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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of amyloid precursor protein catabolic process
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Accession:GO:1902992 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of amyloid precursor protein catabolic process.
Synonyms:exact_synonym: down regulation of APP catabolic process;   down regulation of APP catabolism;   down regulation of amyloid precursor protein breakdown;   down regulation of amyloid precursor protein catabolic process;   down regulation of amyloid precursor protein catabolism;   down regulation of amyloid precursor protein degradation;   downregulation of APP catabolic process;   downregulation of APP catabolism;   downregulation of amyloid precursor protein breakdown;   downregulation of amyloid precursor protein catabolic process;   downregulation of amyloid precursor protein catabolism;   downregulation of amyloid precursor protein degradation;   negative regulation of APP catabolic process;   negative regulation of APP catabolism;   negative regulation of amyloid precursor protein breakdown;   negative regulation of amyloid precursor protein catabolism;   negative regulation of amyloid precursor protein degradation
 narrow_synonym: inhibition of APP catabolic process;   inhibition of APP catabolism;   inhibition of amyloid precursor protein breakdown;   inhibition of amyloid precursor protein catabolic process;   inhibition of amyloid precursor protein catabolism;   inhibition of amyloid precursor protein degradation


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negative regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flot2 flotillin 2 involved_in ISO (PMID:24612608) RGD PMID:24612608 NCBI chr10:62,926,047...62,947,759
Ensembl chr10:62,920,665...62,947,756 		JBrowse link
G Mir15b microRNA 15b acts_upstream_of ISO (PMID:29961672) RGD PMID:29961672 NCBI chr 2:153,245,200...153,245,297
Ensembl chr 2:153,245,200...153,245,297 		JBrowse link
G Mir29a microRNA 29a acts_upstream_of ISO (PMID:18434550) RGD PMID:18434550 NCBI chr 4:59,650,608...59,650,695 JBrowse link
G Mir29b1 microRNA 29b-1 acts_upstream_of ISO (PMID:18434550) RGD PMID:18434550 NCBI chr 4:59,650,987...59,651,067
Ensembl chr 4:59,650,986...59,651,067 		JBrowse link
G Mir29b2 microRNA 29b-2 acts_upstream_of ISO (PMID:18434550) RGD PMID:18434550 NCBI chr13:106,570,371...106,570,451
Ensembl chr13:106,570,367...106,570,456 		JBrowse link
G Prnp prion protein involved_in ISO UniProtKB:P12023 (MGI:3714552|PMID:17573534) RGD PMID:17573534 MGI:3714552 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 involved_in ISO (PMID:24305806), (PMID:27853422) RGD PMID:24305806 PMID:27853422 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571 		JBrowse link
negative regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5487687|PMID:23467355), (MGI:5553242|PMID:18429932), (MGI:5774886|PMID:27030769)		 Alzheimers_University_of_Toronto
RGD		 PMID:18429932 PMID:23467355 PMID:27030769 GO_REF:0000024 MGI:5487687 MGI:5553242 MGI:5774886 NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425 		JBrowse link
G Apoe apolipoprotein E involved_in IEA
ISO		 GO_REF:0000107
(PMID:24154541)
(PMID:24259049)		 Ensembl
RGD		 PMID:24154541 PMID:24259049 GO_REF:0000107 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Bin1 bridging integrator 1 involved_in ISO
IEA		 (PMID:27179792)
(MGI:5811968|PMID:27179792)
GO_REF:0000107		 RGD
Ensembl		 PMID:27179792 GO_REF:0000107 MGI:5811968 NCBI chr18:24,009,731...24,067,267
Ensembl chr18:24,009,653...24,067,263 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in ISO UniProtKB:P05067 (PMID:20708605) RGD PMID:20708605 NCBI chr 1:116,715,286...116,837,223
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
G Clu clusterin involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:12047389), (PMID:17412999)
