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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of amyloid precursor protein catabolic process
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Accession:GO:1902992 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of amyloid precursor protein catabolic process.
Synonyms:exact_synonym: down regulation of APP catabolic process;   down regulation of APP catabolism;   down regulation of amyloid precursor protein breakdown;   down regulation of amyloid precursor protein catabolic process;   down regulation of amyloid precursor protein catabolism;   down regulation of amyloid precursor protein degradation;   downregulation of APP catabolic process;   downregulation of APP catabolism;   downregulation of amyloid precursor protein breakdown;   downregulation of amyloid precursor protein catabolic process;   downregulation of amyloid precursor protein catabolism;   downregulation of amyloid precursor protein degradation;   negative regulation of APP catabolic process;   negative regulation of APP catabolism;   negative regulation of amyloid precursor protein breakdown;   negative regulation of amyloid precursor protein catabolism;   negative regulation of amyloid precursor protein degradation
 narrow_synonym: inhibition of APP catabolic process;   inhibition of APP catabolism;   inhibition of amyloid precursor protein breakdown;   inhibition of amyloid precursor protein catabolic process;   inhibition of amyloid precursor protein catabolism;   inhibition of amyloid precursor protein degradation


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negative regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flot2 flotillin 2 involved_in ISO (PMID:24612608) RGD PMID:24612608 NCBI chr10:65,304,901...65,329,332
Ensembl chr10:65,304,902...65,329,312
JBrowse link
G Prnp prion protein involved_in ISO UniProtKB:P12023 (MGI:3714552|PMID:17573534) RGD PMID:17573534 MGI:3714552 NCBI chr 3:124,515,917...124,531,320
Ensembl chr 3:124,515,978...124,531,316
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 involved_in ISO (PMID:24305806), (PMID:27853422) RGD PMID:24305806 PMID:27853422 NCBI chr18:1,273,490...1,390,790
Ensembl chr18:1,273,453...1,390,190
JBrowse link
negative regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISS
ISO
GO_REF:0000024
(MGI:5487687|PMID:23467355), (MGI:5553242|PMID:18429932), (MGI:5774886|PMID:27030769)
Alzheimers_University_of_Toronto
RGD
PMID:18429932 PMID:23467355 PMID:27030769 GO_REF:0000024 MGI:5487687 MGI:5553242 MGI:5774886 NCBI chr 7:12,742,433...12,762,423
Ensembl chr 7:12,742,433...12,762,341
JBrowse link
G Apoe apolipoprotein E involved_in ISO
IEA
(PMID:24259049)
GO_REF:0000107
(PMID:24154541)
RGD
Ensembl
PMID:24154541 PMID:24259049 GO_REF:0000107 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Bin1 bridging integrator 1 involved_in ISO
IEA
(PMID:27179792)
(MGI:5811968|PMID:27179792)
GO_REF:0000107
RGD
Ensembl
PMID:27179792 GO_REF:0000107 MGI:5811968 NCBI chr18:25,163,575...25,222,139
Ensembl chr18:25,163,561...25,222,135
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in ISO UniProtKB:P05067 (PMID:20708605) RGD PMID:20708605 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
JBrowse link
G Clu clusterin involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:12047389), (PMID:17412999)
Alzheimers_University_of_Toronto
Ensembl
RGD
PMID:12047389 PMID:17412999 GO_REF:0000024 GO_REF:0000107 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Gga3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 involved_in ISO (PMID:17553422) RGD PMID:17553422 NCBI chr10:104,137,655...104,156,576
Ensembl chr10:104,137,655...104,156,576
JBrowse link
G Hap1 huntingtin-associated protein 1 involved_in IMP PMID:22731248 UniProt PMID:22731248 RGD:10047200 NCBI chr10:88,257,975...88,266,210
Ensembl chr10:88,257,976...88,266,210
JBrowse link
G Igf1 insulin-like growth factor 1 involved_in ISO
IEA
RNAcentral:URS000034B6F5_9606 (PMID:27277332)
GO_REF:0000107
RGD
Ensembl
PMID:27277332 GO_REF:0000107 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
UniProtKB:P05067-4 (PMID:26094765)
Ensembl
RGD
PMID:26094765 GO_REF:0000107 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
JBrowse link
G Olfm1 olfactomedin 1 acts_upstream_of_or_within ISO (MGI:5444053|PMID:22992957) RGD PMID:22992957 MGI:5444053 NCBI chr 3:6,761,031...6,798,739
Ensembl chr 3:6,773,813...6,798,737
JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 involved_in ISO (PMID:25576397)
(MGI:3620333|PMID:16554819)
RGD PMID:16554819 PMID:25576397 MGI:3620333 NCBI chr 8:21,669,236...21,680,615
