GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Akt1 | decreases expression | ISO | Akt1 (Mus musculus) | 6480464 | CTD | Olanzapine results in decreased expression of AKT1 mRNA | PMID:32652086 | Akt1 | increases expression | ISO | AKT1 (Homo sapiens) | 6480464 | CTD | Olanzapine results in increased expression of AKT1 mRNA; Olanzapine results in increased expression of AKT1 protein | PMID:19440698 | Akt1 | increases phosphorylation | ISO | AKT1 (Homo sapiens) | 6480464 | CTD | olanzapine results in increased phosphorylation of AKT1 protein | PMID:19440698 | Akt1 | increases response to substance | ISO | AKT1 (Homo sapiens) | 6480464 | CTD | AKT1 gene SNP results in increased susceptibility to olanzapine | PMID:21187413 | Akt1 | multiple interactions | ISO | Akt1 (Mus musculus) | 6480464 | CTD | capsazepine inhibits the reaction [Olanzapine results in decreased expression of AKT1 mRNA]; Metformin inhibits the reaction [Olanzapine results in decreased expression of AKT1 mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of AKT1 mRNA] | PMID:32652086 | |
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