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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akt1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:38725
Term: mevinphos
Definition: An organophosphate insecticide that has formula C7H13O6P.
Chemical ID: MESH:D008799
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1increases phosphorylationEXP 6480464CTDMevinphos results in increased phosphorylation of AKT1 protein

PMID:25449601
Akt1multiple interactionsEXP 6480464CTD2-4-morpholinyl-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein] AKT1 protein modified form affects the reaction [Mevinphos results in increased activity of RELA protein] Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein PI103 inhibits the reaction [Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein] Wortmannin inhibits the reaction [Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein]

PMID:24462917
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