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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akt1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:83267
Term: filipin III
Definition: A macrolide that is the major component of a mixture of four isomeric polyene macrolides isolated from Streptomyces filipinensis.
Chemical ID: MESH:D005372
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1multiple interactionsEXP 6480464CTDFilipin inhibits the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein] Filipin inhibits the reaction [Iron results in increased phosphorylation of AKT1 protein]

PMID:17172471
Akt1multiple interactionsISORGD:7329096480464CTDFilipin inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein]

PMID:12614848
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