RGD Reference Report - Positive association of AKT1 haplotype to Japanese methamphetamine use disorder. - Rat Genome Database

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Positive association of AKT1 haplotype to Japanese methamphetamine use disorder.

Authors: Ikeda, Masashi  Iwata, Nakao  Suzuki, Tatsuyo  Kitajima, Tsuyoshi  Yamanouchi, Yoshio  Kinoshiya, Yoko  Sekine, Yoshimoto  Iyo, Masaomi  Harano, Mutsuo  Komiyama, Tokutaro  Yamada, Mitsuhiko  Sora, Ichiro  Ujike, Hiroshi  Inada, Toshiya  Ozaki, Norio 
Citation: Ikeda M, etal., Int J Neuropsychopharmacol. 2006 Feb;9(1):77-81. doi: 10.1017/S1461145705005481. Epub 2005 Jun 28.
RGD ID: 407419878
Pubmed: PMID:15982448   (View Abstract at PubMed)
DOI: DOI:10.1017/S1461145705005481   (Journal Full-text)

Recent evidence suggests that the AKT1-GSK3beta signalling cascade partially mediates dopamine-dependent behaviours. In relation to the pathophysiology of schizophrenia or methamphetamine (Meth) use disorder, AKT1 is a good candidate gene for such conditions. For schizophrenia, positive associations of SNPs and AKT1 haplotypes were reported in US and Japanese samples. To evaluate the association between AKT1 and Meth-use disorder, we conducted a case-control study of Japanese samples (182 patients and 437 controls). A positive association between a SNP and haplotypes was found, and the 'signal' SNP was the same SNP found to be associated with US schizophrenia, but not with Japanese schizophrenia. Our results indicate that AKT1 may play a possible role in the development of Meth-use disorder. Further investigation of these associations, together with evidence from previous animal studies, may open the way to elucidation of the pathophysiology of this condition.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
AKT1Humanamphetamine abuse susceptibilityIAGP DNA:SNP:intron: (rs3730358)RGD 
Akt1Ratamphetamine abuse susceptibilityISOAKT1 (Homo sapiens)DNA:SNP:intron: (rs3730358)RGD 
Akt1Mouseamphetamine abuse susceptibilityISOAKT1 (Homo sapiens)DNA:SNP:intron: (rs3730358)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
AKT1HumanAddictive methamphetamine use susceptibilityIAGP DNA:SNP:intron: (rs3730358)RGD 
Objects Annotated

Genes (Rattus norvegicus)
Akt1  (AKT serine/threonine kinase 1)

Genes (Mus musculus)
Akt1  (thymoma viral proto-oncogene 1)

Genes (Homo sapiens)
AKT1  (AKT serine/threonine kinase 1)


Additional Information