Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:amyloid precursor protein catabolic process
go back to main search page
Accession:GO:0042987 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease.
Synonyms:exact_synonym: APP catabolic process;   APP catabolism;   amyloid precursor protein breakdown;   amyloid precursor protein catabolism;   amyloid precursor protein degradation


show annotations for term's descendants           Sort by:
amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg1 ATP binding cassette subfamily G member 1 involved_in ISO (PMID:17293612) RGD PMID:17293612 NCBI chr20:9,128,056...9,184,312 JBrowse link
G Adam10 ADAM metallopeptidase domain 10 involved_in ISO
IEA		 (PMID:28164773)
GO_REF:0000107		 RGD
Ensembl		 PMID:28164773 GO_REF:0000107 NCBI chr 8:80,226,862...80,358,728 JBrowse link
G Adam17 ADAM metallopeptidase domain 17 involved_in ISO
IEA		 (PMID:9774383)
GO_REF:0000107		 RGD
Ensembl		 PMID:9774383 GO_REF:0000107 NCBI chr 6:46,601,583...46,663,690 JBrowse link
G Adam19 ADAM metallopeptidase domain 19 involved_in ISO (PMID:17112471) RGD PMID:17112471 NCBI chr10:30,992,713...31,084,455 JBrowse link
G Adam9 ADAM metallopeptidase domain 9 involved_in ISO (PMID:12054541) RGD PMID:12054541 NCBI chr16:73,725,186...73,804,284 JBrowse link
G Aph1a aph-1 homolog A, gamma secretase subunit involved_in ISO UniProtKB:P05067|UniProtKB:P49768 (PMID:12297508), (PMID:12763021), (PMID:15274632), (PMID:27608597) RGD PMID:12297508 PMID:12763021 PMID:15274632 PMID:27608597 NCBI chr 2:186,123,023...186,130,886 JBrowse link
G Aph1b aph-1 homolog B, gamma secretase subunit involved_in ISO UniProtKB:P05067|UniProtKB:P49768 (PMID:12763021), (PMID:27608597) RGD PMID:12763021 PMID:27608597 NCBI chr 8:76,310,380...76,334,146 JBrowse link
G Bace1 beta-secretase 1 involved_in ISO UniProtKB:Q9BZC7 (PMID:20704561) RGD PMID:20704561 NCBI chr 8:55,038,842...55,061,138 JBrowse link
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in ISO (PMID:10924275) RGD PMID:10924275 NCBI chr 1:190,586,649...190,600,034 JBrowse link
G Dhcr24 24-dehydrocholesterol reductase acts_upstream_of_or_within ISO MGI:3027024 (PMID:16407971) RGD PMID:16407971 NCBI chr 5:126,573,366...126,599,940 JBrowse link
G Ncstn nicastrin involved_in ISO UniProtKB:P05067|UniProtKB:P49768 (PMID:12763021), (PMID:15274632), (PMID:27608597) RGD PMID:12763021 PMID:15274632 PMID:27608597 NCBI chr13:87,062,827...87,078,839 JBrowse link
G Psen1 presenilin 1 involved_in
acts_upstream_of_or_within		 ISO UniProtKB:P05067 (PMID:12297508), (PMID:12763021), (PMID:27608597)
MGI:2149116|MGI:2179062|MGI:2449304 (PMID:10206645), (PMID:11567612), (PMID:15452145)		 RGD PMID:10206645 PMID:11567612 PMID:12297508 PMID:12763021 PMID:15452145 More... NCBI chr 6:109,054,160...109,106,191 JBrowse link
G Psen2 presenilin 2 involved_in ISO (PMID:27608597) RGD PMID:27608597 NCBI chr13:94,499,451...94,528,419 JBrowse link
G Psenen presenilin enhancer gamma secretase subunit involved_in ISO UniProtKB:P05067|UniProtKB:P49768 (PMID:12660785), (PMID:12763021), (PMID:15274632) RGD PMID:12660785 PMID:12763021 PMID:15274632 NCBI chr 1:94,942,348...94,943,545 JBrowse link
amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO
IEA
ISS		 (PMID:26260791)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:26260791 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:10,342,092...10,362,094 JBrowse link
