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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akt1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1decreases phosphorylationEXP 6480464CTDresveratrol results in decreased phosphorylation of AKT1 proteinPMID:24304514 PMID:26283207
Akt1increases phosphorylationEXP 6480464CTDResveratrol results in increased phosphorylation of AKT1 proteinPMID:17188708 PMID:17346750 PMID:31433112
Akt1multiple interactionsEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of AKT1 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cadmium Chloride results in decreased phosphorylation of AKT1 protein]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol results in increased phosphorylation of AKT1 protein]; [Resveratrol co-treated with Pravastatin] results in increased phosphorylation of AKT1 protein; [Resveratrol co-treated with Streptozocin] results in decreased phosphorylation of AKT1 protein; Resveratrol inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [Cadmium Chloride results in decreased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [Glucose results in increased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [Sirolimus results in increased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [Streptozocin results in decreased expression of AKT1 mRNA]; Resveratrol results in decreased phosphorylation of and results in decreased activity of AKT1 protein; Resveratrol results in increased phosphorylation of and results in increased activity of AKT1 protein; Wortmannin inhibits the reaction [Resveratrol results in increased phosphorylation of AKT1 protein]PMID:15849355 PMID:15882976 PMID:16626303 PMID:16860989 PMID:17188708 PMID:17346750 PMID:17550345 PMID:24304514 PMID:24971582 PMID:25471227 PMID:26071184 PMID:26283207 PMID:31433112
Akt1affects bindingISOAKT1 (Homo sapiens)6480464CTDresveratrol binds to AKT1 proteinPMID:24968355
Akt1affects phosphorylationISOAKT1 (Homo sapiens)6480464CTDresveratrol affects the phosphorylation of AKT1 proteinPMID:24001813
Akt1decreases activityISOAKT1 (Homo sapiens)6480464CTDresveratrol results in decreased activity of AKT1 proteinPMID:23229870
Akt1decreases expressionISOAKT1 (Homo sapiens)6480464CTDresveratrol results in decreased expression of AKT1 mRNA; resveratrol results in decreased expression of AKT1 protein; resveratrol results in decreased expression of AKT1 protein modified formPMID:22234583 PMID:23314035 PMID:24299158 PMID:24968355
Akt1decreases phosphorylationISOAKT1 (Homo sapiens)6480464CTDResveratrol results in decreased phosphorylation of AKT1 proteinPMID:15829497 PMID:16731767 PMID:16979140 PMID:17044934 PMID:17164350 PMID:17486135 PMID:17823925 PMID:21743969 PMID:21980390 PMID:23954321 PMID:23975182 PMID:24535223 PMID:25448084 PMID:25605016 PMID:26394120 PMID:26530632 PMID:32621571
Akt1decreases phosphorylationISOAkt1 (Mus musculus)6480464CTDresveratrol results in decreased phosphorylation of AKT1 proteinPMID:21980390 PMID:22137261 PMID:23525482 PMID:24304514 PMID:25603053
Akt1increases phosphorylationISOAKT1 (Homo sapiens)6480464CTDresveratrol results in increased phosphorylation of AKT1 proteinPMID:17499741 PMID:23298290 PMID:27049278
Akt1multiple interactionsISOAKT1 (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of AKT1 protein]; [Resveratrol binds to NQO2 protein] inhibits the reaction [NQO2 protein binds to AKT1 protein]; CBX7 protein inhibits the reaction [Resveratrol results in decreased phosphorylation of AKT1 protein]; MIR21 mRNA inhibits the reaction [Resveratrol results in decreased phosphorylation of AKT1 protein]; MRK 003 affects the reaction [Resveratrol results in decreased phosphorylation of AKT1 protein]; NQO2 protein inhibits the reaction [Resveratrol results in decreased expression of AKT1 protein]; PTEN protein affects the reaction [Resveratrol results in decreased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [AKT1 protein binds to NQO2 protein]; Resveratrol inhibits the reaction [AKT1 protein results in increased phosphorylation of FOXO1 protein]; Resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of AKT1 mRNA]; Resveratrol inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Resveratrol inhibits the reaction [PIK3CA protein results in increased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [Pyruvaldehyde results in decreased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [Sirolimus results in increased phosphorylation of AKT1 protein]; Resveratrol results in decreased phosphorylation of and results in decreased activity of AKT1 proteinPMID:15925284 PMID:16343977 PMID:16626303 PMID:17513867 PMID:17550345 PMID:17868649 PMID:20153296 PMID:21743969 PMID:22917016 PMID:23452621 PMID:24304514 PMID:24535223 PMID:24968355 PMID:26497626 PMID:26530632 PMID:27049278 PMID:32621571
Akt1multiple interactionsISOAkt1 (Mus musculus)6480464CTD6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein]]; [Resveratrol results in increased activity of SIRT1 protein] which results in increased phosphorylation of and results in increased activity of AKT1 protein; [Sirolimus co-treated with Resveratrol] promotes the reaction [TSC2 gene mutant form results in decreased phosphorylation of AKT1 protein]; PRKAA2 protein affects the reaction [Resveratrol results in decreased phosphorylation of AKT1 protein]; PTPN11 protein affects the reaction [Resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]]; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with TLR4] results in increased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [Dietary Fats results in decreased expression of AKT1 mRNA]; Resveratrol inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [FGF2 protein results in increased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]; Resveratrol promotes the reaction [TSC2 gene mutant form results in decreased phosphorylation of AKT1 protein]; Resveratrol promotes the reaction [Wortmannin results in decreased phosphorylation of AKT1 protein]; Sirolimus inhibits the reaction [Resveratrol results in decreased phosphorylation of AKT1 protein]; SIRT1 protein affects the reaction [Resveratrol results in decreased phosphorylation of AKT1 protein]; sirtinol inhibits the reaction [Resveratrol inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein]]; Wortmannin promotes the reaction [Resveratrol results in decreased phosphorylation of AKT1 protein]PMID:15849355 PMID:20370652 PMID:22118570 PMID:22137261 PMID:24304514 PMID:25290095 PMID:25603053 PMID:26450947 PMID:27260466 PMID:27279585
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