases phosphorylationISORGD:7329096480464CTDisoliquiritigenin results in decreased phosphorylation of AKT1 protein

PMID:23747687, PMID:25094029
Akt1decreases response to substanceISORGD:7329096480464CTDAKT1 protein modified form results in decreased susceptibility to isoliquiritigenin

PMID:23747687, PMID:25094029
Akt1multiple interactionsISORGD:7329096480464CTD20-hydroxyeicosa-5(Z), 14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased activity of AKT1 protein], 20-hydroxyeicosa-5(Z), 14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased phosphorylation of and results in decreased activity of AKT1 protein], AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA], AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein], AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA], AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein], AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein], AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein], CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased phosphorylation of and results in decreased activity of AKT1 protein], Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased activity of AKT1 protein], Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased phosphorylation of and results in decreased activity of AKT1 protein], isoliquiritigenin results in decreased phosphorylation of and results in decreased activity of AKT1 protein, Leukotriene B4 inhibits the reaction [isoliquiritigenin results in decreased activity of AKT1 protein]

PMID:23747687, PMID:25094029
Akt1multiple interactionsISORGD:7353366480464CTDisoliquiritigenin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]

PMID:27117918
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.