GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Akt1 | decreases phosphorylation | ISO | AKT1 (Homo sapiens) | 151357000 | RGD | osimertinib decreases phosphorylation of AKT1 protein in lung | | Akt1 | decreases phosphorylation | ISO | AKT1 (Homo sapiens) | 6480464 | CTD | osimertinib results in decreased phosphorylation of AKT1 protein | PMID:36807944 | Akt1 | multiple interactions | ISO | AKT1 (Homo sapiens) | 6480464 | CTD | osimertinib affects the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; osimertinib inhibits the reaction [Derp2 allergen, Dermatophagoides pteronyssinus results in increased phosphorylation of AKT1 protein]; osimertinib results in decreased expression of and results in decreased phosphorylation of AKT1 protein | PMID:30145802 PMID:30623574 PMID:30993382 | |
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