G Adam10 ADAM metallopeptidase domain 10 involved_in IMP PMID:17301176 SynGO-UCL PMID:17301176 RGD:12907557 NCBI chr 8:80,226,862...80,358,728 JBrowse link
G Aph1a aph-1 homolog A, gamma secretase subunit involved_in ISO UniProtKB:P05067|UniProtKB:P49768 (PMID:12297508), (PMID:12763021), (PMID:25043039), (PMID:26280335), (PMID:27608597) RGD PMID:12297508 PMID:12763021 PMID:25043039 PMID:26280335 PMID:27608597 NCBI chr 2:186,123,023...186,130,886 JBrowse link
G Aph1b aph-1 homolog B, gamma secretase subunit involved_in
acts_upstream_of_or_within		 ISO UniProtKB:P05067|UniProtKB:P49768 (PMID:12763021), (PMID:27608597)
MGI:1202717|MGI:1891700 (PMID:16371134)		 RGD PMID:12763021 PMID:16371134 PMID:27608597 NCBI chr 8:76,310,380...76,334,146 JBrowse link
G Apoa1 apolipoprotein A1 involved_in ISO (PMID:27992182) RGD PMID:27992182 NCBI chr 8:55,423,945...55,425,729 JBrowse link
G Bace1 beta-secretase 1 involved_in ISO (PMID:24352696) RGD PMID:24352696 NCBI chr 8:55,038,842...55,061,138 JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A involved_in ISO
IEA		 (PMID:25556849)
GO_REF:0000107		 RGD
Ensembl		 PMID:25556849 GO_REF:0000107 NCBI chr11:47,360,824...47,479,033 JBrowse link
G Ncstn nicastrin involved_in
acts_upstream_of_or_within		 ISS
ISO		 GO_REF:0000024
MGI:1202717|MGI:3522097 (PMID:16371134)
UniProtKB:P05067|UniProtKB:P49768 (PMID:12297508), (PMID:12763021), (PMID:25043039), (PMID:26280335), (PMID:27608597)		 UniProt
RGD		 PMID:12297508 PMID:12763021 PMID:16371134 PMID:25043039 PMID:26280335 More... GO_REF:0000024 NCBI chr13:87,062,827...87,078,839 JBrowse link
G Psen1 presenilin 1 involved_in
acts_upstream_of_or_within		 ISO
IBA
ISS		 UniProtKB:P05067 (PMID:12297508), (PMID:12763021), (PMID:26280335), (PMID:27608597)
MGI:1891700|MGI:2149116|MGI:3522097 (PMID:16371134), (PMID:20130175)
GO_REF:0000033
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:12297508 PMID:12763021 PMID:16371134 PMID:20130175 PMID:26280335 More... GO_REF:0000024 GO_REF:0000033 NCBI chr 6:109,054,160...109,106,191 JBrowse link
G Psen2 presenilin 2 involved_in ISO
IBA		 (PMID:27608597)
GO_REF:0000033		 RGD
GO_Central		 PMID:27608597 GO_REF:0000033 NCBI chr13:94,499,451...94,528,419 JBrowse link
G Psenen presenilin enhancer gamma secretase subunit involved_in ISS
ISO		 GO_REF:0000024
UniProtKB:P05067|UniProtKB:P49768 (PMID:12660785), (PMID:12763021), (PMID:25043039), (PMID:26280335)		 UniProt
RGD		 PMID:12660785 PMID:12763021 PMID:25043039 PMID:26280335 GO_REF:0000024 NCBI chr 1:94,942,348...94,943,545 JBrowse link
negative regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flot2 flotillin 2 involved_in ISO
IEA		 (PMID:24612608)
GO_REF:0000107		 RGD
Ensembl		 PMID:24612608 GO_REF:0000107 NCBI chr10:63,424,084...63,445,811 JBrowse link
G Mir15b microRNA 15b acts_upstream_of ISO (PMID:29961672) RGD PMID:29961672 NCBI chr 2:155,555,178...155,555,275 JBrowse link
G Mir29a microRNA 29a acts_upstream_of ISO (PMID:18434550) RGD PMID:18434550 NCBI chr 4:60,617,955...60,618,042 JBrowse link
G Mir29b1 microRNA 29b-1 acts_upstream_of ISO (PMID:18434550) RGD PMID:18434550 NCBI chr 4:60,618,334...60,618,414 JBrowse link
G Mir29b2 microRNA 29b-2 acts_upstream_of ISO (PMID:18434550) RGD PMID:18434550 NCBI chr13:109,098,831...109,098,911 JBrowse link
G Prnp prion protein involved_in ISO UniProtKB:P12023 (PMID:17573534) RGD PMID:17573534 NCBI chr 3:139,639,076...139,654,420 JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 involved_in ISO (PMID:24305806), (PMID:27853422) RGD PMID:24305806 PMID:27853422 NCBI chr18:1,387,360...1,509,218 JBrowse link
