Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akt1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1decreases phosphorylationEXP 6480464CTDParaquat results in decreased phosphorylation of AKT1 proteinPMID:36394833
Akt1affects phosphorylationISOAKT1 (Homo sapiens)6480464CTDParaquat affects the phosphorylation of AKT1 proteinPMID:28428137
Akt1affects phosphorylationISOAkt1 (Mus musculus)6480464CTDParaquat affects the phosphorylation of AKT1 proteinPMID:28428137
Akt1decreases expressionISOAKT1 (Homo sapiens)6480464CTDParaquat results in decreased expression of AKT1 mRNAPMID:31966674
Akt1decreases expressionISOAkt1 (Mus musculus)6480464CTDParaquat results in decreased expression of AKT1 mRNAPMID:16797015 PMID:30744607
Akt1decreases phosphorylationISOAKT1 (Homo sapiens)6480464CTDParaquat results in decreased phosphorylation of AKT1 proteinPMID:31966674
Akt1decreases phosphorylationISOAkt1 (Mus musculus)6480464CTDParaquat results in decreased phosphorylation of AKT1 proteinPMID:30744607 PMID:34863858
Akt1multiple interactionsISOAKT1 (Homo sapiens)6480464CTDARL6IP5 protein affects the reaction [Paraquat affects the phosphorylation of AKT1 protein]; DNAJC3 protein inhibits the reaction [Paraquat results in decreased expression of AKT1 mRNA]; DNAJC3 protein inhibits the reaction [Paraquat results in decreased phosphorylation of AKT1 protein]PMID:28428137 PMID:31966674
Akt1multiple interactionsISOAkt1 (Mus musculus)6480464CTD[Maneb co-treated with Paraquat] results in decreased expression of AKT1 mRNA; AKT1 protein affects the reaction [Paraquat results in decreased expression of BCL2 protein]; AKT1 protein affects the reaction [Paraquat results in increased activity of CASP3 protein]; AKT1 protein affects the reaction [Paraquat results in increased expression of BAX protein]; ARL6IP5 protein affects the reaction [Paraquat affects the phosphorylation of AKT1 protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of AKT1 mRNA]; MIR193A mRNA inhibits the reaction [Paraquat results in decreased phosphorylation of AKT1 protein]; Paraquat results in increased expression of and results in decreased phosphorylation of AKT1 protein; Paraquat results in increased expression of and results in increased phosphorylation of AKT1 protein; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of AKT1 mRNA]; tetramethylpyrazine inhibits the reaction [Paraquat results in decreased expression of AKT1 mRNA]; tetramethylpyrazine inhibits the reaction [Paraquat results in decreased phosphorylation of AKT1 protein]PMID:23898955 PMID:23963992 PMID:28115273 PMID:28428137 PMID:30744607 PMID:34863858
Go Back to source page   Continue to Ontology report