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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akt1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:40303
Term: lovastatin
Definition: A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as an anticholesteremic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom).
Chemical ID: MESH:D008148
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1decreases phosphorylationEXP 6480464CTDLovastatin results in decreased phosphorylation of AKT1 proteinPMID:20578043
Akt1multiple interactionsEXP 6480464CTDLovastatin inhibits the reaction [Cholesterol, Dietary results in decreased expression of AKT1 protein]PMID:35734936
Akt1decreases phosphorylationISOAKT1 (Homo sapiens)6480464CTDLovastatin results in decreased phosphorylation of AKT1 proteinPMID:16425225 PMID:17472962
Akt1multiple interactionsISOAKT1 (Homo sapiens)6480464CTDLovastatin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]PMID:19760159
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