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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akt1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1decreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of AKT1 mRNAPMID:34037972
Akt1multiple interactionsEXP 6480464CTDArsenic Trioxide results in decreased expression of and results in decreased phosphorylation of AKT1 protein; Phloretin inhibits the reaction [Arsenic Trioxide results in decreased expression of AKT1 mRNA]; trans-sodium crocetinate inhibits the reaction [Arsenic Trioxide results in decreased expression of and results in decreased phosphorylation of AKT1 protein]PMID:32919218 PMID:34037972
Akt1affects stabilityISOAKT1 (Homo sapiens)6480464CTDArsenic Trioxide affects the stability of AKT1 proteinPMID:18566239
Akt1decreases expressionISOAKT1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of AKT1 mRNA; Arsenic Trioxide results in decreased expression of AKT1 proteinPMID:20458559 PMID:30093655
Akt1decreases expressionISOAkt1 (Mus musculus)6480464CTDArsenic Trioxide results in decreased expression of AKT1 mRNAPMID:30032600 PMID:30225639
Akt1decreases phosphorylationISOAKT1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased phosphorylation of AKT1 proteinPMID:16434995 PMID:20657188 PMID:21594580 PMID:21655183 PMID:25449439 PMID:30362509 PMID:32305283
Akt1decreases phosphorylationISOAkt1 (Mus musculus)6480464CTDArsenic Trioxide results in decreased phosphorylation of AKT1 proteinPMID:20299303 PMID:30362509 PMID:33462182
Akt1decreases response to substanceISOAKT1 (Homo sapiens)6480464CTDAKT1 protein results in decreased susceptibility to Arsenic Trioxide; AKT1 results in decreased susceptibility to Arsenic TrioxidePMID:16115127 PMID:18048359 PMID:18566239 PMID:21655183
Akt1increases activityISOAKT1 (Homo sapiens)6480464CTDArsenic Trioxide results in increased activity of AKT1 proteinPMID:19457607
Akt1increases phosphorylationISOAKT1 (Homo sapiens)6480464CTDArsenic Trioxide results in increased phosphorylation of AKT1 proteinPMID:25791921 PMID:29266867 PMID:35714947
Akt1increases phosphorylationISOAkt1 (Mus musculus)6480464CTDArsenic Trioxide results in increased phosphorylation of AKT1 proteinPMID:15688020 PMID:21078540
Akt1multiple interactionsISOAKT1 (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Arsenic Trioxide results in decreased phosphorylation of AKT1 protein]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of AKT1 protein]; [AKT1 protein co-treated with 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole] inhibits the reaction [Arsenic Trioxide results in decreased expression of MCL1 protein]; [Arsenic Trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of AKT1 protein; [Arsenic Trioxide results in increased expression of BCL2L11 protein] which results in decreased phosphorylation of AKT1 protein; [aspartyl-glutamyl-valyl-aspartal results in decreased activity of CASP3 protein] inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of AKT1 protein]; [Bortezomib results in decreased activity of CBL protein] promotes the reaction [Arsenic Trioxide results in increased activity of AKT1 protein]; [Sirolimus co-treated with Arsenic Trioxide] results in decreased phosphorylation of AKT1 protein; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased activity of AKT1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of AKT1 protein]; AKT1 mutant form promotes the reaction [Arsenic Trioxide results in increased cleavage of CASP3 protein]; AKT1 mutant form promotes the reaction [Arsenic Trioxide results in increased cleavage of CASP9 protein]; AKT1 protein affects the reaction [Arsenic Trioxide affects the localization of SLC2A1 protein]; AKT1 protein affects the reaction [Arsenic Trioxide results in increased expression of CCND1 protein]; AKT1 protein affects the reaction [Arsenic Trioxide results in increased expression of CDC6 protein]; AKT1 protein inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of GSK3B protein]; AKT1 protein inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK1 protein]; AKT1 protein inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK3 protein]; AKT1 protein promotes the reaction [Arsenic Trioxide results in increased expression of TGIF1 mRNA]; Arsenic Trioxide affects the reaction [temsirolimus results in increased phosphorylation of AKT1 protein]; Arsenic Trioxide inhibits the reaction [AKT1 protein binds to MAPK8IP1 protein]; Arsenic Trioxide inhibits the reaction [lonidamine results in increased phosphorylation of AKT1 protein]; Arsenic Trioxide inhibits the reaction [Sirolimus results in increased phosphorylation of AKT1 protein]; Arsenic Trioxide inhibits the reaction [TGFB1 protein results in increased phosphorylation of AKT1 protein]; Arsenic Trioxide promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein]; Arsenic Trioxide promotes the reaction [AKT1 protein binds to PPP2CA protein]; Arsenic Trioxide promotes the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; Arsenic Trioxide promotes the reaction [tanespimycin results in decreased expression of AKT1 protein]; Arsenic Trioxide promotes the reaction [Tretinoin results in decreased expression of AKT1 protein]; Arsenic Trioxide results in decreased activity of and results in decreased expression of AKT1 protein; Arsenic Trioxide results in decreased phosphorylation of and results in decreased activity of AKT1 protein; Arsenic Trioxide results in increased phosphorylation of and results in increased activity of AKT1 protein; aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Arsenic Trioxide promotes the reaction [AKT1 protein binds to PPP2CA protein]]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Arsenic Trioxide results in decreased expression of AKT1 protein]; Genistein inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of AKT1 protein]; MAPK8 protein affects the reaction [Arsenic Trioxide results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; NSC 680410 promotes the reaction [Arsenic Trioxide results in decreased phosphorylation of AKT1 protein]; Okadaic Acid inhibits the reaction [Arsenic Trioxide promotes the reaction [AKT1 protein binds to PPP2CA protein]]; Okadaic Acid inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of AKT1 protein]; Palmitic Acid inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of AKT1 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; Rosiglitazone inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of AKT1 protein]; setanaxib inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of AKT1 protein]; tanespimycin promotes the reaction [Arsenic Trioxide results in decreased expression of AKT1 protein]; Taurine inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of AKT1 protein]; Tretinoin promotes the reaction [Arsenic Trioxide results in decreased expression of AKT1 protein]PMID:12168106 PMID:16882451 PMID:17077332 PMID:18566239 PMID:19457607 PMID:20200477 PMID:20534739 PMID:20605902 PMID:20657188 PMID:20862710 PMID:21078540 PMID:21594580 PMID:21649584 PMID:21655183 PMID:21889928 PMID:24392034 PMID:24762191 PMID:25758096 PMID:25791921 PMID:30093655 PMID:30362509 PMID:32305283 PMID:35714947
Akt1multiple interactionsISOAkt1 (Mus musculus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Arsenic Trioxide results in decreased phosphorylation of AKT1 protein]; Arsenic Trioxide inhibits the reaction [AKT1 protein binds to PPARG protein]; Arsenic Trioxide inhibits the reaction [Glycerol results in increased phosphorylation of AKT1 protein]; Arsenic Trioxide promotes the reaction [Reserpine results in decreased phosphorylation of AKT1 protein]; Arsenic Trioxide results in increased expression of and results in increased phosphorylation of AKT1 protein; Genistein inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of AKT1 protein]; Taurine inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of AKT1 protein]PMID:15916724 PMID:20299303 PMID:21078540 PMID:26114099 PMID:30362509 PMID:33462182
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