G Sorl1 sortilin related receptor 1 involved_in ISO (PMID:16407538), (PMID:17855360), (PMID:21989385)
(PMID:18362153)		 RGD PMID:16407538 PMID:17855360 PMID:18362153 PMID:21989385 NCBI chr 8:51,238,713...51,401,458 JBrowse link
negative regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISS
ISO		 GO_REF:0000024
(PMID:18429932), (PMID:23467355), (PMID:27030769)		 Alzheimers_University_of_Toronto
RGD		 PMID:18429932 PMID:23467355 PMID:27030769 GO_REF:0000024 NCBI chr 7:10,342,092...10,362,094 JBrowse link
G Apoe apolipoprotein E involved_in ISO
IEA		 (PMID:24154541)
(PMID:24259049)
GO_REF:0000107		 RGD
Ensembl		 PMID:24154541 PMID:24259049 GO_REF:0000107 NCBI chr 1:88,481,889...88,485,816 JBrowse link
G Bin1 bridging integrator 1 involved_in ISO
IEA		 (PMID:27179792)
GO_REF:0000107		 RGD
Ensembl		 PMID:27179792 GO_REF:0000107 NCBI chr18:24,282,840...24,341,461 JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in ISO UniProtKB:P05067 (PMID:20708605) RGD PMID:20708605 NCBI chr 1:126,123,425...126,249,181 JBrowse link
G Clu clusterin involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:12047389), (PMID:17412999)		 Alzheimers_University_of_Toronto
Ensembl
RGD		 PMID:12047389 PMID:17412999 GO_REF:0000024 GO_REF:0000107 NCBI chr15:44,336,619...44,375,861 JBrowse link
G Gga3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 involved_in ISO (PMID:17553422) RGD PMID:17553422 NCBI chr10:101,324,378...101,342,373 JBrowse link
G Hap1 huntingtin-associated protein 1 involved_in IMP PMID:22731248 UniProt PMID:22731248 RGD:10047200 NCBI chr10:85,778,267...85,786,553 JBrowse link
G Igf1 insulin-like growth factor 1 involved_in ISO
IEA		 RNAcentral:URS000034B6F5_9606 (PMID:27277332)
GO_REF:0000107		 RGD
Ensembl		 PMID:27277332 GO_REF:0000107 NCBI chr 7:24,169,608...24,249,446 JBrowse link
G Mir103a1 microRNA 103a-1 acts_upstream_of ISO (PMID:27343180) RGD PMID:27343180 NCBI chr10:20,748,474...20,748,559 JBrowse link
G Mir103a2 microRNA 103a-2 acts_upstream_of ISO (PMID:27343180) RGD PMID:27343180 NCBI chr 3:138,963,227...138,963,312 JBrowse link
G Mir153 microRNA 153 involved_in ISO (PMID:22733824) RGD PMID:22733824 NCBI chr 6:144,306,594...144,306,680 JBrowse link
G Mir15b microRNA 15b acts_upstream_of ISO (PMID:29961672) RGD PMID:29961672 NCBI chr 2:155,555,178...155,555,275 JBrowse link
G Mir16 microRNA 16 acts_upstream_of ISO (PMID:27343180) RGD PMID:27343180 NCBI chr 2:155,555,327...155,555,421 JBrowse link
G Mir186 microRNA 186 acts_upstream_of ISO (PMID:25100943) RGD PMID:25100943 NCBI chr 2:249,241,650...249,241,735 JBrowse link
G Mir24-2 microRNA 24-2 acts_upstream_of ISO (PMID:25100943) RGD PMID:25100943 NCBI chr19:40,859,455...40,859,562 JBrowse link
G Mir298 microRNA 298 acts_upstream_of ISO (PMID:31942037) RGD PMID:31942037 NCBI chr 3:183,470,522...183,470,603 JBrowse link
G Mir29a microRNA 29a acts_upstream_of ISO (PMID:18434550) RGD PMID:18434550 NCBI chr 4:60,617,955...60,618,042 JBrowse link
G Mir29b1 microRNA 29b-1 acts_upstream_of ISO (PMID:18434550) RGD PMID:18434550 NCBI chr 4:60,618,334...60,618,414 JBrowse link
G Mir29b2 microRNA 29b-2 acts_upstream_of ISO (PMID:18434550) RGD PMID:18434550 NCBI chr13:109,098,831...109,098,911 JBrowse link