GO_REF:0000024		 Ensembl
RGD
Alzheimers_University_of_Toronto		 PMID:12047389 PMID:17412999 GO_REF:0000024 GO_REF:0000107 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Gga3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 involved_in ISO (PMID:17553422) RGD PMID:17553422 NCBI chr10:100,825,426...100,844,462
Ensembl chr10:100,825,426...100,844,462 		JBrowse link
G Hap1 huntingtin-associated protein 1 involved_in IMP PMID:22731248 UniProt PMID:22731248 RGD:10047200 NCBI chr10:85,277,890...85,286,126
Ensembl chr10:85,277,890...85,286,126 		JBrowse link
G Igf1 insulin-like growth factor 1 involved_in ISO
IEA		 RNAcentral:URS000034B6F5_9606 (PMID:27277332)
GO_REF:0000107		 RGD
Ensembl		 PMID:27277332 GO_REF:0000107 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Mir153 microRNA 153 involved_in ISO (PMID:22733824) RGD PMID:22733824 NCBI chr 6:138,163,595...138,163,681
Ensembl chr 6:138,163,595...138,163,681 		JBrowse link
G Mir15b microRNA 15b acts_upstream_of ISO (PMID:29961672) RGD PMID:29961672 NCBI chr 2:153,245,200...153,245,297
Ensembl chr 2:153,245,200...153,245,297 		JBrowse link
G Mir186 microRNA 186 acts_upstream_of ISO (PMID:25100943) RGD PMID:25100943 NCBI chr 2:246,582,806...246,582,891
Ensembl chr 2:246,582,806...246,582,891 		JBrowse link
G Mir24-2 microRNA 24-2 acts_upstream_of ISO (PMID:25100943) RGD PMID:25100943 NCBI chr19:23,954,683...23,954,790
Ensembl chr19:23,954,683...23,954,790 		JBrowse link
G Mir298 microRNA 298 acts_upstream_of ISO (PMID:31942037) RGD PMID:31942037 NCBI chr 3:163,052,291...163,052,372
Ensembl chr 3:163,052,291...163,052,372 		JBrowse link
G Mir29a microRNA 29a acts_upstream_of ISO (PMID:18434550) RGD PMID:18434550 NCBI chr 4:59,650,608...59,650,695 JBrowse link
G Mir29b1 microRNA 29b-1 acts_upstream_of ISO (PMID:18434550) RGD PMID:18434550 NCBI chr 4:59,650,987...59,651,067
Ensembl chr 4:59,650,986...59,651,067 		JBrowse link
G Mir29b2 microRNA 29b-2 acts_upstream_of ISO (PMID:18434550) RGD PMID:18434550 NCBI chr13:106,570,371...106,570,451
Ensembl chr13:106,570,367...106,570,456 		JBrowse link
G Mir339 microRNA 339 acts_upstream_of ISO (PMID:24352696) RGD PMID:24352696 NCBI chr12:15,277,546...15,277,641
Ensembl chr12:15,277,546...15,277,641 		JBrowse link
G Mir361 microRNA 361 involved_in ISO (PMID:31601077) RGD PMID:31601077 NCBI chr  X:78,246,206...78,246,275
Ensembl chr  X:78,246,206...78,246,275 		JBrowse link
G Mir455 microRNA 455 acts_upstream_of ISO (PMID:25100943), (PMID:31181293) RGD PMID:25100943 PMID:31181293 NCBI chr 5:76,689,313...76,689,390
Ensembl chr 5:76,689,313...76,689,390 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
UniProtKB:P05067-4 (PMID:26094765)		 Ensembl
RGD		 PMID:26094765 GO_REF:0000107 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Olfm1 olfactomedin 1 acts_upstream_of_or_within ISO (MGI:5444053|PMID:22992957) RGD PMID:22992957 MGI:5444053 NCBI chr 3:11,520,522...11,558,240
Ensembl chr 3:11,520,729...11,558,239 		JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 involved_in ISO (PMID:25576397)
(MGI:3620333|PMID:16554819)		 RGD PMID:16554819 PMID:25576397 MGI:3620333 NCBI chr 8:19,189,408...19,200,785
Ensembl chr 8:19,189,373...19,200,785 		JBrowse link
G Prnp prion protein involved_in ISO UniProtKB:P12023 (MGI:3714552|PMID:17573534) RGD PMID:17573534 MGI:3714552 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:24305806), (PMID:27853422)		 Ensembl
RGD		 PMID:24305806 PMID:27853422 GO_REF:0000107 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571 		JBrowse link
G Rtn1 reticulon 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:15286784)		 UniProt
RGD		 PMID:15286784 GO_REF:0000024 NCBI chr 6:90,763,212...90,983,436
Ensembl chr 6:90,763,216...90,983,436 		JBrowse link
G Rtn2 reticulon 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:15286784)		 UniProt
RGD		 PMID:15286784 GO_REF:0000024 NCBI chr 1:78,935,056...78,948,069