Ensembl chr 8:21,669,236...21,680,615
JBrowse link
G Prnp prion protein involved_in ISO UniProtKB:P12023 (MGI:3714552|PMID:17573534) RGD PMID:17573534 MGI:3714552 NCBI chr 3:124,515,917...124,531,320
Ensembl chr 3:124,515,978...124,531,316
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 involved_in ISO
IEA
(PMID:24305806), (PMID:27853422)
GO_REF:0000107
RGD
Ensembl
PMID:24305806 PMID:27853422 GO_REF:0000107 NCBI chr18:1,273,490...1,390,790
Ensembl chr18:1,273,453...1,390,190
JBrowse link
G Rtn1 reticulon 1 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:15286784)
UniProt
Ensembl
RGD
PMID:15286784 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:94,951,016...95,177,477
Ensembl chr 6:94,951,020...95,061,174
JBrowse link
G Rtn2 reticulon 2 involved_in ISO
ISS
(PMID:15286784)
GO_REF:0000024
RGD
UniProt
PMID:15286784 GO_REF:0000024 NCBI chr 1:80,195,594...80,208,449
Ensembl chr 1:80,195,532...80,208,448
JBrowse link
G Rtn3 reticulon 3 involved_in ISS
ISO
GO_REF:0000024
(PMID:15286784)
UniProt
RGD
PMID:15286784 GO_REF:0000024 NCBI chr 1:222,677,359...222,734,307
Ensembl chr 1:222,677,365...222,734,241
JBrowse link
G Rtn4 reticulon 4 involved_in ISO
IEA
ISS
(PMID:15286784)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:15286784 GO_REF:0000024 GO_REF:0000107 NCBI chr14:114,126,931...114,174,459
Ensembl chr14:114,126,943...114,174,458
JBrowse link
G Sorl1 sortilin related receptor 1 involved_in ISO (PMID:16407538), (PMID:17855360), (PMID:21989385), (PMID:22621900), (PMID:24001769), (PMID:24523320)
(MGI:3801250|PMID:18362153), (MGI:3821635|PMID:19036982)
RGD PMID:16407538 PMID:17855360 PMID:18362153 PMID:19036982 PMID:21989385 PMID:22621900 PMID:24001769 PMID:24523320 MGI:3801250 MGI:3821635 NCBI chr 8:46,228,077...46,287,171 JBrowse link
G Spon1 spondin 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3607023|PMID:16227578)
Ensembl
RGD
PMID:16227578 GO_REF:0000107 MGI:3607023 NCBI chr 1:178,568,777...178,935,715
Ensembl chr 1:178,636,544...178,935,051
JBrowse link
negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bin1 bridging integrator 1 involved_in IEA
ISO
GO_REF:0000107
(MGI:5811968|PMID:27179792)
(PMID:27179792)
Ensembl
RGD
PMID:27179792 GO_REF:0000107 MGI:5811968 NCBI chr18:25,163,575...25,222,139
Ensembl chr18:25,163,561...25,222,135
JBrowse link
G Sorl1 sortilin related receptor 1 involved_in ISO (PMID:16407538), (PMID:17855360), (PMID:21989385)
(MGI:3801250|PMID:18362153)
RGD PMID:16407538 PMID:17855360 PMID:18362153 PMID:21989385 MGI:3801250 NCBI chr 8:46,228,077...46,287,171 JBrowse link
G Tmed10 transmembrane p24 trafficking protein 10 acts_upstream_of_or_within ISO (MGI:3623864|PMID:16641999) RGD PMID:16641999 MGI:3623864 NCBI chr 6:109,169,739...109,205,004
Ensembl chr 6:109,169,741...109,205,004
JBrowse link
negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:5432454|PMID:22539346)
GO_REF:0000024
Ensembl
RGD
Alzheimers_University_of_Toronto
PMID:22539346 GO_REF:0000024 GO_REF:0000107 MGI:5432454 NCBI chr 1:154,377,229...154,458,966
Ensembl chr 1:154,377,247...154,458,425
JBrowse link
G Sorl1 sortilin related receptor 1 involved_in ISO (PMID:17855360), (PMID:21989385)
(MGI:3801250|PMID:18362153)
RGD PMID:17855360 PMID:18362153 PMID:21989385 MGI:3801250 NCBI chr 8:46,228,077...46,287,171 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19491
    metabolic process 11797
      negative regulation of metabolic process 3188
        negative regulation of nitrogen compound metabolic process 2501
          negative regulation of protein metabolic process 1119
            negative regulation of amyloid precursor protein catabolic process 22
              negative regulation of amyloid-beta formation 19
              negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process 3
              negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process 2
Path 2
Term Annotations click to browse term
  biological_process 19491
    metabolic process 11797
      organic substance metabolic process 11337
        macromolecule metabolic process 9793
          protein metabolic process 5893
            amyloid precursor protein metabolic process 74
              amyloid precursor protein catabolic process 59
                regulation of amyloid precursor protein catabolic process 45
                  negative regulation of amyloid precursor protein catabolic process 22
                    negative regulation of amyloid-beta formation 19
                    negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process 3
                    negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process 2
paths to the root