G Mir339 microRNA 339 acts_upstream_of ISO (PMID:24352696) RGD PMID:24352696 NCBI chr12:20,391,395...20,391,490 JBrowse link
G Mir361 microRNA 361 involved_in ISO (PMID:31601077) RGD PMID:31601077 NCBI chr  X:82,438,463...82,438,532 JBrowse link
G Mir455 microRNA 455 acts_upstream_of ISO (PMID:25100943), (PMID:31181293) RGD PMID:25100943 PMID:31181293 NCBI chr 5:81,704,834...81,704,911 JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
UniProtKB:P05067-4 (PMID:26094765)		 Ensembl
RGD		 PMID:26094765 GO_REF:0000107 NCBI chr17:5,560,558...5,875,899 JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 involved_in ISO (PMID:25576397)
(PMID:16554819)		 RGD PMID:16554819 PMID:25576397 NCBI chr 8:27,465,538...27,477,016 JBrowse link
G Prnp prion protein involved_in ISO UniProtKB:P12023 (PMID:17573534) RGD PMID:17573534 NCBI chr 3:139,639,076...139,654,420 JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 involved_in ISO
IEA		 (PMID:24305806), (PMID:27853422)
GO_REF:0000107		 RGD
Ensembl		 PMID:24305806 PMID:27853422 GO_REF:0000107 NCBI chr18:1,387,360...1,509,218 JBrowse link
G Rtn1 reticulon 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:15286784)		 UniProt
Ensembl
RGD		 PMID:15286784 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:96,499,137...96,719,340 JBrowse link
G Rtn2 reticulon 2 involved_in ISO
ISS		 (PMID:15286784)
GO_REF:0000024		 RGD
UniProt		 PMID:15286784 GO_REF:0000024 NCBI chr 1:88,063,124...88,076,082 JBrowse link
G Rtn3 reticulon 3 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:15286784)		 UniProt
Ensembl
RGD		 PMID:15286784 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:214,041,838...214,098,644 JBrowse link
G Rtn4 reticulon 4 involved_in ISO
IEA
ISS		 (PMID:15286784)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:15286784 GO_REF:0000024 GO_REF:0000107 NCBI chr14:107,651,001...107,698,610 JBrowse link
G Sorl1 sortilin related receptor 1 involved_in ISO (PMID:18362153), (PMID:19036982)
(PMID:16174740), (PMID:16407538), (PMID:17855360), (PMID:21989385), (PMID:22621900), (PMID:24001769), (PMID:24523320)		 RGD PMID:16174740 PMID:16407538 PMID:17855360 PMID:18362153 PMID:19036982 More... NCBI chr 8:51,238,713...51,401,458 JBrowse link
G Spon1 spondin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:16227578)		 Ensembl
RGD		 PMID:16227578 GO_REF:0000107 NCBI chr 1:177,363,526...177,662,689 JBrowse link
negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bin1 bridging integrator 1 involved_in ISO (PMID:27179792) RGD PMID:27179792 NCBI chr18:24,282,840...24,341,461 JBrowse link
G Tmed10 transmembrane p24 trafficking protein 10 acts_upstream_of_or_within ISO (PMID:16641999) RGD PMID:16641999 NCBI chr 6:110,722,887...110,757,743 JBrowse link
positive regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of ISO UniProtKB:P56818 (PMID:20704561), (PMID:22086926) RGD PMID:20704561 PMID:22086926 NCBI chr 3:28,642,660...28,662,689 JBrowse link
G Ager advanced glycosylation end product-specific receptor involved_in ISO UniProtKB:P05067-PRO_0000000093 (PMID:22406537) RGD PMID:22406537 NCBI chr20:4,152,758...4,155,956 JBrowse link
G App amyloid beta precursor protein involved_in ISO UniProtKB:Q15109 (PMID:22406537) RGD PMID:22406537 NCBI chr11:37,506,207...37,724,351 JBrowse link
G Efna1 ephrin A1 involved_in ISO UniProtKB:P54764 (PMID:24217950) RGD PMID:24217950 NCBI chr 2:176,979,434...176,988,675 JBrowse link