Ensembl chr 1:78,935,104...78,948,069 		JBrowse link
G Rtn3 reticulon 3 involved_in ISS
ISO		 GO_REF:0000024
(PMID:15286784)		 UniProt
RGD		 PMID:15286784 GO_REF:0000024 NCBI chr 1:204,612,675...204,669,212
Ensembl chr 1:204,612,675...204,669,275 		JBrowse link
G Rtn4 reticulon 4 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:15286784)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:15286784 GO_REF:0000024 GO_REF:0000107 NCBI chr14:103,450,074...103,497,687
Ensembl chr14:103,449,930...103,497,686 		JBrowse link
G Sorl1 sortilin related receptor 1 involved_in ISO (MGI:3801250|PMID:18362153), (MGI:3821635|PMID:19036982)
(PMID:16407538), (PMID:17855360), (PMID:21989385), (PMID:22621900), (PMID:24001769), (PMID:24523320)		 RGD PMID:16407538 PMID:17855360 PMID:18362153 PMID:19036982 PMID:21989385 More... MGI:3801250 MGI:3821635 NCBI chr 8:42,341,704...42,504,435
Ensembl chr 8:42,341,704...42,504,513 		JBrowse link
G Spon1 spondin 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3607023|PMID:16227578)
GO_REF:0000107		 RGD
Ensembl		 PMID:16227578 GO_REF:0000107 MGI:3607023 NCBI chr 1:167,929,049...168,228,239
Ensembl chr 1:167,928,972...168,228,226 		JBrowse link
negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bin1 bridging integrator 1 involved_in ISO
IEA		 (MGI:5811968|PMID:27179792)
(PMID:27179792)
GO_REF:0000107		 RGD
Ensembl		 PMID:27179792 GO_REF:0000107 MGI:5811968 NCBI chr18:24,009,731...24,067,267
Ensembl chr18:24,009,653...24,067,263 		JBrowse link
G Sorl1 sortilin related receptor 1 involved_in ISO (MGI:3801250|PMID:18362153)
(PMID:16407538), (PMID:17855360), (PMID:21989385)		 RGD PMID:16407538 PMID:17855360 PMID:18362153 PMID:21989385 MGI:3801250 NCBI chr 8:42,341,704...42,504,435
Ensembl chr 8:42,341,704...42,504,513 		JBrowse link
G Tmed10 transmembrane p24 trafficking protein 10 acts_upstream_of_or_within ISO (MGI:3623864|PMID:16641999) RGD PMID:16641999 MGI:3623864 NCBI chr 6:104,991,843...105,026,705
Ensembl chr 6:104,991,838...105,026,753 		JBrowse link
negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:5432454|PMID:22539346)		 Alzheimers_University_of_Toronto
Ensembl
RGD		 PMID:22539346 GO_REF:0000024 GO_REF:0000107 MGI:5432454 NCBI chr 1:144,056,415...144,138,045
Ensembl chr 1:144,056,721...144,137,557 		JBrowse link
G Sorl1 sortilin related receptor 1 involved_in ISO (MGI:3801250|PMID:18362153)
(PMID:17855360), (PMID:21989385)		 RGD PMID:17855360 PMID:18362153 PMID:21989385 MGI:3801250 NCBI chr 8:42,341,704...42,504,435
Ensembl chr 8:42,341,704...42,504,513 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19746
    metabolic process 12044
      negative regulation of metabolic process 3296
        negative regulation of nitrogen compound metabolic process 2525
          negative regulation of protein metabolic process 1162
            negative regulation of amyloid precursor protein catabolic process 33
              negative regulation of amyloid-beta formation 30
              negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process 3
              negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process 2
Path 2
Term Annotations click to browse term
  biological_process 19746
    metabolic process 12044
      organic substance metabolic process 11597
        macromolecule metabolic process 9959
          protein metabolic process 5951
            amyloid precursor protein metabolic process 93
              amyloid precursor protein catabolic process 71
                regulation of amyloid precursor protein catabolic process 57
                  negative regulation of amyloid precursor protein catabolic process 33
                    negative regulation of amyloid-beta formation 30
                    negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process 3
                    negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process 2
paths to the root