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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akt1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:35176
Term: zinc sulfate
Definition: A metal sulfate compound having zinc(2+) as the counterion.
Chemical ID: MESH:D019287
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1increases phosphorylationEXP 6480464CTDZinc Sulfate results in increased phosphorylation of AKT1 proteinPMID:20100827
Akt1multiple interactionsEXP 6480464CTDRTKI cpd inhibits the reaction [Zinc Sulfate results in increased phosphorylation of AKT1 protein]; tyrphostin AG 1024 inhibits the reaction [Zinc Sulfate results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of AKT1 protein]PMID:19946718 PMID:20100827
Akt1increases phosphorylationISOAKT1 (Homo sapiens)6480464CTDZinc Sulfate results in increased phosphorylation of AKT1 proteinPMID:15355987 PMID:19946718
Akt1increases phosphorylationISOAkt1 (Mus musculus)6480464CTDZinc Sulfate results in increased phosphorylation of AKT1 proteinPMID:16224792
Akt1multiple interactionsISOAKT1 (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc Sulfate results in increased phosphorylation of and results in increased activity of AKT1 protein]; IGF1R mutant form inhibits the reaction [Zinc Sulfate results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of and results in increased activity of AKT1 protein]; Zinc Sulfate results in increased phosphorylation of and results in increased activity of AKT1 proteinPMID:15355987 PMID:16973122 PMID:19946718
Akt1multiple interactionsISOAkt1 (Mus musculus)6480464CTDwortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of AKT1 protein]PMID:16224792
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