G Efna3 ephrin A3 involved_in ISO UniProtKB:P54764 (PMID:24217950) RGD PMID:24217950 NCBI chr 2:177,026,928...177,035,838 JBrowse link
G Epha4 Eph receptor A4 involved_in ISO UniProtKB:P20827|UniProtKB:P52797 (PMID:24217950) RGD PMID:24217950 NCBI chr 9:86,263,982...86,406,744 JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in ISO (PMID:24217950) RGD PMID:24217950 NCBI chr 5:21,437,127...21,553,097 JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in ISS
ISO		 GO_REF:0000024
(PMID:22539346)		 Alzheimers_University_of_Toronto
RGD		 PMID:22539346 GO_REF:0000024 NCBI chr 1:153,468,982...153,550,086 JBrowse link
G Ranbp9 RAN binding protein 9 acts_upstream_of IGI PMID:24592211 ARUK-UCL PMID:24592211 RGD:38501074 NCBI chr17:21,426,717...21,508,964 JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 involved_in ISO (PMID:24305806) RGD PMID:24305806 NCBI chr 6:45,407,823...45,502,773 JBrowse link
G Spon1 spondin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:16227578)		 Ensembl
RGD		 PMID:16227578 GO_REF:0000107 NCBI chr 1:177,363,526...177,662,689 JBrowse link
positive regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of
involved_in		 ISO
IEA
IMP		 (PMID:22086926)
GO_REF:0000107		 RGD
Ensembl		 PMID:22086926 PMID:22086926 GO_REF:0000107, RGD:14697726 NCBI chr 3:28,642,660...28,662,689 JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 involved_in ISO (PMID:17293612) RGD PMID:17293612 NCBI chr20:9,128,056...9,184,312 JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:24154541), (PMID:24259049) RGD PMID:24154541 PMID:24259049 NCBI chr 1:88,481,889...88,485,816 JBrowse link
G Casp3 caspase 3 involved_in IDA
ISO		 PMID:17553422
(PMID:17553422)		 RGD PMID:17553422 PMID:17553422 RGD:13825190 NCBI chr16:52,395,539...52,413,794 JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in IEA
ISO		 GO_REF:0000107
UniProtKB:P05067 (PMID:20164328)		 Ensembl
RGD		 PMID:20164328 GO_REF:0000107 NCBI chr 1:126,123,425...126,249,181 JBrowse link
G Clu clusterin involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:12145324)
GO_REF:0000024		 Ensembl
RGD
Alzheimers_University_of_Toronto		 PMID:12145324 GO_REF:0000024 GO_REF:0000107 NCBI chr15:44,336,619...44,375,861 JBrowse link
G Csnk1e casein kinase 1, epsilon IDA RGD PMID:17360493 RGD:10395238 NCBI chr 7:112,863,726...112,887,338 JBrowse link
G Efna1 ephrin A1 involved_in ISO
IEA		 (PMID:24217950)
GO_REF:0000107		 RGD
Ensembl		 PMID:24217950 GO_REF:0000107 NCBI chr 2:176,979,434...176,988,675 JBrowse link
G Epha4 Eph receptor A4 involved_in ISO UniProtKB:P20827 (PMID:24217950) RGD PMID:24217950 NCBI chr 9:86,263,982...86,406,744 JBrowse link
G Gsap gamma-secretase activating protein involved_in ISO
IBA		 (PMID:20811458)
GO_REF:0000033		 RGD
GO_Central		 PMID:20811458 GO_REF:0000033 NCBI chr 4:14,705,237...14,800,057 JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in ISO
IEA		 UniProtKB:P49841 (PMID:12761548)
GO_REF:0000107		 RGD
Ensembl		 PMID:12761548 GO_REF:0000107 NCBI chr 1:89,943,669...89,953,514 JBrowse link
G Ifng interferon gamma involved_in ISO UniProtKB:P05067|UniProtKB:P10636|UniProtKB:P49768 (PMID:19808651)
UniProtKB:P05067|UniProtKB:P15261 (PMID:17255335)		 RGD PMID:17255335 PMID:19808651 NCBI chr 7:55,789,180...55,793,216 JBrowse link
G Ifngr1 interferon gamma receptor 1 involved_in ISO UniProtKB:P01579|UniProtKB:P05067 (PMID:17255335) RGD PMID:17255335 NCBI chr 1:16,152,811...16,171,439 JBrowse link
G Lrrtm3 leucine rich repeat transmembrane neuronal 3 acts_upstream_of_or_within ISO (PMID:17098871) RGD PMID:17098871 NCBI chr20:24,514,304...24,688,322 JBrowse link
G Mir206 microRNA 206 involved_in ISO (PMID:27277332) RGD PMID:27277332 NCBI chr 9:30,590,697...30,590,780 JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in ISO
ISS
IEA		 (PMID:24577224)
(PMID:22539346), (PMID:24577224)
GO_REF:0000024
GO_REF:0000107		 RGD
Alzheimers_University_of_Toronto
Ensembl		 PMID:22539346 PMID:24577224 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:153,468,982...153,550,086 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit acts_upstream_of ISO (PMID:21329555) RGD PMID:21329555 NCBI chr 1:212,354,336...212,364,815 JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 involved_in ISO
IEA		 (PMID:24305806)
GO_REF:0000107		 RGD
Ensembl		 PMID:24305806 GO_REF:0000107 NCBI chr 6:45,407,823...45,502,773 JBrowse link
G Slc2a13 solute carrier family 2 member 13 involved_in ISO UniProtKB:P05067-4 (PMID:26094765) RGD PMID:26094765 NCBI chr 7:124,278,881...124,606,146 JBrowse link
G Sp1 Sp1 transcription factor acts_upstream_of ISO (PMID:14701757) RGD PMID:14701757 NCBI chr 7:135,419,864...135,450,513 JBrowse link
G Tnf tumor necrosis factor involved_in ISO (PMID:17255335) RGD PMID:17255335 NCBI chr20:3,626,685...3,629,303 JBrowse link
regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO
IEA
ISS		 (PMID:26260791)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:26260791 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:10,342,092...10,362,094 JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:28164773) RGD PMID:28164773 NCBI chr 1:88,481,889...88,485,816 JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in ISO UniProtKB:P05067 (PMID:20708605) RGD PMID:20708605 NCBI chr 1:126,123,425...126,249,181 JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A involved_in ISO UniProtKB:P05067 (PMID:24499793) RGD PMID:24499793 NCBI chr 3:160,500,748...160,520,492 JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in ISS
ISO		 GO_REF:0000024
(PMID:24577224)		 Alzheimers_University_of_Toronto
RGD		 PMID:24577224 GO_REF:0000024 NCBI chr 1:153,468,982...153,550,086 JBrowse link
G Unc13a unc-13 homolog A involved_in ISO (PMID:23070049) RGD PMID:23070049 NCBI chr16:18,367,891...18,415,808 JBrowse link
regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Picalm phosphatidylinositol binding clathrin assembly protein NOT|involved_in ISO UniProtKB:P05067-PRO_0000000092 (PMID:26005850) RGD PMID:26005850 NCBI chr 1:153,468,982...153,550,086 JBrowse link
G Tmed10 transmembrane p24 trafficking protein 10 involved_in ISO
IEA
ISS		 (PMID:16641999)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:16641999 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:110,722,887...110,757,743 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20533
    cellular process 19522
      metabolic process 12156
        primary metabolic process 10741
          protein metabolic process 5231
            amyloid precursor protein metabolic process 94
              amyloid precursor protein catabolic process 74
                amyloid-beta formation + 61
                negative regulation of amyloid precursor protein catabolic process + 34
                positive regulation of amyloid precursor protein catabolic process + 27
                regulation of amyloid precursor protein catabolic process + 59
paths to the root